Protein Folding: Understanding the Dance of the Chaperones

and New Insights to the Function of Molecular Chaperones

Laura Segura MuñozMedicine student3er semester UPB

Teacher: Lina Mariia Martinez Sanchez

Aug. 27, 2012 Medellin

FOLDING

FOLDING

INTRODUCTION

Chaperones to work need a

previous function trigger factor

ensure that the protein is not

bad.

Chaperones are not just a class, there is

a variety that is more specialized

GroEL (E. coli)

PROTEIN FOLDING: UNDERSTANDING THA

DANCE OF THE CHAPERONES.

Science daily may. 8, 2012

PROTEIN FOLDING: UNDERSTANDING THA DANCE OF THE CHAPERONES.

• chaperones are a class of proteins that perform the folding of

proteins after their synthesis, three-

dimensional structure give.

PROTEIN FOLDING: UNDERSTANDING THA DANCE OF THE CHAPERONES.

chaperones have different families, these classifications are called chaperonins, GroEL is the one, and was discovered in E. Coli.

Chaperones GroEL helps when any protein can not fold while the folds 700 chaperone protein, GroEL alone the 1.

PROTEIN FOLDING: UNDERSTANDING THA DANCE OF THE CHAPERONES.

If not found GroEL, unfolded proteins accumulate, they generate long-term

problems, particularly neurodegenerative diseases.

OBSERVATION

I think the next step is to investigate the subtypes in

humans, we might have some more different than in the E. Coli easier to find

related pathologies accumulation of unfolded

proteins.

NEW INSIGHTS THE FUNCION OF MOLECULAR CHAPERONES

sCIENCE dailyAug. 24, 2012

NEW INSIGHTS THE FUNCION OF MOLECULAR CHAPERONES

Chaperones act after synthesis, but

immediately after synthesis acts trigger factor.

NEW INSIGHTS THE FUNCION OF MOLECULAR CHAPERONES

prepares the trigger factor for subsequent

protein folding chaperones by,

besides avoiding premature folding

during the synthesis, making proteins

restricting erroneous.

NEW INSIGHTS THE FUNCION OF MOLECULAR CHAPERONES

The trigger factor also has a component repair, if a protein synthesis and ends has a premature folding factor reverses it, to make way for the

chaperones for proper maturation.

OBSERVATION

More important that these chaperones, the trigger is the determinant factor in the maturation of proteins in the protein deficiency

diseases and could be the point of treatment to

improve the condition.

Medical utility

MEDICAL UTILITY

PROTEIN FOLDING: UNDERSTANDING THE DANCE

OF THE CHAPERONES

know that the chaperones have the assistance of chaperonins like GroEL,

is one possible way to classify diseases related to protein

maturation, but still need to do research to determine the classes of

chaperones in humans and to investigate much more about them

as they can that the variation between human and E. Coli can be

bigger.

MEDICAL UTILITY

PROTEIN FOLDING: UNDERSTANDING THE DANCE OF THE CHAPERONES

In neurodegenerative diseases (Alzheimer and Parkinson diseases) should assess the role of chaperonins like GroEL

of E. Coli, if there is a deficiency of said chaperonin proteins accumulate which could not be folded by the

chaperone protein level causing cerebral plaques.

MEDICAL UTILITY

NEW INSIGHTS TO THE FUNCTION OF MOLECULAR

CHAPERONES.

before a pathology level chaperones should be assessed first trigger

factor, because without chaperones would not

work, so they were structurally well.