CHAPTER 8 Part 3

Cytoplasmic Membrane Systems:

Structure, Function, and

Membrane Trafficking

Copyright © 2008 by John Wiley & Sons, Inc.

Why Study Endomembrane Systems, Vesicular Transport, and Protein

Modification and Trafficking?

• Only A general Idea • No Need to Memorize for Exam• Will discuss in the Lecture Class

what you need to take away from this section for Exam 2

Receptor-mediated Endocytosis

COATED PITS

Clathrin Triskelions

Molecular Organization of Coated Vesicles

Role of Dynamin in formation of clathrin coated vesicles

The Endocytic Pathway

LDL Cholesterol

Atherosclerosis

Initial Stages of receptor-mediated endocytosis of LDL particles are revealed by EM

Endocytic Pathway for internalizing LDL

Endocytic Pathway delivers Iron to Cells

Model of the mechanism for budding of HIV from the plasma membrane

EM of virus buddiing from wild-type (left) and ESCRT-deficient HIV-infected cells (right)

Influenza Virus Infection

Conformational Changes in Viral Envelpe proteins Triiger Membrane

Fusion

Hemagglutinin (HA) glycoprotein of influenza virus

Phagocytosis