ABBRUZZESE, ALBERTO Diparti.ento di Biochi.ica e Biofisica Universit~ di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

ABU-ELHEIGA, L. Depart.ent of Molecular Biology Hebrew University, Hadassah Medical School P.O. Box 1172 Jerusalem, 91010 ISRAEL

AGOSTINELLI, ENZO Diparti.ento di Scienze Biochi.iche Centro di Biologia Molecolare del CNR Universit~ di Ra.a "La Sapienza" 00185 Rama, ITALY

ALHONEN, LEENA Depart.ent of Biocha.istry University of Kuopio P.O. Box 6

70211 Kuopio, FINLAND

ALISI, CHIARA Dipartt.ento di Biologia Vegetale Universit~ degli Studi di Ra.a "La Sapienza" Piazzale Aldo Moro, 5

00185 Ra.a, ITALY

ALTMAN, ARIE Otto Warburg Ctr. Biotechnol. in Agriculture The Hebrew University of Jerusala. P.O. Box 12

Rehovot, 76-100 ISRAEL

ALVES, PRAUKE Division of Gastroenterology • Endocrinology Depart.ent of Medicine Georg-August-University 3400 Gattingen, FRG

ANDERSSON, LEU C. Depart.ent of Pathology University of Helsinki 00380 Helsinki FINLAND

ANDREANA, AUGUSTO Diparti.ento di Terapia Medica I Facolt~ di Medicina Universit~ di Napoli 80134 Napoli, ITALY

ANGELINI, RICCARDO Diparti.ento di Biologia Vegetale Universit~ degli Studi di Ra.a "La Sapienza" Piazzale Aldo Moro, 5

00185 Roma, ITALY

ANTON, DAVID L. Central Research and Developaent E.I. du Pont de Neaours Co. Wilaington, DE 19898 USA

ASSARAF, Y.G. Depart.ent of Molecular Biology Hebrew University, Hadassah Medical School P.O. Box 1172 Jerusal .. , 91010 ISRAEL

BACCHI, CYRUS J. Haskins Laboratories Pace University 41 Park Row New York, NY 10038 USA

BACHRACH, URIEL Depart.ent of Molecular Biology Hebrew University, Hadassah Medical School P.O. Box 1172 Jerusal .. , 91010 ISRAEL

BAGNI, NELLO Departaent of Biology Institute of Botany Via Imerio, 42 40126 Bologna, ITALY

BAmlIROLI, BRUNO Cattedra di Biologia Molecolare Unlversit~ di Bologna Via Irnerio, 48 46126 Bologna, ITALY

769

BARKER, JACQUELINE H.A. Long Ashton Research Station

University of Bristol

Bristol, BS18 9AF

ENGLAND

BARNETT, GLENN R.

Department of Molecular Biology

and Biochemistry

University of California Irvine, CA 92717 USA

BASILION, JAMES P.

Department of Pharmacology

University of Texas

Medical School at Houston

Houston, TX 77225 USA

BASU, HIRAK S.

Brain Tu.or Research Center

Department of Neurological Surgery University of California, San Francisco

San Francisco, CA 94143 USA

BENINATI, SIMONE

Lab. of Cellular Development and Oncology

NIDR, National Institutes of Health Bldg. 30, Rm. 211

Bethesda, MD 20892 USA

BERGERON, RAYMOND J.

Department of Medicinal Chemistry

J. Hillis Miller Health Center

University of Florida

Gainesville, FL 32610 USA

BITONTI, ALAN J.

Merrell Dow Research Institute

2110 E. Galbraith Road Cincinnati, OH 45215 USA

BOWLIN, TERRY L.

Merrell Dow Research Institute

2110 E. Galbraith Road

Cincinnati, OH

45215-6300 USA

BROSNAN, MARGARET E.

Department of Biochemistry

Memorial University of Newfoundland

St. Johns, Newfoundland

AlB 3X9 CANADA

CACCIAPUOTI, GIOVANNA

Istituto di Biochimica delle Macromolecole

I Facolta di Medicina, Universita di Napoli

Via Costantinopoli, 16

80138 Napoli, ITALY

760

CALDARERA, CLAUDIO M.

Dipartimento di Biochimica

Universita di Bologna

Via Irnerio, 48

40126 Bologna, ITALY

CANDIANI, ROssELLA

Istituto di Patologia Generale, Universita, Centro Ricerca in Patologia Cellulare, CNR

Via Mangiagalli, 31

20133 Milano, ITALY

CANELLAKIs, E.s.

Department of Pharmacology

Yale University School of Medicine

New Haven, CT

06510-8066 USA

CANELLAKIs, ZOE NAKOS

Department of Pharmacology

Yale University School of Medicine

P.O. Box 3333

New Haven, CT 06510-8066 USA

CARRERA, CARLOS J.

Department of Basic and Clinical Research

Research Institute of Scripps Clinic

10666 North Torrey Pines Road

La Jolla, CA 92037 USA

CARSON, DENNIS A.

Department of Basic and Clinical Research

Research Institute of Scripps Clinic

10666 North Torrey Pines Road

La Jolla, CA 92037 USA

CARTENI'-FARINA, MARIA

Istituto di Biochimica delle Macromolecole

I Universita di Napoli

Via Costantinopoli, 16

80138 Napoli, ITALY

CAsTAGNINI, PAOLO Istituto di Chimica Biologica

Universita di Padova Via F. Marzolo, 3

35131 Padova, ITALY

CHATEL, M.

Groupe Recherche en Therap.Anticancereuse

Centre Hospitalier Universitaire

2. Ave. du Professeur Leon-Bernard

35043 Rennes Cedex, FRANCE

CHEN, H.J.

Department of Biological Sciences

and Chemistry

Northern Illinois University

DeKalb, IL 60115-2861 USA

CHIOCCA, ANTONIO Depart .. nts of Phar8acology and Medicine University of TeKas Medical School at Houston Houston, TX 77225 USA

CIMINO, GUIDO Istituto per la Chi.ica di lIolecole di Interesse Biologico, CNB Via Toiano, 6 80072 Arco Felice (Napoli), ITALY

CLAVERIE, NICOLE Merrell Dow Research Institute 16, rue d'Ankara 67084 Strasbourg Cedex FRANCE

CLEFFlIANN, ULRIKE Division of Gastroenterology & Endocrinology Departaent of Medicine Georg-August-University 3400 Gattingen, FRG

CLO', CARLO Diparti .. nto di Biochi.ica Facolta di Medicina e Chirurgia Via Irnerio, 48 40126 Bologna, ITALY

COHEN, PNINA Otto Warburg Ctr. Biotechnol. in Agriculture The Hebrew University of Jerusal .. P.O. Box 12 Rebovot, 76-100 ISRAEL

COLEMAN, CATHERINE S. Clinical Phar8acology Unit Depart.ent of Medicine & Terapeutics University of Aberdeen Aberdeen AB9 2ZD, SCOTLAND, UK

COLOMBATTO, SEBASTIANO Dipart. di Medicina e Oncologia Speriaentale Universita di Torino Via M. Buonarroti, 27 10126 Torino, ITALY

CONA, ALESSANDRA Diparti .. nto di Biologia Vegetale Universita degli Studi di Ra.a "La Sapienza" Piazzale Aldo Moro, 5 00185 Ra.a, ITALY

COURTHEOUX, P. Groupe de Recherche en Therapeutique Anticancereuse Centre Hospitalier Universitaire Caen, FRANCE

COWARD, JAMES K. Depts. of Ch .. istry and Medicinal Ch .. istry University of Michigan Ann Arbor, MI 48109-1055 USA

CREUTZFELDT, WERNER Division of Gastroenterology & Endocrinology Departaent of Medicine Georg-August-University 3400 Gattingen, raG

CROZAT, ANNE The Population Council and The Rockefeller University 1230 York Avenue New York, NY 10021 USA

DARCEL, F. Groupe Recherche en Therap.Anticancereuse Centre Hospitalier Universitaire 2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE

DAVIES, PETER J.A. Depart.ents of Phar8acology and Medicine University of Texas Medical School at Houston Houston, TX 77225 USA

DAVIS, ROWLAND H. Departaent of Molecular Biology and Bioche.istry University of California Irvine, CA 92717 USA

DE ROSA, MARIO Istituto di Biochi.ica delle Kac~lecole I Facolta di Medicina, Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

DELLA RAGIONE, FULVIO Istituto di Biochi.ica delle Macro.olecole I Facolta di Medicina, Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

DESIDERIO, ALPONSINA Istituto di Patologia Generale Universita di Milano Via Kangiagalli, 31 20133 Milano, ITALY

EISENBERG, LEONARD The Population Council and The Rockefeller University 1230 York Avenue New York, NY 10021 USA

761

ILOIlANTA, TIBHO Depart .. nt of Bioch .. istry University of Kuopio P.O. Box 6 70211 Kuopio, PINLAND

ISPOSITO, CARLA Diparti.ento di Biochi.ica e Biofisica I Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

PAIBLAMB, ALAN H. Depart.ent of Medical Protozoology London School of Hygiene • Tropical Medicine Keppel Street London WC11 7HT, INGLAND

PASULO, LUISA Dipart. di Medicina e Oncologia Speri.entale Universita di Torino Via M. Buonarroti, 27 10126 Torino, ITALY

PIDIBICO, BODOLPO Diparti.ento di Biologia Vegetale Universita degli Studi di ao.a "La Sapienza" Piazzale Aldo Moro, 5 00185 ao.a, ITALY

PIBIOLI, MARIA ELENA Istituto di Patologia Generale, Universita, Centro Ricerca in Patologia Cellulare, CNB Via Mangiagalli, 31 20133 Milano, ITALY

PEBRO, ADOLPH J. Epitope Inc. 15425 S.W. Koll Parkway Beaverton, OR 97006 USA

PEUIBSTEIN, BURT G. Departments of Laboratory Medicine and Pediatrics University of california, San Prancisco San Prancisco, CA 94143 USA

PIOBETTI, MASSIMO Istituto di Biocht.ica delle Hacro.o1ecole I Pacolta di Medicina, Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

PITCHEN, JOHN H. Medical Research Service Veterans Ad.inistration Medical Center P.O. Box 1034 Portland, OR 97207 USA

762

PLAKIGNI, FLAVIO Diparti.ento di Biochi.ica Universita di Bologna Via Irnerio, 48 40126 Bologna, ITALY

POLK, J.E. Lab. of Cellular Develop.ent and Oncology NIDB, National Institutes of Health Bldg. 30, ... 211 Bethesda, HD 20892 USA

POLSCH, ULRICH B. Division of Gastroenterology. Endocrinology Depart.ent of Medicine Georg-August-University 3400 GOttingen, PRG

PULGOSI, BARBABA Dipart. di Medicina e Oncologia Sperimentale Universita di Torino Via M. Buonarroti, 27 10126 Torino, ITALY

GALSTON, ARTHUR W. Department of Biology Yale University P.O. Box 666 New Haven, CT 06511 USA

GAHBACOBTA, AGATA Istituto per la Chimica di Molecole di Interesse Biologico, CNB Via Toiano, 6

80072 Arco Pelice (Napoli), ITALY

GAVAGNIN, MARGHEBITA Istituto per la Chi.ica di Molecole di Interesse B10logico, CNR Via Toiano, 6 80072 Arco Pelice (Napoli), ITALY

GEBHART, PRITZ Merrell Dow Besearch Institute 16, rue d'Ankara 67084 Strasbourg Cedex PIIANCE

GERNEB, EUGENE W. Department of Radiation Oncology and Bioch .. istry, University of Arizona Health Sciences Center Tuscan, AZ 85724 USA

GIPPIN, BRUCE P. Depart.ent of Biology University of Dayton 300 College Park Dayton, OH 45469-0001 USA

GOLENSIR, J. Departaent of Parasitology Hebrew University, Hadassah Medical School

P.O. Box 1172 Jerusala., 91010 ISRAEL

GONZALEZ-BOSCH, CARMEN Instituto Investigaciones Cito16gicas de la Caja de Ahorros de Valencia AIIadeo de Saboya, 4 46010 Valencia, SPAIN

GRAGNANIELLO, VINCENZO

Istituto di Biochimica delle Macromolecole I Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

GRILLO, HARIA ANGELICA Dipart. di Medicina e Oncologia Speri.entale

Universita di Torino Via M. Buonarroti, 27

10126 Torino, ITALY

GRISOLfA, SANTIAGO

Instituto Investigaciones Cito16gicas de la Caja de Aborros de Valencia Amadeo de Saboya, 4 46010 Valencia, SPAIN

GUARNIERI, CARLO Diparti.ento di Biocht.ica Universita di Bologna Via Irnerio, 48 40126 Bologna, ITALY

GUEGAN, Y. Groupe Recherche en Th~rap.Anticanc~reuse Centre Hospitalier Universitaire 2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE

GYNTHER, JUKKA

Depart.ent of Phar.aceutical Cha.istry University of Kuopio 70211 Kuopio FINLAND

HAKIM, GABRIELE Dipartimento di Biochimica

Universita di Bologna Via Irnerio, 48

40126 Bologna, ITALY

HAMASAKI, NOBUKO

Depart.ent of Life Science Tokyo Institute of Technology Nagatsuta, Midori-Ku Yokoha.a 227, JAPAN

HAVOUIS, R.

Groupe Recherche en Th~rap.Anticanc~reuse Centre Hospitalier Universitaire 2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE

HAYASHI, SHIN-ICHI Department of Nutrition

The Jikei University School of Medicine Minato-KU Tokyo 105 JAPAN

HEBY, OLLE

Department of Zoophysiology University of Lund Helgonar 3 233 62 Lund, SWEDEN

HERNANDEZ-YAGO, JOSt

Instituto Investigaciones Cito16gicas de 1a Caja de Ahorros de Valencia

Amadeo de Saboya, 4 46010 Valencia, SPAIN

HICKOK, NOREEN J. The Population Council and

The Rockefeller University 1230 York Avenue New York, NY 10021 USA

HICKS, M.F.

Depart.ent of Biological Sciences and Chemistry

Northern Illinois University DeKalb, IL 60115-2861 USA

HIRVONEN, ARI

Department of Biochemistry University of Kuopio P.O. Box 6 70211 Kuopio, FINLAND

HOUl, INGVAR Depart.ent of Zoophysio10gy UniverSity of Lund Helgonar 3 233 62 Lund, SWEDEN

HOLTTX, ERKKI Depart.ent of Pathology

University of Helsinki 00380 Helsinki FINLAND

HSIEH, J.T.

Depart.ent of Human Oncology University of Wisconsin

Clinical Cancer Center Madison, WI 53792 USA

763

HU, YU-WAN Department of Biochemistry

Me.arial University of Newfoundland St. Johns, Newfoundland AlB 3X9 CANADA

HUANG, S.C.

Department of Phar.acology Yale University School of Medicine New Haven, CT 06510-8066 USA

HYVONEN, TAPANI Department of Biochemistry University of Kuopio P.O. Box 6

70211 Kuopio, FINLAND

IGARASHI, KAZUEI Faculty of Pharmaceutical Sciences Inohana Campus, Chiba University 1-8-1 Inohana Chiba City, 280 JAPAN

ITO, KIYOSHI Faculty of Pharmaceutical Sciences Inohana Campus. Chiba University 1-8-1 Inohana Chiba City, 280 JAPAN

JXNNE, JUHANI

Department of Bioch .. istry University of Kuopio P.O. Box 6

70211 Kuopio, FINLAND

JXNNE, OLL! A. The Population Council and The Rockefeller University 1230 York Avenue New York, NY 10021 USA

JXRVINEN, TOMI Department of Pharmaceutical Chemistry University of Kuopio 70211 Kuopio FINLAND

JULKUNEN, MERVI The Population Council and The Rockefeller University 1230 York Avenue New York, NY 10021 USA

KAJANDER, E. OLAVI Department of Biochemistry University of Kuopio

P.O. Box 6 70211 Kuopio, FINLAND

764

KALKKINEN, NISSE Depart.ent of Gene Technology University of Helsinki Valimotie 7 00380 Helsinki, FINLAND

KALLIO, ARJA Orion

Genetic Engineering Laboratory Helsinki FINLAND

KAMEJI, T.

Department of Nutrition

The Jikei University School of Medicine Minato-KU Tokyo 105 JAPAN

KANAMOTO, R. Depart.ent of Nutrition The Jikei University School of Medicine Minato-KU Tokyo 105 JAPAN

KASHIWAGI, KEIKO Laboratory of Biochemical Pharmacology

NIDDKD, National Institutes of Health Bldg. 8, Rm. 223

Bethesda, MD 20892 USA

KAUPPINEN, LEILA Department of Biochemistry University of Kuopio P.O. Box 6

70211 Kuopio, FINLAND

KIERSZENBAUM, FELIPE Cellular I .. unology ~ I .. unoparasitology

Department of Microbiology ~ Public Health Michigan State University East Lansing, MI 48824-1101 USA

KRAKAMP", BERNHARD

1st Medical Clinic University of Cologne 5000 Koln-Merheim GERMANY

KUBOTA, HASARU

Department of Basic and Clinical Research Research Institute of Scripps Clinic 10666 North Torrey Pines Road La Jolla, CA 92037 USA

KUCAN, !'ELJKO

Department of Chemistry, Faculty of Science University of Zagreb Strossmayerov trg, 14

41000 Zagreb, YUGOSLAVIA

KULOHAA, HARKKU Depart.ent of Biomedical Sciences University of Taapere

P.O. Box 607 Taapere, 33101 FINLAND

KUSCHE, JURGEN Dr. Madaus GmbH & Co. Ostmerheimer Str.198

5000 Koln-9l GERMANY

KUTNY, RUSTY Central Research and Develo~ent E.I. du Pont de Nemours Co.

Wilmington, DE 19898 USA

KYRIAKIDIS, D.A. Laboratory of Biochemistry Faculty of Chemistry

University of Thessaloniki

Thessa1oniki, GREECE

LAPINJOKI, SEPPO Department of Pharmaceutical Cheaistry University of Kuopio

70211 Kuopio

FINLAND

LEISTEN, LOTHAR Department of Surgery University of Cologne

5000 Koln-Merhei.

GERMANY

LEVIN, NITSA Otto Warburg Ctr. Biotechnol. in Agriculture The Hebrew University of Jerusale.

P.O. Box 12 Rehovot, 76-100 ISRAEL

LIGUORI, V. Dipartimento di Biochi.ica e Biofisica

Universita di Napoli Via Costantinopoli, 16

80138 Napoli, ITALY

LINNALA-KANKKUNEN, ANNIKKA Department of Biochemistry University of Kuopio

P.O. Box 6 70211 Kuopio, FINLAND

LORENZINI, ERMA CECILIA Istituto di Patologia Generale, Universita,

Centro Ricerca in Pato1ogia Cellu1are, CNR Via Mangiagalli, 31

20133 Milano, ITALY

LOSER, CHRISTIAN

Division of Gastroenterology & Endocrinology Department of Medicine Georg-August-University

3400 GOttingen, FRG

MALORNI, A.

Istituto per 1a Chi.ica di Molecole di Interesse Biologico, CNR Via Toiano, 6

80072 Arco Felice (Napoli), ITALY

MAHONT, PIERRE S.

Merrell Dow Research Institute 16, rue d'Ankara

67084 Strasbourg Cedex FRANCE

/ MARCOTE, MARIA-JESUS Instituto Investigaciones Cito16gicas de la Caja de Ahorros de Valencia Amadeo de Saboya, 4 46010 Valencia, SPAIN

MARINO, GENNARO

Istituto di Chimica Organica e Biologica I Universita di Napoli

Via Mezzocannone, 16

80134 Napoli, ITALY

MARM I ROLl , SANDRA

Dipartimento di Biochimica

Universita di Bologna Via Irnerio, 48

40126 Bologna, ITALY

MARTON, LAURENCE J.

Dept. of Laboratory Medicine, and Brain Tumor Research Ctr, Dept. Neurolog. Surgery

University of California. San Francisco San Francisco, CA 94143 USA

MATSUFUJI, S.

Department of Nutrition

The Jikei University School of Medicine Minato-KU Tokyo 105 JAPAN

McCANN, PETER P.

Merrell Dow Research Institute 2110 E. Galbraith Road

Cincinnati, 08

45215 USA

MEGGIO, FLAVIO

Dipartimento di Chimica Biologica Universita di Padova

Via F. Marzolo, 3 35131 Padova, ITALY

765

KELANITOU, EVlE The Population Council and

The Rockefeller University 1230 York Avenue New York, NY 10021 USA

KENNINGEN, RUDOLF Departaent of Surgery University of Cologne 5000 K6ln-Kerhei. GERIfANY

IfETAFORA, SALVATORE International Institute of Genetics and Biophysics, cn Via lfarconi, 10 80125 Napoli, ITALY

KEZZETTI, GABRIELE Istituto di Chi.ica Biologica UniversitA di Kodena Via Campi, 287 41100 Modena, ITALY

MILLER, RICHARD L. Wellcome Research Laboratories 3030 Cornwallis Road Research Triangle Park NC 27709 USA

MINOCHA, SUBHASH C. Depart.ent of Botany and Plant Pathology University of New Hampshire Durba., NH 03824 USA

MIRALLES, VICENTE J.

Instituto Investigaciones Cito16gicas de la Caja de Ahorros de Valencia ~deo de Saboya, 4 46010 Valencia, SPAIN

KITCHELL, John L.A. Depart.ent of Biological Sciences and Ch_istry Northern Illinois University DeKalb, IL 60115-2861 USA

HONDOVI " BRUNO

Diparti.ento di Scienze Biochi.iche Centro di Biologia Ifolecolare del cn UniversitA di Ra.a "La Sapienza" 00185 Ra.a, ITALY

KONTI, KARIA GIUSEPPINA Istituto di Cht.ica Biologica UniversitA di Kodena Via Campi, 287 41100 Hodena, ITALY

766

!fORBIS, DAVID R. Depart.ent of Bioch .. istry University of Washington J405 Health Sciences Bldg., SJ-70 Seattle, WA 98195 USA

!fORUZZI, KARIA STELLA Istituto di Chi.ica Biologica UniversitA di Kodena Via Campi, 287 41100 Kodena, ITALY

MOULINOUX, JACQUES-PHILIPPE Groupe Recherche en Th'rap.Anticanc'reuse Centre Hospitalier Universitaire 2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE

MULLER, SYLKE Bernhard-Nocht-Institut fur Tropen.edizin Abteilung fur Bioch .. ie Bernhard-Nocht-Strasse 74 2000 Hamburg-4, GERlfANY

MURAKAMI, Y. Depart.ent of Nutrition The Jikei University School of Medicine Hinato-KU Tokyo 105 JAPAN

MURPHEY, ROBERTA J. Depart.ent of Radiation Oncology and Bioch .. istry, University of Arizona Health Sciences Center Tuscon, AZ 85724 USA

MUSTELIN, TOKAS Scripps Clinic and Research Institute 10666 North Torrey Pines Road La Jolla, CA 92037 USA

NADEL, BARRY

Otto Warburg Ctr. Biotechnol. in Agriculture The Hebrew University of Jerusal .. P.O. Box 12 Rehovot, 76-100 ISRAEL

NARANDA, TATJANA

Depart.ent of Ch .. istry, Faculty of Science University of Zagreb Strosa.ayerov trg, 14 41000 Zagreb, YUGOSLAVIA

NISHIYAIfA, H. Depart.ent of Nutrition The Jikei University School of Medicine Hinato-KU Tokyo 105 JAPAN

NOBORI, TSUTOHU Departaent of Basic and Clinical Research Research Institute of Scripps Clinic 10666 North Torrey Pines Road

La .Jolla, CA 92037 USA

NOTHIG-LASLO, VESNA Rugjer Boskovic Institute Bijenicka cesta 54 41000 Zagreb YUGOSLAVIA

NOVILLO, KARIA CRISTINA Istituto di Cht.iea Biologiea Universit~ di Padova Via F. Karzolo, 3 35131 Padova, ITALY

NUTTALL, KAIIK E.

Clinical Pbaraacology Unit Depart.ent of Hedicine & Terapeutics University of Aberdeen Aberdeen AB9 2ZD, SCOTLAND, UK

OGASAWARA, TOSHIHIRO Faculty of Pbaraaceutical Sciences lnobana C.-pus, Chiba University 1-8-1 Inobana Chiba City. 280 JAPAN

OLIVA, ADRIANA Istituto di Biocht.ica delle Hacroaolecole I Facolt~ di Hedicina, Universit~ di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

OSHIMA, TAIRO Departaent of Life Science Tokyo Institute of Technology Nagatsuta, Hidori-Ku Yokoba.a 227, .JAPAN

PAJUNIN, ANTTI Depart.ent of Bioch"istry University of Oulu LilllUl.-aa 90570 Oulu, FINLAND

PALIIKBO, ROSANNA Istituto di Biocbi.ica delle Kacroaolecole I Facolt~ di Hedicina, Universi~ di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

PANAGIOTIDIS, C.A. Depart.ent of Pbaraacology Yale University School of Medicine New Haven, CT 06510-8066 USA

PAlIK, IlYUNG HEE Lab. of Oral Biology and Physiology NIDR, National Institutes of Health BIdS 30, .. 211 Bethesda, KD 20892 USA

PIGG, ANTHONY E. Departaent of Physiology Hilton S. Hershey Hedieal Center Pensylvania State University Hershey, PA 17033 USA

PERIN, ANTONIO Istituto di Patologia Generale Universi~ di Hilano Via Kangiasalli, 31 20133 Hilano, ITALY

PERSSON, LO Departaent of Physiology University of Lund Helgonar 3 233 62 Lund, SWEDIN

PES SA , TIINA Depart.ent of Pathology University of Helsinki 00380 Helsinki FINLAND

PICCININI, GIORGIO Istituto di Cht.ica Biologica Universit~ di Modena Via c..pi, 287 41100 Hodena, ITALY

PINNA, LORINZO A. Diparti .. nto di Cht.ica Biologiea Universit~ di Padova Via F. Karzolo, 3 35131 Padova, ITALY

PISTOCCHI, ROSSELLA Depart .. nt of Biology Institute of Botany Via Imerio, 42 40126 Bologna, ITALY

PLOHL, HIROSLAV Rugjer Boskovic Institute Bijenicka cesta 54 41000 zasreb YUGOSLAVIA

PODDAR, SUSltITA Departaent of Pbaraacology University of Texas Hedical School at Houston Houston, TX 77225 USA

767

PONG, R.C. Depart_ent of Huaan Oncology University of Wisconsin

Clinical Cancer Center Madison, WI 53792 USA

PONTON I , GABRIELE Istituto di Biochimica delle Macromolecole I Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

PORCELLI, MARINA Istituto di Biochi.ica delle Macromolecole I Facolta di Medicina, Universita di Napoli

Via Costantinopoli, 16 80138 Napoli, ITALY

PORTA, RAFFAELE Dipartimento di Biochimica e Biofisica

I Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

PORTER, CARL W. Grace Cancer Drug Center

Roswell Park Memorial Institute 666 Elm Street Buffalo, NY 14363 USA

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2110 E. Galbraith Road Cincinnati, OH

45215-6300 USA

PUCCI, PIERO Istituto di Chi_ica Organica e Biologica I Universita di Napoli

Via Mezzocannone, 16 80134 Napoli, ITALY

QUEMENER, V. Groupe Recherche en Therap.Anticancereuse Centre Hospitalier Universitaire

2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE

RICCIO, PIERLUIGI Dipartimento di Scienze Biochimiche Centro di Biologia Molecolare del CNR Universita di Ra.a "La Sapienza" 00185 Boma, ITALY

RISCOE, MICHAEL K.

Medical Research Service Veterans Administration Medical Center P.O. Box 1034

Portland, OR 97207 USA

768

RISTOW, JANET L. Department of Molecular Biology

and Biochemistry

University of California Irvine, CA 92717 USA

ROMANO, TERESA Istituto di Biochimica delle Macromolecole

I Facolta di Medicina, Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY

RUGGIERO, GIUSEPPE Dipartimento di Terapia Medica

I Facolta di Medicina Universita di Napoli 80134 Napoli, ITALY

RUSSO, GIAN LUIGI Istituto di Biochimica delle Macromolecole

I Facolta di Medicina, Universita di Napoli Via Costantinopoli, 16

80138 Napoli, ITALY

SACCHI, PIETRO

Dipartimento di Biochi.ica

Facolta di Medicina e Chirurgia Via Irnerio, 48

40126 Bologna, ITALY

SAKAI, YUKO Faculty of Pharmaceutical Sciences

Inohana Campus, Chiba University 1-8-1 Inohana Chiba City, 280 JAPAN

SCALABRINO, GIUSEPPE Istituto di Patologia Generale, Universita, Centro Ricerca in Patologia Cellulare, CNR Via Mangiagalli, 31 20133 Milano, ITALY

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Universita di Milano Via Mangiagalli, 31 20133 Milano, ITALY

SILIPBANDI, DAGHAR Istituto di Chi.ica Biologica Universita di Padova Via F. Marzolo, 3 35131 Padova, ITALY

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SINERVIRTA, RIITTA Department of Biochemistry University of Kuopio P.O. Box 6 70211 Kuopio, FINLAND

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STANLEY, BRUCI Department of Pharmacology Milton S. Hershey Medical Center Pensylvania State University Hershey, PA 17033 USA

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XI!, Q.-W.

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ZWOLSHEN, JOHN H. Merrell Dow Research Institute 2110 E. Galbraith Road Cincinnati, OH 45215-6300 USA

AcetylCoA:spermidine N8-Acetyltrans­ferase (nSAT) ,

nuclear, 127-130, 137-140 AcetylCoA:spermidine/spermine N1-ace­

tyltransferase (cSAT), cytosolic, 128, 137, 331-341 estrogenic control in rat uterus,

345-351 in uterus during estrous cycle,

347-348 Acetylpolyamines,

in human cancer cells, 331-344 in plants and fungi, 582-583

N1-Acetylspermidine, excretion, 135-138 in human cancer cells, 335-339 in human lymphocytes, 509-512 and polyamine degradation,130-138, in sea urchin embryos, 426

N1-Acetylspermine, and polyamine degradation, 130,

135, 138 Acetyltransferase (see AcetylCoA:­

spermidine/spermine N1-ace­tyltransferase)

Acidothermophilic archaebacteria, AdoMet decarboxylase, 91-100 Wlusual polyamines, 633-642

Actin, 310 ADC (see Arginine decarboxylase) S-adenosyl 1,8-diamino-3-thiooctane

(AdoDAro) , effect on propylamine transferase,

119 S-adenosyl 1,12-diamino-3-thio-9-

azadodecane (AdoDATAD), effect on propylamine transferase,

119 S-adenosylmethionine decarboxylase

(AdoMet-DC) , androgen regulation of mRNA, 8-9 degradation, 267 in E. coli, 74-77, 83-85 effect on DNA methylation, 291-299 in gastrectamized rats, 370-375 half-life, 87-88

AdoMet-DC (cont'd.) inhibition by fluorinated analogs,

693-696 mechanistic properties, 85-87 mRNA, 266 proenzyme, 74, 77 properties in mammals, 101-109 pyruvoyl group generation, 82-85 regulation, 265 in SaccharomYces cerevisiae, 74-77 in Sulfolobus solfataricus, 91-100 structural properties, 83-85 substrate inactivation, 85-87 synthesis, 266 translational control, 244-245

Adenylate cyclase, regulation by polyamines, 535-543

AdoMet-DC (see S-adenosylmethionine decarboxylase )

African trypanosome, gr()\vth and transformation, 651-663 ODC in, 727-735

Agmatine, and DAD, 576-580

Agmatine ureohydrolase, of E. coli, 13-24

Aldehyde(s) , dehydrogenase, 152-153 formation, 152-153

AHA [see S- ( 5 '-deoxy-5 '-adenosy l)­methyl thioethy lhydroxy lamine]

Amiloride, and polyamine uptake, 512-514

Amine metabolism, 147-161 Amine oxidase regulation,

biological fWlctions, 147-161 Aminoaldehyde(s), 152, 154 Aminoguanidine,

large bowel cancer promotor, 751 Androgen(s) ,

regulation of ODe, 1-11 Antimalarial drugs, 199 Antiprotozoal drugs, 202 Antitumor activity,

of fluorinated spermidine analogs, 691-706

771

Antitumor activity (cont'd.) of norspermidine, 707-716 of polyamine analogs, 687

Antizyme (see also OOC antizyme), acidic, 13-24 biochemical assay of, 37-38 eDNA, 32 immunological detection of, 38-41 inhibitor, 32-33 as modifier protein, 41 in mouse kidney, 25-35 mRNA, 33 specificity, 64-66 tissue distribution, 38-40

Apoptosis, and transglutaminase, 399

Archaebacteria, and AdoMet-OC, 91-100 and unusual polyamines, 633-642

Arginase, activity in resistant myeloma

cells, 253-254 Arginine decarboxylase (ADC),

estimation, 573-583 antizyme, 13-24 in trypanosomes, 727-735

Auxin, and somatic embryogenesis in

plants, 607-609

N1,N 8-bis-alkylspermidine, 130 N',N'-bis-Allenylputrescine,

and polyamine interconversion, 131, 137-140

N1,N 12 -bis(ethyl)homospermine (BEHSm) , and polyamine enzymes, 677-690

N1,N 8-bis(ethyl)spermidine (BES) , and polyamine enzymes, 677-690

Nl ,N12 -bis (ethyl) spermine (BESm) , and polyamine enzymes, 677-690

Bovine liver, MTA phosphorylase, 187-198

Brain tumors, 353-363 Breast cancer cells, 332, 335, 339

Cadaverine, anabasine biosynthesis and, 548 and DAO, 575

Calcium, binding to liposomes, 491-496 cycling, 491-496 and polyamine uptake in plants,

553-554 Caldopentamine,

in thermophiles, 633-642 Calmodulin, 241-252 Camostate,

and pancreatic growth, 379-387 Cancer promotion,

712

Cancer promotion (cont'd.) and DAO activity, 745-752 and SAO activity, 150

Carcinogenesis, and DAO activity, 747, 750-751

Casein kinase-2, and ODe phosphorylation, 46-48

Cations cycling, and spermine, 491-496

eDNA of OOC, 1-11 eDNA antizyme

from rat liver, 32 Celery cell culture,

embryogenesis and polyamines, 567-569

CHA (see Cyclohexy lamine) Chemotherapy,

of filarial infections, 737-743 Chirally deuterated substrate,

of propylamine transferase, 112 Cholecystokinin,

in pancreatic growth, 379-387 Crithidia fasciculata,

regulation of spermidine levels, 667-674

Cross-linking reactions of proteins, 391-395, 399

cSAT (see AcetyICoA:spermidine/sper­mine Nl-acetyltransferase)

Cyclohexylamine, effect on OOC activity, 29 effect on OOC-antizyme complex,

31-32 in plant cultures, 561-563

DAO (see Diamine oxidase) Decarboxylated S-adenosylmethionine

(dcSAM), 91-100, 128, 131 effect on DNA methylation, 291-294 metabolism, 101

Deoxyhypusine synthesis, 436-447, 449-458

Deoxyhypusine hydroxylase, 449-466 5'-Deoxy-5'-methylthioadenosine (see

Methylthioadenosine) S-(5'-deoxy-5'-adenosyl)-methylthio­

ethylhydroxylamine (AMA), 102-104, 681-683, 686

5 '-Deoxy-5'-[N-methyl-N-[2-(amino­oxy)ethyl]]aminoadenosine (MAOEA) , 102-104

5'-Deoxy-5'-[N-methyl-N-(3-hydra­zinopropyl)]aminoadenosine (MHZPA) , 101-109

9-[5'-Deoxy-5'(methylthio)~-D-xylo-furanosyl]adenine, 219-228

Diacylglycerol, 481 -490 Diamine oxidase,

activity level, 147-161 in carcinogenesis, 745-752

Diamine oxidase (cont'd.) in fungi, 582-583 in human mucosa and polyps, 749-750 in large bowel cancer tissue,

748-749 in plants, 573-579 regulation, 155-156

1,3-Diaminopropane, in plants and fungi, 582-583

Diazabicyclononane, in plants, 573-587

Difluoromethylarginine (DFMA) , in cell cultures, 731-735 T. cruzi, 731-735 phytopathogens, 589-599 in plant cultures, 561-564

a-Difluoromethylornithine (DFMO), and acute infections of T.b.brucei,

655-659 and AdoMet-DC synthesis, 265-267 and cell differentiation, 291 in cell cultures, 261-272, 452-458 inactivation of ODC, 55-70 labeling of ODC, 55-70 on malaria parasites, 643-650 and pancreatic adaptation, 379-387 and phytopathogens, 589-599 in plants cultures, 561-564, and P. berghei, 722-723 and polyamine interconversion, 136-

139 in resistant human myeloma cell

line, 253-260 as trypanocidal agent, 667-674 and trypanosomiasis, 602-603,

727-735 6,6-Difluorospermidine, 691-706 7,7-Difluorospermidine, 691-706 2 ,4-Dinitrophenol ,

and polyamine uptake, 513-514 DFMA (see Difluoromethylarginine) DFMO (see Difluoromethy lorni thine) DNA methylation,

effect of dcAdoMet, 291-299 DNA methyltransferase,

from human placenta, 294-297 DNA/polyamine interactions, 517-524 DNA polymerases,

in malaria-infected erythrocytes, 643-650

DNA synthesis, in malaria-infected erythrocytes,

643-650 Doris verrucosa,

and MTA analog, 219-228

eIF-4D (see Eukaryotic initiation factor 4D)

Erythrocyte polyamine levels, in human neuro-oncology, 353-363

Erythrocyte poly. levels (cont' d. ) in malignant glioma patients,

353-363 17-~-Estradiol, 347 Estrogens,

and polyamine metabolism, 345, 356 Estrous cycle, 348 Ethionine,

and growth inhibitors, 205 Ethylene biosynthesis,

and polyamines in plants, 601-609 Ethylthioribose,

effects on protozoa, 203-204 mechanism of action, 204-205

Eukaryotic initiation factor 4D, 435-447, 449-458, 459-466

precursor, 435-447 Extreme thermophile,

and AdoMet-DC, 91-100 and unusual polyamines, 633-642

Fast atom bombardment mass spectro­metry (FAB-MS), 403-409

Filarial worms, polyamine metabolism, 737-743

Fluorinated analogs of spermidine, biochemical and biological acti­

vities, 691-706 (E)-2-(fluoromethyl)dehydroornithine,

inhibition of ODC, 692 5-Fluoromethylornithine,

and spermidine turnover, 131 Forskolin,

and adenylate cyclase activity, 535-543

Fungal growth inhibitors, 589-598 Fungi,

di- and polyamine oxidation, 582-583

Fusion of liposomes, 481-490

Giardia lamblia, and MTR kinase, 201 and MTR analog, 202

G-proteins, and ODC activation, 301-313

Gene, amplification, ODe, 253-255 expression, ODC, 1-11 expression, polyamine, 754 methylation, 258-260 transcription, ODC, 273-290

Genetic code, misreading of, 531

Genetic variation of ODC, 6-8 y-glutamyl,

putrescine, 393-395 spermidine, 393-395, 403-409 spermidine derivatives, 403-409 spermine, 393-395

773

y-glutamyl crosslinks, in epidermal cell envelopes,

417-420 y -glutamyl polyamines,

in cultured cells, 414-418 identification, 412-413 in mammalian tissues, 413-414 quantification, 412-413

Glutathionylspermidine, in trypanosomatids, 667-672

Glycolysis, effect of polyamine uptake,

512-514 Gramineae,

PADs in, 617-622 Growth,

of plants, and polyamines, 559-572 regulation of, in trypanosomatids,

667-672 regulation of polyamine biosynthe­

sis, 241-252 GTP analogs,

and adenylate eye late activity, 535-543

Guanine nucleotide binding proteins, 535-543

Guazatine, fungicide, 582 and hypusine biosynthesis, 454

Heart cell cultures, and adenylate cyclase activity

regulation, 535-543 (2R,5R)-6-Heptyne-2,5-diamine (MAP),

inhibition of polyamine biosyn­thesis, 696-702

Hexamethylenebisacetamide, effects on murine splenic

lymphocytes, 427, 432 Histidine decarboxylase, 81-89 HMBA (see Hexamethylenebisacetamide) HTC cells, 55-70, 691-706 Human cancer cells,

and polyamine recycling enzymes, 331-344

Human liver MfA phosphorylase, 211-217

Human mucosa DAD activity, 749-750 Human placenta KI'A phosphorylase,

165-178 Human serum MfA, 229-238 Hydrogen peroxide,

metabolic effects, 154 Hypusine,

biosynthesis, 435-447, 449-458, 459-466

in cultured cells, 414-418

Inositol, 301-313

774

Interconversion of polyamines, 127-145

Intestinal adaptation, 379 Intestinal mucosal hyperprolife­

ration, and DAD activity, 745-752

Lactate formation, 513-515 Large bowel tumor,

promotion by DAO inhibition, 745-752

Leishmania donovani, 211-217 Leukemia, 179, 258-260 Liposomes,

and polyamines, 469-480, 481-490 Lymphocyte mitogenesis, 301-313 Lysine decarboxylase, 548-557

Macrophage, activation by TGase, 398

Malaria, DFMO effects, 643-650 DNA synthesis in malaria-infected

erythrocytes, 643-650 and polyamine analogs, 717-726 and MTR kinase, 199-210

Mamnary gland, antizyme in, 38-40

MAO (see Monoamine oxidase) Membrane,

interaction with polyamines, 481-490

Messenger RNA (mRNA) , of ODC, 1-11, 18, 241-252, 262-265

Methionine, recycling pathway, 200

Methylglyoxal-bis(guanylhydrazone), (MGBG) ,

and AdoMet-DC regulation, 101-109, in plant cultures, 562-564 in polyamine recycling enzymes,

337-341 and transport of spermine across

membrane, 491-496 S-methyl-5'-(methylthio)adenosine,

(see Methylthioadenosine) Methylthioribose (MTR),

analogs, effects on protozoa, 199-210

kinase, and antiprotozoal drugs, 99-210 in protozoa, 199-210

Methylthioadenosine (MfA), analog, 219-228 in Doris verrucosa, 219-224 effect on AdoMet metabolism, 182 effect on diphtamide synthesis, 182 effect on polyamine metabolism, 181 metabolism, 756 in protozoa, 200-201

MTA (cont'd.) toxicity, 183-184

MTA nucleosidase, in protozoa, 201-202

MTA phosphorylase, antisera, 187-198 in bovine liver, 187-198 deficiency, 179-185 in Doris verrucosa, 223 in human placenta, 165-178 in human serum, 229-238 kinetics of, 165-178 as marker in acute hepatitis,

229-236 physico-chemical and immunological

properties, 187-198 in protozoa, 211-217 substrate specificity, 165-178

MI'R ( see Methyl thioribose) Methylthioxylofuranosyl adenosine,

219-228 t-GBG (see Methylglyoxal-bis(guanyl­

hydrazone) Mitochondrial proteins,

transport, 497-508 Molecular modeling,

polyamine DNA interactions, 517-521

Monoamine oxidase, activity, 151-152 tissue distribution, 148

Monofluoromethyl agmatine (FMAG), effect on trypanosomes, 731-733

Monofluoromethyldehydroarginine (.1-MFMA) ,

effect on trypanosomes, 731-735 6-Monofluorospermidine,

inhibition of ODe, 691-706 6-Monofluorospermine,

inhibition of one, 691-706 7-Monofluorospermidine,

inhibition of ODe, 691-706 Morris hepatoma, 700-703 mRNA (see Messenger RNA) MTA (see Methylthioadenosine) Mucosal hyperproliferation,

and DAD activity, 750-751

Nematodes, polyamine metabolism, 737-743

Neurospora eras sa , polyamines and one activity,

627-632 Norspermidine (Nspd) ,

antitumor activity, 707-716 nSAT (see AcetylCoA:spermidine N8_

acetyltransferase),

ODe (see Ornithine decarboxylase)

OCT (see Ornithine carbamoyltrans­ferase)

o. malhamensis, and MI'R analogs, 202

Oncogene transfection, and polyamine analogs, 686-687

Ornithine carbamoyltransferase pre­cursor,

transport, 497-508 Ornithine decarboxylase,

activation during lymphocyte mitogenesis, 301-313

activity in spinal cord, 365-378 androgen regulation, 1-11 and casein kinase 2, 46-48 control in N. crassa, 628-630 decay rate, 25-35 degradation, 261-271 erythroleukemia cells, 48-50 in fungi and higher plants,

589-599 gene amplification, 253-257 growth control, 242-244 in HTC cells, 57 human gene methylation, 258-260

in leukemia, 258-259 human gene structure, 253-257 in human myeloma cells, 253-260 induction by TPA, 273-290 modifications, 55-70 mRNA, 1-11, 18, 241-252, 262-265, multiple forms, 55-70 and norspermidine, 709 in pancreatic adaptation, 379-387 phosphorylation, 45-53, 55-70 and polyamine metabolic cycle,

128-136 post-transcriptional stabilization,

243 in rat heart, 45 regulation, 261, 45-53

inhibition by fluorinated polyamine analogs, 691-706

SH groups, 49-51 spermidine-induced modifications,

69-70 stabilization, 25-35 synthesis, 262-265 and thioredoxin, 43 transcription, 243 translational control, 245 in trypanosomes, 717-735

one antizyme (see also Antizyme), 13-24, 25-35, 38-41, 55-66

Ornithine:2-oxoacid aminotransferase (OAT) ,

and polyamine metabolic cycle, 128, 131

Ouabain, and polyamine uptake, 512-514

Oxidized polyamines, 147-161

775

Pancreas, antizyme in, 38-41

Pancreatic adaptation, role of ODC in, 379-387

Parasitic diseases, and MTR analog, 199-210

Pernicious anemia (PA) , 365-378 Phosphatase,

and ODC activity, 55-70 Phosphatidylethanolamine,

interaction with polyamines, 481-490

Phosphatidylcholine, 481-490 Phosphatidylinositol,481-490 Phosphatidylserine, 481-490 Phosphatidic acid, 481-490 Phospholipids,

and protein kinase C, 469-480, interaction with polyamines,

481-490 Phosphorylation,

of ODC,45-53, 55-70 of proteins and polyamines,

469-480, Phytopathogen,

polyamine biosynthesis inhibition, 589-598

PKC (see Protein kinase C) Plants,

cell cultures, 559-572 diamine oxidase, 573-580 DFMA effects, 561-563 embryogenesis, 567-569 ethylene biosynthesis, 601-609 growth and polyamines,547, 558,

559-572, hormones, 559-564 nitrogen nutrition, 561-564 pathogenes and polyamine biosyn-

thesis inhibitors, 590-598 polyamine distribution, 551-553 polyamine oxidases, 582-583 and polyamine uptake, 548-557 salt stress, 565-566

Plasmodium berghei, growth inhibition by polyamine

analogs, 722-723 and MTR analogs, 199-210

Plasmodium falciparum, cell cycle and polyamines, 643-650 cultures; polyamine analog effects,

717-726 drug-resistant, 199-210 growth inhibition by polyamine

analogs, 719-721 Polyamines,

catabolism, 127, 134, 138 in cell cycle of malaria parasite,

643-650 conjugates, 393-395, 403-409, 411-

776

Polyamines (cont'd.) 422, 755

cross-linking in epidermal cell envelopes, 417-420

in erythrocytes of glioma patients, 353-363

and ethylene biosynthesis in plants, 601-609

excretion, 137-138 in filarial worms, 737-743

fluorinated analogs, 691-706 in growth and differentiation of

plant cells, 559-572 in human cancer cells,131-140 in human neuro-oncology, 353-363 in hypusine biosynthesis, 435-447,

449-458 -induced protein, of E. coli,

315-320 jnhibitors, 677-690, 754-755 in malignant glioma patients,

353-363 in Neurospora crassa, 630-631 and somatic embryogenesis in

plants, 567-569, 602-607 and transport of proteins into

mitchondria, 497-508 in trypanosomes, 651-663, 727-735 turnover, 132, 134-137

Polyamine acetylation, 127-145, 331-340,

Polyamine analogs, and DNA interactions, 517-521 and regulation of polyamine

biosynthesis, 677-690 effects on malaria parasites,

717-725 Polyamine binding,

to liposomes, 481-490 to nucleic acids, 517-524 to phospholipids, 481-490, 525-533 to plant cell surface, 547-558 to plant cell walls, 547-558

Polyamine biosynthesis, post-translational control in

E. coli, 13-24 regulation in mammalian cells, 261-

271 regulation in biosynthetic enzymes,

677-690 inhibitors and plant pathogenesis,

590-598 Polyamine biosynthetic decarboxylases

(PBD) , 365, 378 Polyamine effects,

on adenylate cyclase activity, 535-543

on globin synthesis, 323-326 on malarial DNA synthesis, 643-650 on membrane fusion, 481-490

Polyamine effects (cont'd.) on protein kinase C, 469-480,

481-490 on protein synthesis, 315-330 on ribosomal protein S1, 315-320 on thymidine kinase, 320-323

Polyamine interconversion pathway, 127-145, 346-347

Polyamine metabolism, 147-161, 331, 340

in filarial worms, 737-743 in trypanosomes, 727-731

Polyamine oxidase, biological functions, 148 in filarial worms, 741 in fungi, 582-583 inhibition, 135-136, 140 from maize seedlings, 617, 622 PAO, 128, 135-140 in plants, 550-582 and polyamine interconversion, 128,

135, 138-140 tissue distribution, 148

Polyamine transport, 132, 134-135 in cultured plant cells, 548-553 in filarial worms, 740 in human lymphocytes, 423-426, 509-

515 in isolated protoplast and

vacuoles, 554-557 in sea urchin embryos, 423-426

Polynucleotides, binding of divalent cations, 528

Polypeptide synthesis, messenger-free, 532

Polyphosphoinositides, 481-490 Polyps,

DAO activity in, 749-750 Polysomes,

and ODC mRNA, 245 Post-translational control,

of polyamine biosynthesis in E. coli, 13-24

Post-translational modification, of eIF-4D, 435-447, 459-466 of proteins by polyamines, 391-395 of proteins,

and sea urchin embryos, 428 Post-transcriptional stabilization,

241-252 Pregnancy,

and SAO activity, 147-161 Proenzyme, 74-77

of AdoMet decarboxylase, 105-107 Programmed cell death (see Apoptosis) Promyelocytic leukemia,

and TGase, 395 2-Propenal, 81-89 Propylamine transferase,

genes, 253-260

Propylamine transferase (cont'd.) structures, 253-260

Protein kinase C, activation, 243, 273-290, 469-480,

481-490 Protein-polyamine conjugates, 393-395 Protein synthesis,

polyamine effect on, 313-320, 633-642,

in trypanosomes, 727-735 Protein transport, 497-508 Protozoa,

MTA phosphorylase in, 211-217 Purine analogs, 212, 215-216 Purine nucleoside analogs, 212-215 Putrescine,

in cell differentiation, 291-299 effect on AdoMet-DC synthesis, 103 oxidation in fungi, 582-583, oxidation in plants, 573-582 uptake in plants, 547-558

Putrescine aminopropyltransferase, 111-116

Putrescine N-acetyltransferase, 738-739

Pyrroline, and DAO, 573-582

Pyrroloquinoline quinone (PQQ), and DAO, 574-475

Pyridoxal phosphate, and DAO, 576

Pyruvate, in AdoMet-DC,73-79, 101-109 mechanism of generation in SAMDC,

82, 85

Rat hepatoma, and fluorinated polyamines, 691-706

Rat kidney ODC, 4 Rat pancreas, 379-387 Rat seminal vesicle protein IV

(SV-IV), 403-409 Rat uterus,

estrogenic control of SAT activity in, 345-351

Retinoic acid, effect on tissue TGase, 397-399

Retinoid, and tissue TGase, 398-399

Ribosomal proteins, and ODC antizyme, 13-24

Ribosomal protein Sl, polyamine effect on, 315-320

Ribosomes, binding of tRNA, 529, 537

S-180 cells, 211-213 SAM-DC (see S-Adenosyl-L-methionine

decarboxylase) SAO (see Serum amine oxidase)

717

SAR (see Spennidine/spennine NL acetyltransferase)

SAT (see AcetylCoA:spennidine/ spennine N1-acetyltrasferase)

Sea urchin embryos, 423-434 Seminal vesicle protein IV (SV-IV),

403-409 Senescence,

and transglutaminase, 399 Serum amine oxidase (SAO),

biological functions, 147-161 Signet-ring cell carcinoma, 747 Sim-nor-spennidine, 92-94 Sin-nor-spennine, 92-94 Somatic embryogenesis,

of plants, and polyamines, 567-569, 602-607

spe2, and AdoMet-DC expression, 76-77

speD, gene and spennidine synthase, 76

speE, gene and AdoMet-DC, 74

Spermidine, acetyl transferase , 335-339 analogs, 677-690, 691-706 in cell differentiation, 291-300 effect on AdoMet-DC content, 104 effect on AdoMet-DC expression, 76 effect on OCT transport into mito-

chondria, 497-508 in erythrocytes, 353-363 in hypusine biosynthesis, 435-447,

449-458 -induced modification of ODC,

63-70 levels in trypanosomatids, 670 oxidation in fungi, 582-583 oxidation in plants, 580-582 uptake,

in plant protoplasts, 554-557 Spennidine synthase, 119-126

antibody production, 119-122 mechanism of reaction, 111-117 purification and properties from

mammals, 117-122 Spennine,

analogs, 677-690, 691-706, effect on adenylate cyclase,

535-543 effect on AdoMet-DC synthesis,

101-109 effect on protein kinase C binding

to liposomes, 469-480 effect on calcium binding to lipo­

somes, 481-490 effect on OCT transport into mito­

chondria, 497-508 effect of polyamine metabolism of

filarial worms, 737-743

778

Spennine (cont'd.) effect on tRNA, 525-533 effect on tRNA-ribosome interac-

tions, 525-533 efflux, 491-496 in erythrocytes, 353-363 influx, 491-496 in human cancer cells, 331-344 oxidation in plants, 573-587

Spennine synthase, antibody production, 119-133 inhibition, 691-706 inhibition by fluorinated

spennidine analogs, 696-698 purification and structure, 117-126 transport, 481-490

6-Spennyne, effect on polyamine biosynthetic

enzymes, 677-690 Spongifonn degeneration, 365-378 Steroid hormone action, 1-11 Subacute combined degeneration (Sen),

365-378 Sulfolobus acidocaldarius,

and unusual polyamines, 633-642 Sulfolobus solfataricus,

AdoMet-DC, 91-100 SV-IV (see Seminal vesicle protein IV)

Teratocarcinoma stem cell, differentiation, 291, 296

Testosterone, and ODC, 1-11

12-0-Tetradecanoylphorbol-13-acetate (TPA) , 273-290

Tetrakis(3-aminopropyl)ammonium, in thennophiles, 633-642

Thennine, in thermophiles, 633-642

Thennophilic enzymes, 91-100 Thennus thermophilus, in thermophiles, 633-642 Thioredoxin,

and ODC, 49 Thymidine kinase,

polyamine effect on, 320-333 Tissue transglutaminase,

activity in mouse, 396-397 Tin of DNA,

and polyamines, 633-642 Tobacco cell culture,

and inhibition of polayamine bio­synthesis, 561-566

TPA (see 12-0-Tetradecanoylphorbol-13-acetate)

Transfer RNA (tRNA), aminoacylation of, 528 binding of spennine and divalent

cations to, 528

tRNA (cont' d. ) conformation, stabilization by

spermine, 525-528 ribosome binding, 529-530

Transglutaminase ('mase) , in rat seminal vesicles, 403-409 in Chinese hamster ovary cells

(CHO), 396-397 and growth and differentiation,

398-399 in human epidermal cell envelopes,

417-420 and polyamines, 391-401, 756

Transport, of ODC precursor, 497-508 of polyamines, 677-690

in human lymphocytes, 423-426, 509-515

in plants, 547-558 Tris(3-aminopropyl)amine,

in thermophiles, 633-642 Trypanosoma b. brucei, 211-217,

653-663 and DFMA treatment, 728-731

Trypanosoma cruzi, 211-217, and DFMA treatment, 728-731

Trypanosomes, and ODC activity, 727-735 and trypanothione, 667-672

Trypanosomiasis, effect of DFMO, 653-663

Trypanothione, regulator of spermidine levels in

trypanosomes, 667-672 Trypsin inhibitor, 379-387, 755 Tumor induction, 745-752 TlmIor promoter,

and ODC induction, 273-290 Turnover,

of ODC, 45-53

Uptake, of polyamines,

by human lymphocytes, 423-426, 509-515

by sea urchin embryos, 423-424, 426

Vanadate, and polyamine uptake, 512-514

Xylosyl-MTA (see 9-[5'-Deoxy-5' (methylthio)a-D-xylofurano­syl]adenine)

lea mays, PADs in, 617-622

779