Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation...

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cording and Analyzing EEG in Ambulato n Davis 1 , Beverly Sturges 2 , Charles H. Vit 5 , Andrew B. Gardner 6 , Ann Chamberlain Litt 1,7 Penn Epilepsy Center, Dept. of Neuro School of Veterinary Medicine, Unive School of Veterinary Medicine, Unive NeuroVista Corporation NeuroVista Corporation Mayo Clinic, Rochester MN Momentics Corporation Dept. of Bioengineering, University Brian L Associate Profess Associate Professor g Continuous Intracra ory Epileptic Dogs te 3 , Vanessa Ruedebusch 4 , Gregory n 7 , Kent Leyde 4 , W. Douglas Sheffield 4 , ology, University of Pennsylvania ersity of California Davis ersity of Pennsylvania of Pennsylvania Litt, MD sor of Neurology r of Bioengineering

Transcript of Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation...

Page 1: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

Recording and Analyzing Continuous IntracranialEEG in Ambulatory Epileptic Dogs

Kathryn Davis1, Beverly Sturges2, Charles H. Vite5, Andrew B. Gardner6, Ann Chamberlain

Brian Litt 1,7

Penn Epilepsy Center, Dept. of Neurology, University of PennsylvaniaSchool of Veterinary Medicine, University of California DavisSchool of Veterinary Medicine, University of PennsylvaniaNeuroVista CorporationNeuroVista CorporationMayo Clinic, Rochester MNMomentics CorporationDept. of Bioengineering, University of Pennsylvania

Brian Litt, MDAssociate Professor of Neurology

Associate Professor of Bioengineering

Recording and Analyzing Continuous IntracranialEEG in Ambulatory Epileptic Dogs

, Charles H. Vite3, Vanessa Ruedebusch4, Gregory, Ann Chamberlain7, Kent Leyde4, W. Douglas Sheffield4,

Penn Epilepsy Center, Dept. of Neurology, University of PennsylvaniaSchool of Veterinary Medicine, University of California DavisSchool of Veterinary Medicine, University of Pennsylvania

Dept. of Bioengineering, University of Pennsylvania

Brian Litt, MDAssociate Professor of Neurology

Associate Professor of Bioengineering

Page 2: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

The NeuroVista System

• 6 dogs• 6 dogs• Natural epilepsy• Automated alert• > 1 year• Sz detect/ predict• ? Treatment

The NeuroVista System

Page 3: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

ImplantationImplantation

Page 4: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

Normal SleepNormal Sleep

Page 5: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

Normal AwakeNormal Awake

Page 6: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

Focal IEDsFocal IEDs

Page 7: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

Focal Subclinical SeizureFocal Subclinical Seizure

Page 8: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

Focal and Diffuse Sz Onsetsuse Sz Onsets

Page 9: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

Sz Susceptibility & Treatment

Seizures

Susceptibilityparameter

Sz Susceptibility & Treatment

Pb administered

Page 10: Brian€Litt,€MDaz9194.vo.msecnd.net/pdfs/110404/01.04.pdfMomentics€Corporation Dept.€of€Bioengineering,€University€of€Pennsylvania Brian€Litt,€MD Associate€Professor€of€Neurology

Support

NeuroVistaNINDS (R01­NS041811­04, RO1The Dr. Michel and Mrs. Anna Mirowski Discovery Fund

Support

04, RO1­NS48598­01)The Dr. Michel and Mrs. Anna Mirowski Discovery Fund