CHAPTER 8 Part 3
Cytoplasmic Membrane Systems:
Structure, Function, and
Membrane Trafficking
Copyright © 2008 by John Wiley & Sons, Inc.
Why Study Endomembrane Systems, Vesicular Transport, and Protein
Modification and Trafficking?
• Only A general Idea • No Need to Memorize for Exam• Will discuss in the Lecture Class
what you need to take away from this section for Exam 2
Receptor-mediated Endocytosis
Clathrin Triskelions
Molecular Organization of Coated Vesicles
Role of Dynamin in formation of clathrin coated vesicles
The Endocytic Pathway
Initial Stages of receptor-mediated endocytosis of LDL particles are revealed by EM
Endocytic Pathway for internalizing LDL
Endocytic Pathway delivers Iron to Cells
Model of the mechanism for budding of HIV from the plasma membrane
EM of virus buddiing from wild-type (left) and ESCRT-deficient HIV-infected cells (right)
Influenza Virus Infection
Conformational Changes in Viral Envelpe proteins Triiger Membrane
Fusion
Hemagglutinin (HA) glycoprotein of influenza virus