Citoesqueleto matriz excl 429

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The Cytoskeleton Figure 3.5
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Transcript of Citoesqueleto matriz excl 429

Slide 1

The CytoskeletonFigure 3.5

Figure 3.1

The Diversity of Cells

MreBactin likeFtsZtubulin likeCrescentinintermediate filament likeFtsZtubulin likein mitochondriaschloroplasts

Fig. 4-22b, p. 98

(b) Fluorescent LM showing microtubules in green. Amicrotubule-organizing center (pink dot) is visible besideor over most of the cell nuclei (blue).50 m

12Figure 4.22: Organization of microtubules.

MT axonmicosMT citoplsmicos

Acetilaciones de las tubulinas estabilizan los MT

ColchicineNocadozole

Vinblastine Vincristine

TaxolPaclitaxel

Centrioles

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Centrioles

Fig. 4-24b, p. 99(b) Note the 9 x 3 arrangement of microtubules.The centriole on the right has been cut transversely.

26Figure 4.24: Centrioles.

Centrioles and CiliaFigure 3.6

+-

Tau en las neuritas y axones

Neurofibrillary tangles(tauopathies)

Centrioles and CiliaFigure 3.6

Cilia

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Fig. 4-26b, p. 101

(b) Many bundles of microfilaments (green) are evident in thisfluorescent LM of fibroblasts, cells found in connective tissue.100 m

Microfilaments

43Figure 4.26: Microfilaments.

Citochalasin

Phaloidin

Fiber ShorteningAs sarcomeres shorten, muscle pulls together, producing tension

Figure 1013

Skeletal Muscle Innervation

Figure 1010a, b (Navigator)

Figure 103

A Thick FilamentFigure 107c

Figure 1011

Intermediate Filaments

90

CytokeratinVimentin (mesenchymal)

NF-H-pind (green) and Glial Fibrillary Acidic Protein (GFAP) (red)

Progeria

Cell JunctionsAnchoring junctionsHemidesmosomes- between cells in sheets of tissue Desmosomes- spot-weld animal cells togetherAdhering junctions- cement cells together formed by cadherins

103

Superfamilia de immunoglobulinas

N-CAM y L1-CAMRetardacin y defectos en cuerpo calloso

Clulas cancerosas bajan las cantidades de cadherinas.

DesmosomesCell recognition

Fibroblasts

Tight Junctions

112

Attachment to Basal LaminaHemidesmosomesFigure 42e

Extracellular Matrix

117

ECMExtracellular matrix (ECM) Surrounds many animal cellCarbohydrates and protein Fibronectins glycoproteins of ECM bind to integrinsIntegrins receptor proteins in plasma membrane

118

Proteoglycans Cartilage