HUMAN PAPILLOMA

VIRUS(HPV)

By,Acchaya Bajracharya & Veronika

Putzenlechner

INTRODUCTION HPV = Human Papilloma Virus More than 170 types of HPV Transferred via skin on skin contact Can lead to cancer Some types show symptoms, others do

not

WHAT IS IT? Non-enveloped DNA Virus Family: Papillomavirus family Establish only on basal keratinocytes of

skin/mucous membrane HPV types 6 and 11: cause genital warts HPV types 16 and 18: may progress to

precancerous lesions and invasive cancer

ETHIOLOGY (CAUSES AND TRANSMISSION) generally skin contact:

perinatalgenital infectionshandsshared objects (toys)bloodsurgery

SYMPTOMS Cancer Respiratory papillomatosis Immuno-comprimised Genital wart Skin warts

Types of warts: Common skin warts plantar warts subungual or periungual warts flat warts

CANCER

Incidence of HPV associated cancers in USA (2004-2008)

DEMOGRAPHY Estimated global prevalence = 11.7%

(women) Sub-Saharan Africa = 24% Eastern Europe = 21.4% Latin America = 16.1%

Highest percentage of cases of HPV in women

Type of cancer Deaths/year in US

Percentage due to HPV

Deaths/year in US due to HPV

anus 950 91% 870

cervix 4020 91% 3600

penis 320 63% 200

vagina 880 85% 750

vulva 1030 69% 710

total 7200 6130

Estimated deaths since 2014:• Worldwide = 536019• United States = 11139

PREVENTION Vaccine: Gardasil Gardasil 9 Cervarix

Education Social mobilization Screening Papillative care Use & promotion of safe sex – condoms Male circumcision

Protection against HPV types: 6, 11, 16 & 18

Protection against HPV types: 16 & 18

TREATMENT Currently no specific treatment for

HPV Virus normally clears by itself – within

2 years Genital warts:

Physical ablation – e.g. Excision, cryosurgery, etc.

Topical agents – e.g. 0.15–0.5% podophyllotoxin solution

Cancer: chemotherapy

FUTURE DRACO drug = early stages Alferon N = drug to treat genital warts Lopinavir = antiretroviral – of the

protease inhibitor class

BIBLIOGRAPHY https://en.wikipedia.org/wiki/Genital_wart https://en.wikipedia.org/wiki/Human_papillomavirus http://jid.oxfordjournals.org/content/202/12/1789.full http://www.cancer.gov/about-cancer/causes-preventi

on/risk/infectious-agents/hpv-fact-sheet#q4 http://www.who.int/immunization/topics/hpv/en/ http://www.nhs.uk/chq/Pages/2611.aspx http://www.kegel.com/hpv/deaths/

https://en.wikipedia.org/wiki/Papillomaviridae https://en.wikipedia.org/wiki/Human_papillomavirus http://www.who.int/mediacentre/factsheets/fs380/en/