Biomarkers and Drug Discovery• Angie Pannier

• Mathias Schubert

• Pat Dussault

• Surinder Batra

Charge:• Your task is to develop core ideas/projects for an $8-10M

($1.25-1.5M per year for 5 years) NIH Center proposal.

• Specifically, you should consider the following questions

Briefly describe the core projects your group would design for the Center. Please dream big.• Cancer diagnostics

– Noninvasive

• Imaging-based (small molecules)

• Blood-borne (cellular or molecular targets)

– Detection with nanoparticles and then novel characterization techniques (to determine presence of ligand)

– Nanohybrid materials--Biomolecule capturing/filtering/microfluidics/readout techniques

– Detection for proteins, miRNAs, small molecules

• Diagnostics/Disease Screening Center (broader than cancer)—” Nanohybrid Biomaterials for Diagnostics”

– Screen for miRNAs

– Sensitive RNA detection methods and probes

– Sequencing

– Profiles

– Bioinformatics

• Personalized Medicine

– Combine above with additional therapies

Identify the key faculty from both campuses to involve in these projects. Include their strengths. (UNMC on next slide)• UNL Faculty Strengths

• Pat Dussualt

• David Hage

• Mathias Schubert

• Angie Pannier

• Eva Bachman-Schubert

• Ravi Saraf

• Yongfeng Lu

• Rebecca Lai

• Hendrik Viljoen

• Yuris Dzenis

• Ming Han

• Srivatsan Kidambi

• Dennis Alexander

• Greg Bashford

• Shadi Othman

• Jung Yul Lim

Identify the key faculty from both campuses to involve in these projects. Include their strengths.• UNMC Faculty Strengths

• Surinder Batra

• Tony Hollingsworth

• Aaron Sasson

• Michelle Ouetllet

• John Davis

• Steve Remenga

• Subodh Lele

• Hamid Band

• Vimla Band

• Kay Wagner

• Ken Cowan

• CDDN (Sasha Kabanov and Tatiana Bronich)

• Sanjay Singh

• Howard Gendelman

• Ken Bayles

Identify external academic partners & expertise or equipment resources/strengths that are needed to accomplish these projects.

• Better communication between campuses (and PIs)

• Expand nanofabrication facilities (microelectronics, prototyping)

• Microfluidics faculty member

• New graduate program

List potential industry/foundation partners (think broadly) and what they would contribute. Include reasons why they would be interested.

• J.A. Woollam Co.

• LICOR

• P & G

• Abbott

• PanCan

• American Cancer Society

• All disease specific….

Describe how you would link the Center to other campus resources.• Links to CDDN, NCMN, MR-SEC, Center for

Biotechnology, Nebraska Gateway for Nutrigenomics, UNMC Bioinformatics, Center for Neurosciences, Genetics Center

Increase communication between campuses (intracampus)• “Stanford BioDesign” analogy

• Poster Sessions

• Research talks

• Biologists/clinicians: What are the problems?

• Engineers: What are the tools?