CASE III PP Morbili [Repaired

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    MORBILI, BRONCHOPNEUMONIA, ACUTE

    DIARRHEA IN A CHILD

    By

    Mira Febriani Hontong

    Supervisor

    dr. Audrey Wahani, SpA(K)

    1

    June 2014

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    INTRODUCTION

    2

    Morbili (measles,

    rubeola)

    An acute

    contagious

    disease caused

    by an infection of

    morbilivirus

    Incidence in Indonesia from1990 to 2002 is appr. 3.000-

    4.000 cases a year

    Most common complications :

    Bronchopneumonia and

    gastroenteritis

    Self-limittinguncomplicated: supportive

    tx; complicated: antibiotics

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    INTRODUCTION

    3

    Bronchopneumonia

    Aninflammation

    on lungparenchyma

    Mostly caused by

    microorganism

    n morbili: caused by morbilivirusorby superimposed infection causedby other agents.

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    INTRODUCTION

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    Acute Diarrhea

    In infant orchildren

    defecation of>3x/day with achange in stool

    consistency, inwhich the stool

    may become softor even liquid

    In morbilli, diarrhea may result fromthe replication of morbilli virus

    inside the gastrointestinal tract.

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    CASE REPORT

    5

    RS, , 6months

    old

    Gorontalese

    admitted :May 29th,

    2014

    chiefcomplaints

    shortness ofbreath since

    1 day priorto

    admissionpreceded bycough andfever since

    1 weekprior to

    admission

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    Fever andcough (1

    week priorto

    admission)

    Shortnessof breath(1 dayprior to

    admission)

    Shortnessof breath,

    fever,cough

    Red rashes(1 dayafter

    admission)

    ADMISSION:

    May 29th

    ,2014

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    History of prenatal care and birthANC : regular , tetanus toxoid : twiceThis patient was born spontaneously

    aterm, birth weight was 3300 grams

    History of experienced illnessHe had history of diarrhea andseveral bouts of cough before

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    Family Tree

    8

    7/24/2014

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    Developmental milestonesSocial smile : 4 monthsTurning in prone position: 5 months

    Sitting : -

    Crawling : -

    Standing : -

    Calling mama/papa : 6 months

    Walking :-Normal according to thedevelopment age

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    History of feedingBreast feeding : birth6 months

    Formula milk : birth - 6 months

    Milk porridge : 5 months - present

    Soft rice porridge : -Rice : -

    Immunization

    he received basic immunization completely as

    recommended

    7/24/2014

    It is normal to his age

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    Social, economic and environmentfather 46 years old , a farmer, junior high

    graduate

    mother 34 years old, a housewife, junior high

    graduate

    They live in a permanent house 3 bedrooms,

    with 5 adults and 4 children

    In-house bathroom and lavatoryElectricity from government company

    Water from artesian well

    Wastes are collected and thrown away

    This patient is usingJAMKESMAS

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    Vital sign : Pulse rate : 130 times/minutes, regularly

    Respiratory rate : 40 times/minutesTemperature : 37.4 C

    Head : mesochepaly, thick black hair, not easily pulled

    out

    Eyes : conjungtiva was not anemic, sclera was not icteric,

    palpebral edema (-/-), facial edema (-), both pupil were round,

    same diameter with size of 3-3 mm, eyes reflexes were normal

    Ears : clear external ear canal, normal ear drumsNose : there was no secretes nor flares

    Mouth : there was no cyanosis, no signs of hyperemic

    pharynx nor both tonsils

    Neck : no lymph nodes enlargement

    Within normal limit

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    Chest : symmetrical respiratory movement, no

    retractions

    Heart : normal rate, regular rhythm, no murmur, no

    thrill

    Lungs : bronchovesicular breathe sound, no cracklesnor wheezing, rales +/+

    Abdomen : round, soft, normal bowel sound, liver and

    spleen were not palpable

    Extremities : warm, not cyanotic, capillary refill time lessthan 2 seconds, normal muscle tone, normal physiological

    reflexes and no pathological reflexes was found

    Genitalia :male, no abnormality

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    Laboratory and Diagnostic Workups

    (May 29th, 2014)

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    Malaria : -Haemoglobin : 10.3 g/dL

    Hematocrits : 30.8 %

    Leukocytes : 4.8 x 103/mm3

    Thrombocytes : 558 x 103/ mm3

    Sodium :129 mmol/LPotassium :4.6 mmol/L

    Chloride :103 mmol/L

    CRP : 12

    Plain chest X-ray : indicative of bronchopneumonia

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    Working diagnosis

    Bronchopneumonia

    Treatment

    Cefixime 2 x 35 mg pulv Paracetamol 3 x tsp

    Zinc 1 x 20 mg

    Oralyte 70-100 mL

    Nebulization with Ventolin R + 2,5 mL NaCL / 8 hours

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    Date ComplPhysic

    ExamLab Dx

    Tx

    05/30/13(2nd day)

    Fever (+),soft stool(+) onceRed rasheson skin (+)

    RR 38x/minPulse146x/minT 38.70C

    Chest :symmetrical,no retraction,no heartmurmur,bronchovesicular respiratorysound, no

    wheezing,rales +/+

    Other aspects ofexaminationswere withinnormal limit

    - Bronchopneumonia

    Acute

    Diarrhea

    withoutdehydration

    Hyponatremia

    Cefixime 2 x 35 mg pulv

    Paracetamol 3 x tsp

    Zinc 1 x 20 mg

    Oralyte 70-100 mL

    Nebulization with

    Ventolin R + 2,5 mLNaCL / 8 hours

    Salycil Talk 3 x app

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    Date CompPhysic

    examDx Tx

    05/31/14to06/01/14(3rd & 4thday)

    fever (+),Redrashes(+),shortness

    of breath(+)

    RR 60x/minPulse 144x/minT 37.90C

    Chest :

    symmetrical,retraction (+),no heartmurmur,bronchovesicular respiratorysound, nowheezing, rales

    +/+

    Others: WNL

    Bronchopneumonia

    Acute Diarrhea

    without dehydration

    Hyponatremia

    Morbilli

    Fecal Analysis

    (May 31st):

    pH: 7

    Color: yellowish

    Blood: -

    Leukocyte : 1-2

    Erythrocyte : -

    Epithelial cells: 1-2

    Cefixime 2 x 35 mg pulv STOP

    Paracetamol 3 x tsp

    Zinc 1 x 20 mg

    Oralyte 70-100 mL

    Nebulization with Ventolin R +

    2,5 mL NaCL / 8 hours

    Salycil Talk 3 x app

    Planning:

    Stop oral medications

    O2 1-2 L/min

    IVFD KaEn 1B (NS) 10-11 gtt/min

    Ampicillin inj. 4 x 150 mg i.v

    Chloramphenicol inj. 4 x 200 mg.i.v

    Consult tropical-infection division

    Close observation

    Move to isolation room

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    Date CompPhysic

    examDx Tx

    06/02/14(5th day)

    Fever (+),coughdecreased, redrashes (+)

    turningblackish,shortnessof breathdecreased

    RR 28x/minPulse 110x/minT 37.50C

    Chest :

    symmetrical,minimalsuprasternalretraction (+),no heartmurmur,bronchovesicular respiratory

    sound, nowheezing, rales+/+

    Status Localis:red rashesturning black onall bodysurfaces

    Bronchopneumonia

    Post-Acute Diarrhea

    without dehydration

    Morbili

    Hyponatremia

    O2 1-2 L/min

    IVFD KaEn 1B (NS) 10-11 gtt/min

    Ampicillin inj. 4 x 150 mg i.v (3)

    Chloramphenicol inj. 4 x 200 mg

    .i.v (3)

    Paracetamol 3 x tsp

    Zinc 1 x 20 mg

    Tropic feeding with 8 x 10 cc milk

    via NGT

    Planning

    Urinalysis

    Complete Fecal Analysis

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    Date CompPhysic

    examDx Tx

    06/03/14(6th day)

    Fever (-),coughdecreased, redrashes (+)

    turningblackishanddecreasing,shortnessof breathdecreased

    , no rapidbreathing,intake (+)

    RR 30x/minPulse 108x/minT 36.50C

    Chest :symmetrical,minimalsuprasternalretraction, noheart murmur,roughbronchovesicula

    r respiratorysound, nowheezing, rales+/+ minimal

    Status Localis:red rashesturning black onall bodysurfaces

    Bronchopneumonia

    Post-Acute Diarrhea

    without dehydration

    Morbili

    Hyponatremia

    Urinalysis :Molecular weight:1,005Leukocytes: 1-2Erythrocytes: 0-1Epithelium: 2-3Protein : -Billirubins: -Urobillins:normalBlood/erythrocytes: 0-1

    O2 1-2 L/min

    IVFD KaEn 1B (NS) 10-11 gtt/min

    Ampicillin inj. 4 x 150 mg i.v (4)

    Chloramphenicol inj. 4 x 200 mg

    .i.v (4)

    Paracetamol 3 x tsp

    Zinc 1 x 20 mg

    Tropic feeding with 8 x 10 cc milk

    via NGT gradual rapid increase to

    8 x 40-50 mL milk

    Try oral feeding today

    Attending Physicians Advice:Remove INT and NGTSwitch to oral antibiotic(Cefixime 2 x 40 mg pulv)Discharge tomorrow

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    Date CompPhysic

    examDx Tx

    06/04/14(7thday)

    Cough (-),shortnessof breath(-), rapidbreathing(-), fever(-), redrashes (+)turningblackishanddecreasing, intake

    (+)

    RR 28x/minPulse 110x/minT 36.30C

    Others: WNL

    BronchopneumoniaMorbiliHyponatremi

    a

    Cefixime 2 x 40 mg pulv

    Paracetamol 3 x tsp

    Zinc 1 x 20 mg

    Milk on demand

    Nebulization with Ventolin

    respule + 2.5 mL NS every 12

    hours

    Planing :

    Discharge

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    DISSCUSSION

    22

    Morbili

    Infectious disease coused bymorbilivirus

    Mainly affects children

    Classification Prodromal phase

    Eruption phase

    Convalescing phase

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    DISSCUSSION

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    Clinical Sympoms

    Prodromal phase:

    Cold

    Coughs

    Enanthema on cheek mucosa

    Inflammation on pharynx andconjunctiva

    Eruption phase

    Occurrences of rash

    Starting from the back of the ear, spreadingto face, trunk and extremities

    Preceded by increasing body temp

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    DISSCUSSION contIn this caseDx base :history, physical examination

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    History : fever and cough since 6 days before admission and thecough later accompanied by shortness of breath since 1 day prior toadmission. This clinical symptom indicative of a bronchopneumoniais also accompanied by cold, coryza and reddish coloration ofconjunctiva especially in the mornings indicative of a prodromalphase of morbilli.rashes then started to darken in color (hyperpigmentation) with milddesquamation starting day 4 of treatment, indicating that the patienthas entered the convalescence phase of morbilli

    PE: other than rales on both lungs, other aspects ofpatients physical examination were within normallimit

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    DISSCUSSION

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    It is known that morbilli maycause certain degree ofimmunosuppression, facilitatingthe occurrences of secondary

    infection or complications.

    The most common

    complications of morbilli isbronchopneumonia (75.2%) andgastroenteritis (7.1%)

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    Complication Disscussion cont

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    Defecation frequency of morethan 3 times in 24 hours with softstool consistency lasting less thana week.

    The invasion of virus into tointestinal mucosa yields in an

    inflammation on the mucosallayer which in turn causesdiarrhea and malabsorption.

    AcuteDiarrhea

    soft stool since 3 days prior

    to admission, with 5 times aday frequency

    No signs of dehydrationIn this patient

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    Complication Disscussion cont

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    inflammation on lungparenchyma.

    in morbili might be the result ofan infection by the morbilivirusitself or due to bacterial invasion.

    characterized by cough, increasedrespiratory frequency and wetsoft crackles (rales)

    Bronchopneumonia

    Cough, shortness of breath,rales

    X-ray confirms diagnosisIn this patient

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    Management Disscussioncont

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    Uncomplicated morbili treat asoutpatient, supportive treatment

    Complicated morbili treat asinpatients, consider antibioticadministration

    Manage

    ment

    Given antibiotics

    Symptomatic treatment for fever and cold symptoms

    Treated in isolation room due to the contagiousnature of the disease

    Inthispatie

    nt

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    Prevention Disscussion cont

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    The most effective way to prevent anderadicate morbilli is vaccination,

    may be given as both active and

    passive immunization

    Vaccination

    Not yet vaccinated (due to age)

    Explains the more severe clinical course compared toother cases

    Inthispatie

    nt

    P i

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    PrognosisDISSCUSSION cont..

    The prognosis is

    excellent if giventhe correct and

    rapid treatment

    This patients

    prognosis is

    good

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    TH NKYOU