Ana Maria BetancurCristian Calle

Biología Molecular-Lína Martínez Febrero 19-2012

Hemoglobinopathy: Molecular EpidemiologicalCharacteristics and Health Effects on Hakka People in theMeizhou Region, Southern ChinaMin Lin1, Ying-Fang Wen2, Jiao-Ren Wu1, Qian Wang3, Lei Zheng3, Gui-Rong Liu2, Yue Huang1,Hui Yang1, Fen Lin1, Xiao-Fen Zhan1, Chun-Ping Lin1, Hui-Tian Yang1, Qiu-Qing Weng2, Fen-Ting Huang2,Yuan Wang4, Mei-Qiong Yao5, Hui-Zhou Chen6, Di-Hong Wu7, Jing-Bo Zeng8, Ri-Xin Zeng9, Hua Yang10,Gui-Cai Li1, Min Lu11, Juan-Juan Zhu11, Long-Xu Xie11, Jun-Li Wang12, Li-Ye Yang1*

Document the prevalence and molecular

characterization of hemoglobinopathies

in Hakka population of the Meizhou region.

Hemoglobin

Taken for:http://www.ecogenesis.com.ar/index.php?sec=articulo.php&Codigo=108.htm

Taken for: http://www.pacientesonline.com.ar/medicina/enfermedades/clinica/talasemia.php

Hemoglobinopathy

Taken for:http://www.whattoexpect.com/pregnancy/your-baby/week-27/sense-something.aspx

Figure 2. Diagram for the screening of hemoglobin variants, a/b-thalassemia and HPFH/db-thalassemia.doi:10.1371/journal.pone.0055024.g002

F. mutación de genes de cadenas

a-globina = 1.0861023, b-globina = 1,31. 61023(73/15299)

G / D (26,7%, 18/73) y de los grupos E (26,7%, 18/73) fueron los principales tipos de hemoglobina anormal.

Q (17,8%, 13/73) y grupo K (16,4%,

12/73).

F. mutación de genes de cadenas

a-globina = 1.0861023, b-globina = 1,31. 61023(73/15299)

277 casos de microcitosis (VCM, 82

fl)----------- de 15,89% (es decir,

277/1743).

Frecuencia heterocigótica de 11,24% -- A talasemia y B

talasemia en la región Meizhou

un 7,11% de la a-talasemia y 4,13% de b-talasemia

11 muestras tenían talasemia A y B

frecuencia de 0,63% (11/1743).

Hay supresión del Sea pa a- talasemia, y

supresión o deleccion de A3.7-A4.2

Resultados de la secuenciación de ADN de los 9 tipos de hemoglobina anormal (excepto HbE) .

Figure 3. Hemoglobin analysis of hemoglobin variants withcellulose acetate electrophoresis at pH= 8.6. The electrophoresisphenomenon includes H, J, K, Normal, F/Q, G/D and E.

Figure 5. Results of a and b thalassemia in gene chip. A: The results of a and b thalassemia in the gene chip; B: The location of the probesdotted in the gene chip used for the reverse dot blot assay. Locations of wild-type and mutant probes are denoted N and M, respectively.

Figure 6. Results of 2 cases of Vietnamese HPFH (FPFH7) were identified by Gap-PCR.

What said? Is true since the article??

Du RF, ed. (2004) The frequency of hemoglobin variantsin the Meizhou region is higher than the average of Guangdongprovince (0.368%, P,0.05).

Not

Xu XM, Zhou YQ, Luo GX, Liao C, Zhou M, et al.

Our study reveals a high prevalence of a/b-thalassemia in theregion, which is similar to the average level of Guangdongprovince (11.07%, P = 0.842).

Yes

Wang YZ, Jiang GA, Zhang JH, Su WJ, Chen HZ, et al.

The prevalence of hemoglobin variants in the Meizhou regionreported in this study (0.477%) is lower than that reported for thisarea 30 years ago (0.575%)

Not

Du RF, ed. (2004) In this study, the proportion of abnormal hemoglobin of the G/D group of the Hakka people in Meizhou is higher than that in thepearl river delta region, such as Guangzhou.

Yes

Is so important that in all countries, the scientist

begin to doing studies about this diseases,

because with this, we can get better information

about our people, and for this medium

determinate the prevalence and the frecuency of

the talasemias, and give a better explain and

treatments to the relational diseases.

Taken of : http://es.123rf.com/photo_4193149_caricatura-cientifico--ilustracion-vectorial.html

With the studies that was did, the scientists could get the variations in the hemoglobine, and wich were the estructural changes in each one of these, since some molecular testings.

Taken of: http://www.oni.escuelas.edu.ar/2011/SANTA_FE/1681/pagina_nueva_2.htm

The migration of the people, generated new

mutations in the hemoglobine, so if the

people travel around the world and live in

diferents countries, have a posibility of that

if have some type of talasemia, this going to

combine with other type of talasemia.

Taken of: http://desmotivaciones.es/tag/Chinos/6

In the families of now, the money is a difficult

topic, In some populations the difficulties are

largest, for this is so important that the

government, generate programs to help this

people, with money to the sick.

Taken of:http://www.tuscaloosada.com/office-divisions/restitution-recovery-unit/money/

Cristian Calle MenesesCristian Calle Meneses

Bibliography

•Hemoglobinopathy: Molecular EpidemiologicalCharacteristics and Health Effects on Hakka People in the Meizhou Region, Southern China, 01 February 2013, in http://www.ncbi.nlm.nih.gov/pubmed/23383304.

•MARTINEZ S. LINA MARIA, Biología molecular. 6 ed. Medellin; UPB.fac. de medicina 2011, p 10-14;42-55.