Biologia molecular
-
Upload
caro-rave -
Category
Health & Medicine
-
view
196 -
download
6
description
Transcript of Biologia molecular
![Page 1: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/1.jpg)
Critical Pathway In Cell Cycle May Lead To Cancer Development and Bearing
Witness to the Phenomenon of Symmetric Cell Division
María Carolina Rave Aguirre
Medicine student
![Page 2: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/2.jpg)
![Page 3: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/3.jpg)
![Page 4: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/4.jpg)
INTRODUCTION
• Telomeres are small DNA sequences that shorten with each replication.
• The via of P53 can be used to intervene in the G1
checkpoint and also repair damage in the replication
of genetic material, preventing metastasis.
• Dynein protein has a great function is repaired the
asymmetry between cell division during mitosis.
![Page 5: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/5.jpg)
Critical Pathway In Cell Cycle May Lead To Cancer Development
Red OrbitJuly 11, 2013
Scientist findings on chromosome shortening suggest a potential target to arrest cancer cell growth.
The things findings about telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases.
![Page 6: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/6.jpg)
Telomeres have been compared to the plastic tips at the end of shoelaces because they prevent the ends of chromosomes from fraying and sticking to each other, which scrambles the genetic information and may promote cancer.
Critical Pathway In Cell Cycle May Lead To Cancer Development
![Page 7: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/7.jpg)
Cells can escape this fate by activating an enzyme called Telomerase, which prevents telomeres from getting shorter and the cells can continue growing and dividing.
Critical Pathway In Cell Cycle May Lead To Cancer Development
Each time a human cell divides, its telomeres become shorter. When they become too short, the cell can no longer divide.
![Page 8: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/8.jpg)
Scientists identified the p53 pathway, a molecular mechanism that normally protects a cell’s genetic material. It has a great role in the response to telomere desprotection.
If cells lose the function of p53, it can´t longer arrest cells in the G1 phase, an important point in the cell cycle for repairing DNA damage or, if the damage cannot be repaired, targeting the cell for programmed death.
![Page 9: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/9.jpg)
OBSERVATION
I think that is very important look more about telomeres and how they behave within the cell cycle, each day we will be closer to finding a possible cure for cancer. Thanks to this study people can learn more about different process to understand the exact way that alters the cycle of reproduction of cells for locked with certainty the step that fails in cycle checkpoints.
![Page 10: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/10.jpg)
Bearing Witness to the Phenomenon of Symmetric Cell Division
Science Daily
July 18, 2013
Dynein protein can be
correcting mistakes of symmetry in
the process of mitosis.
![Page 11: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/11.jpg)
An asymmetric cell division in not stem cells can give a result of two daughter cells with different fates, like one large cell that begin cell division early and other smaller than first cell and maybe can grows very slowly or dies.
Bearing Witness to the Phenomenon of Symmetric Cell Division
![Page 12: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/12.jpg)
In this fluorescent image the cells correct the symmetry problem adjusting its cell membranes relative to the spindle instead of shifting their spindles within the cell.
Cells with proper spindle alignment in early anaphase don´t this correction.
Early anaphase in magenta
Late anaphase in green
Bearing Witness to the Phenomenon of Symmetric Cell Division
![Page 13: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/13.jpg)
Dynein has an ability to drive movements for a new plasma membrane targeting mechanism in addition to the ones previously looked during metaphase.
Bearing Witness to the Phenomenon of Symmetric Cell Division
![Page 14: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/14.jpg)
OBSERVATION
In my opinion if be an asymmetric reproduction in the cells of the body can be altered many body functions that you do normal.For example, can reducing the number of functional cells, so it´s very important understand mechanisms used by the body for correcting the asymmetry at the time of cell division, so is possible intervene to improve them.
![Page 15: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/15.jpg)
MEDICAL UTILITY
Cancer is a disease that today hasn´t
cure, if people study more about telomeres and its role in the cell cycle, medicine could
find a way to fix up the errors that inducing
metastasis in the body.
![Page 16: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/16.jpg)
MEDICAL UTILITY
If the health people look at time the checkpoint that fails in the cancer cells, is possible search treatments for cancer and other diseases that
develop with these problems.Also maybe develop anti-aging treatments, but not from the
aesthetic, instead treatments for that the old people live your last years with a better quality of life
and greater vitality.
![Page 17: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/17.jpg)
MEDICAL UTILITYBearing Witness to the Phenomenon of Symmetric Cell
Division
Mechanism of action of the Dynein protein can use
to create treatments for people who have problems
in your replication of genetic material
symmetrically like children that can´t grow healthy by
this disease.
![Page 18: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/18.jpg)
If the body doesn´t has proteins like Dynein, it can´t
has a great homeostasis, because if doesn´t has
funtional cells the metabolism activities doesn´t do, and
people have metabolic diseases. For this reason is
very important know about the phenomenon of symmetric cell
division and innovate treatments.
MEDICAL UTILITYBearing Witness to the Phenomenon of Symmetric Cell
Division
![Page 19: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/19.jpg)
BIBLIOGRAPHY
MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7 ed. Medellín: UPB. Fac. de Medicina, 2013. 44-67 p.
Critical Pathway In Cell Cycle May Lead To Cancer Development. Red Orbit. (july 11, 2013)
Bearing Witness to the Phenomenon of Symmetric Cell Division. Science Daily. (july 18, 2013)
![Page 20: Biologia molecular](https://reader035.fdocuments.in/reader035/viewer/2022062419/5576db47d8b42a87588b4c7a/html5/thumbnails/20.jpg)
All knowledge has any value, there is nothing so small and insignificant that I don´t want to know
Ben Jonson