LIST OF PARTICIPANTS

Alexander Alexandrov Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Henry Arnstein Dept. of Biochemistry University of London King's College Strand, London WC2R 2LS United Kingdom

Hans-Jochen Bartels Mathematical Institute University of Gottingen Bunsenstrasse 3/5 34 Gottingen BRD

D. Bellamy Department of Zoology University College Cardiff United Kingdom

Melvin Blecher Department of Biochemistry Georgetown University

Medical Center Washington, D.C. 20007 USA

Monique Boumokra Societe Internationale de

Biologie Mathematique 11 bis avo de la Providence 92-Antony France

451

Francis Collot Societe Internationale de

Biologie Mathematique 11 bis avo de la Providence 92-Antony France

Dimiter Dimitrov Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Vladimir Dimov Institute of Animal Science Kostinbrod Bulgaria

James A. Edwardson Imperial College of Science

and Technology Department of Biochemistry London SW United Kingdom

Elka Elenkova Central Lab. of Biophysics Bulgarian Academy of Sciences 1113 Sofia Bulgaria

Olga D. Genbacev-Krtolica Institute for the Application

of Nuclear Energy in Veterinary Agriculture

Zemun Yugoslavia

452

Georgi Georgiev Central Lab. of Bulgarian Acad. 1113 Sofia Bulgaria

Biophysics of Sciences

Denis Gospodarowicz The Salk Institute for

Biological Studies San Diego, California USA

Gopal Saran Gupta Dept. of Biophysics Panjab University Chandigarh-160014 India

Nadejda Hadjivanova Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Michel Hall University of Southampton Highfield Southampton United Kingdom

Nikola Ivanov Medical Institute of Varna Marin Drinov St. 55 Varna Bulgaria

Elwood Jensen University of Chicago 950 East 59th St. Chicago, Illinois USA

LIST OF PARTICIPANTS

Dobrina Kalitzin Medical Institute of Varna Chair of Biochemistry Marin Drinov St. 55 Varna Bulgaria

Georgy Kichev Institute of Biology and

Pathology of Reproduction 73 Lenin Ave. 1113 Sofia Bulgaria

Nikolai Koralov Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Marin Kotarov Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Stefan Kovachev Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Pavel Kulev Central Lab. of Biomech. Bulgarian Acad. of Sciences 7 November St. Sofia Bulgaria

Kamen Kumanov Institute of Animal Science Kostinbrod Bulgaria

Ivan Madjarov Institute of Animal Science Kostinbrod Bulgaria

LIST OF PARTICIPANTS

Alina Maleeva Institute of Endocrinology Medical Academy Boul. Chr. Michailov 6 Sofia Bulgaria

Dieter Maretzki Institute of Biochemistry Humbolt-Universitat Hessische St. 3/4 104 Berlin GDR

Kaltscho Markov Center for Biology Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Marko Markov Biological Faculty Sofia University Moskowska St. 49 Sofia Bulgaria

Stefan Milanov Institute of Endocrinology Medical Academy Boul. Chr. Michailov 6 Sofia Bulgaria

Ina Mindova Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Vassil Neitchev Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

453

Tania Neitcheva Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Robert Northcutt Mayo Clinic Division of Endocrinology Rochester, Minnesota USA

Doitchin Panayotov Institute of Endocrinology Medical Academy Boul Chr. Michailov 6 Sofia Bulgaria

Zlatko Penev Medical Institute of VaMla Marin Drinov St. 55 Varna Bulgaria

Temenuzhka Pentcheva Medical Institute of Varna Marin Drinov St. 55 Varna Bulgaria

Alexander Petrov Institute of Solid State

Physics Bulgarian Acad. of Sciences Boul. Lenin 72 Sofia Bulgaria

Igor Politaev Institute of Molecular

Biology Academy of Sciences Vavilova St. 32 Moscow USSR

454

Vladimir Prokopov Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Michail Protich Institute of Endocrinology Medical Academy Boul. Chr. Michailov 6 Sofia Bulgaria

Robert Rees Genetics Department Aberdeen University 2 Tillydrone Ave. Aberdeen United Kingdom

Karl-Ernst Reinert Institute of Microbiology

and Experi~ental Therapy Academy of Sciences of GDR Beutenberg St. 11 Jena GDR

Jean Richard Societe Internationale de

Biologie Mathematique 30 rue des Binelles 92 Serves France

Brij Saxena Cornell University Medical College 1300 York Avenue New York, N.Y. USA

WOlfgang Schulze Central Institute of Heart

and Circulatory Regulation Research

Academy of Science of GDR Lindenberger Weg 70 1115 Berlin Buch GDR

LIST OF PARTICIPANTS

Milka Setchenska Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Radoslav Simeonov Institute of Micr0elements Boul. Lenin 72 Sofia Bulgaria

Ralitza Staikova Central Lab. of Biochemistry Faculty of Medicine Plovdiv Bulgaria

Maria Staub 1st Institute of Biochemistry Semmelweis University Medi-

cal School VIII Pecskin u. 9 Budapest Hungary

Anton Stoimenov Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Bayard Storey Dept. of Obstetrics and

Gynecology Univ. of Pennsylvania

School of Medicine Philadelphia, PA 19174 USA

V. Sud Dept. of Biophysics All-India Institute of

Medical Sciences New Delhi-l10016 India

LIST OF PARTICIPANTS

Gospodin Sveshtarov Center for Biology Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Ah Ti Tan Faculty of Medicine McGill University 3655 Drummond St. Montreal Canada

Jamshed Tata . National Institute for

Medical Research Mill Hill London NW7 lAA United Kingdom

Dintcho Traikov Repub. Hospital Boris I St. Sofia Bulgaria

Penka Tsocheva-Mitseva Central Lab. of Biophysics Bulgarian Acad. of Science 1113 Sofia Bulgaria

Yacov Varshavsky Academy of Sciences of the

USSR Institute of Molecular

Biology Vavilov St. 32 Moscow B-312 USSR

455

Nicola Vassilev Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Julia Vassileva-Popova Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

Nelli Visheva Institute of Endocrinology Medical Academy Boul. Chr. Michailov 6 Sofia Bulgaria

Viktor Vransky Agricultural Academy Boul. Dragan Zankov 8 Sofia Bulgaria

Tony Yaney Central Lab. of Biophysics Bulgarian Acad. of Sciences 1113 Sofia Bulgaria

W. Zainzinger Beckman Instruments Austria Stefan-Esders-Platz 4 A-1191 Vienna Austria

SUBJECT INDEX

Abortion, HPL in, 147 ACTH (adrenocorticotropic hor­

mone), 13, 19, 264, 355, 356

Adenohypophasjs, 361-67, 391 Adenosine triphosphate (see

ATP) -Adrenaline, 265-66 (see also

Epinephrine) Adrenocortical hormones, 264,

355-56, 401 Aging (ageing)

adaptation in, 66 adrenocortical hormones in,

355-56 central nervous system (CNS)

in, 63, 66-68 hormone dysfunction in, 351 hormone regulation in, 63-88,

354";55 hypothalmus in, 254 information transfer in, 63-88 process of, 349-51 sex steroids effects in, 68-82 stress response in, 356=57

Alcoholism, testicular efficien­cy and, 371-76

Allosteric interactions, confor­mational changes and, 127-35

Amino acids in age changes, 65-67 in protein synthesis, 272-73

Anemia, blood cell synthesis in, 285-89, 291-95

Antibody-antigen reactions, 13-19

ATP (adenosine triphosphate) activity in sperm, 299 effects of gonadotropic hor­

mones on, 160 Autoimmunity, 356

Binding, of chorionic gonado-tropin (hCG)

457

and free mobile cells, 203"';08 to luteal cells, 177-197 of protein hormones, 203"';08

Biochemical research, equipment and technology, 341-45

Bioelectric brain activity, sex hormones and, 385-88

Biomembranes elasticity of, 113-14 flexoelectric effects on,

112-23 liquid crystalline structure,

111-12

458

Biopolymer molecules informational transfer acti­

vities of, 99-109 investigational perspectives,

141-42 Biotons, 3, 4, 9 Blood flow, magnetic field ef­

fects on, 427-40 Blood sugar levels, and age, 352 Bone marrow, erythroid cell

development, 285-89

Caffein, effects on lung trigly­ceride lipases, 423

Calcium ion activity, in cell respiration, 297-304

Cardiovascular system, aging manifestations in, 68

Catecholamine hormones, 391-92 (see also Epinephrine)

Cells binding of IhCG to different

types, 188 blood, 203-08, 285-89 deep freezing of, 377-83 enzyme role in division of,

287-89 erythroid, 285-89 free moving, 203-08, 391-96 proliferation of, factors ef-

fecting, 297-99, 371~76, 406

see Sperm cells stimulation of growth, 273-75

Central regulatory proteins(CRP), 4j-51, 53-55, 63

Centrifuges, 342-43 Chemical mass action, substrate

concentration and, 53-62 Chorionic gonadotropin (CG),

binding of, 177-97 Chromatin, 65, 267 Collagen, 356, 401, 404 Control systems, for development

in time, 35-41 Cortisol, 401-06

Corticosteroids in aging research, 68 autoimmunity and, 356

INDEX

thymus changes due to, 401-03 Cyclical AMP (anedosine mono­

phosphate), 297-304 Cyclical recurrence, in hormone

regulation, 43-50 Cystol, estradiol-receptor trans­

formation in, 211-23 DHTbinding and, 232, 234

Cytoplasm growth response in target,

276-78 protein synthesis in, 270-76

Dehydroepiandrosterone (DHEA), inhibitory effects of, 279-83

Deuterium-hydrogen exchange, 100-07

alpha-Dihydrotestosterone (DHT), target receptor response of,

231-34 Diabetes mellitus, testicular

efficiency in, 371-76 DNA (deoxyribonucleic acid)

estrogen effects on, 239-41 informational role of, 99,

109 synthesis, 267, 286, 297-99,

371-76, 406, 409-17 DNA polymerase, 409-17

Ecdysone, 265, 266, 272 ECG (electrocardiogram), data

transmission, 335-39 EEG (electroencephalogram),

changes in due to sex hormones, 385-88

Embryoactive substances (onto-genins), 307 -08

Endocrinology, of aging, 68 Energetic effiCiency, calcula­

tions of, 4-7 Energy conversion, molecular,

137-38, 142

INDEX

Environment, as hormonal stimu­lus, 261-64

Enzymes in aging, 65-66 in blood cell differentiation,

285-89 gonadotropic hormone effects,

161 in piezoelectric effects in

hormones, 141 proteolytic, 177, 197 substrate interactions with,

53-61, 83-84, 103 Epididymal sp.erm, 297-304 Epinephrine (adrenaline)

adenohyphasis and, 391 free moving cells and, 391-96 lung triglyceride lipases and,

419-25 response to, 265-66 sperm cells and, 391-96

Erythroblasts, 285-89, 291-95 Erythrocytes, magnetic field

effects on, 446 Erythropoiesis, 267, 285-89, 355 Estriadol-receptor complex,

transformations, 211-20 Estrogen, 266, 272 (see also Sex

steroids) --- ----in cytoplasmic protein synthe­

sis, 272-3 nuclei target cell responses

to, 271 synthetic, in protein synthe­

sis, 237-48 target receptor transformation

and, 211-23

Flexoelectric polarization in biomembranes, 111-23 cybernetic model of, 122

459

and piezoelectric effects,142 Fluctuation equilibrium, in con­

formational changes, 127, 130-33

Fluid mosaic model, 103, 201 Follicle stimulating hormone

(FSH) , 187-97, 203-07, 231

Free mobile cells, protein hor­mone binding to, 203-08

Glycoproteins, 83, 377-78 Gonadotropic hormones, 157-62 Growth hormones, 265, 267, 273-

278 Growth of organic bodies, calcu­

lations for, 3-11

Hapten-antibody reaction, 13 Heavy water, 100-07 Hemoglobin

conformational changes 106-09

in,

infra-red spectroscopy, 106 magnetic field effects, 446 production of, 285-88

Heterotropic effect, formula for, 76-77

Histone, 267, 288 Homotropic effect, formula for,

testosterone conversion to, Estrophilin

231 75

isolation and purification, 220-23

transformation of,211-33 External electric fields, in

membranes, 117-23

Hormonal activity, target recep­tor response, 82-88

Hormonal-antibody reactions, al­losteric model, 13-19

bio- Hormonal concentration, periodic regulation and, 82

Hormonal metabolism, 21-33 Hormonal receptor complex, model

Feminization, testicular, 229-34 of, 23 Flashing-light spectroscopy, 313- Hormonal receptors (~ Target

332 receptors) Flexoeffect, 123

460

Hormonal regulation in aging, 63-88, 349-58 cyclical recurrence of, 45-50 of growth, mathematical as-

pects, 3-11 processes of, 82-88, 261-78

Hormone-hormone complex forma­tion, 251-55

Hormones (see also specific ~and~)

evolutionary position of, 263 growth and deve10pmerlt func­

tions, 263-69 informational transfer func­

tions, 261-62 protein synthesis stimulation,

275-78 releasing (RH), 49-51

Hormone substrates, characteris­tics, 83-84

Human placental lactogen (HPL), synthesis of, 147-55

Hydrogen isotope exchange, 100-6 Hydrophobic interaction of pro­

tein and steroid hormones, 254-55, 281

Hyperplasia, 361-67 Hypothalmic-pituitary-adrena1

axis, 354-58 Hypothalmic release hormones,

264

Information transfer in aging processes, 64-88 by biopolymer conformation

changes, 99-109 chemical, 229, 234 by DNA molecules, 99, 109 in embryos, 307-308 hormonal functions in, 261-64 in thymus regeneration, 407-07 types of processes, 99-100

Insulin, 201-02, 265-66 effects on lung triglyceride

1ipases, 419-25 secretion of, and age, 352

Interstita1 cell stimulating hor­mone (ICSH), 63, 70-71

INDEX

d-Irradiation, gonadal effects from, 361-67

Islets of Langerhans, 352 Isoenzyme inhibition, 279-83

Lactogen, human placental (HPL), synthesis of, 147-55

Lecithin molecule, 114, 116 Leucocytes, magnetic field ef­

fects on, 446 Life span, 350-51 Lipid molecules, structural

properties, 112-19 Liquid crystals, structural

properties, 112-17, 123 Luteal cells and membranes,

heG binding of, 179-99 Luteinizing hormone (LH) , 45-

48, 178-97, 231, 252 Luteotropic hormone (LTH), 203,

207 Lymphocytes, 401-06

DNA synthesis in, 409-17 in thymus grafts, 406

Lysosomes, 288, 355

Magnetic field, physiological effects of, 441-49

Magnetic field strength, and fluid flow pressure, 427-40

Magnetohydrodynamics (MHD), 427-40

''Magnetic'' water, physiological effects, 441-49

Mass action, law of, in sub­strate concentration, 53-62

Membrane changes, in aging, 66 Metabolic changes, hormone reg­

ulation of, 264, 275-78 Mitochondria, Calcium ion up­

take by, 297-303 Mitosis, estrogen effects on,

237

INDEX

Neurotransmitters, 67, 86-87, 261 Nucleic acid

in aging research, 65-66 conformational transitions of,

103, 109 in informational transfer,

100, 103 synthesis of, 237-48, 287

Nucleus, cellular genetic transcription and, 268 growth response in, 276-78

Ontogenines, embryoactive sub­stances, 307-08

Organic body growth, calculations of, 3-11

Oscillation in regulatory hor­mones, 43-51.

Oxytocin effect, in hormone re­ceptor theory, 21-33

Parathyroid hormone, 266 Peptide NH groups, 100-07 Periodicity, in hormonal regula-

tion, 43-51, 82 Pheromones, 261 Piezoelectric effect (PEE)

anisitropic coefficient of, 138 in biomembranes, 113-14, 119 see also Flexoelectric polar­-- ization in protein crystals, 137-142

Pituitary, anterior (see Adeno­hypophasis)

Pituitary tissue, prolactin in, 169-75

Placental proteins, synthesis of, 147-55

Plasma membrane (PM), liver, 201 luteal, 179, 187, 192, 196

Polypeptides, 101-03, 201-02 Prednisone, 355 Prolactin (Pr)

binding to blood and sperm cells, 203-06

blood serum and pituitary concentrations, 169-75

in hormone-hormone interac­tion, 252

461

in male reproductive function, 174

Prostoglandin (PGF-2 alpha), in placental protein synthe­sis, 147-55

Protein conformation allosteric site changes,

127-34 in biopolymer molecules, 102-

108 in hormone-hormone interac­

tion, 251-55 Protein globules (crystals)

active transport mechanism, 116-17

external electric field, 119-21

flexoelectric orientation, 117 hydrogen isotope exchange in,

103-05 piezoelectric effect in, 137-

142 Protein hormones (PH)

in age changes, 63-87 binding in blood and sperm

cells, 203-08 cyclical regulation in, 43-51 in sex steroid interaction,

75-80, 251-55 substrate effects in, 53-61

Protein synthesis amino acids in, 272-73 by bone marrow cells, 286-87 in cytoplasm, 272-73 hormonal regulation of, 265-66 placental, 147-55 ribosome stimulation and, 273-

278 synthetic estrogen effects

on, 237-48

Receptors (see Target receptors)

462

Releasing hormones (RR), 49-51 Reticulocytes, 292, 294 Ribosomes

hormone stimulated prolifera­tion of, 273-75

in protein synthesis, 246-47, 270-71, 286

RNA (ribonucleic acid) blood cell content in anemia,

291-95 concentration effected by syn-

thetic estrogen, 239-48 messenger (mRNA), 269-72, 288 see RNA-polymerase ribosomal (rRNA), 270-71, 286 see RNA synthesis transcriptional control, 267-

268 RNA-polymerase

in genetic transcription, 267-268

informational role of,99 synthesis capability, 216-20

RNA synthesis in bone marrow cells, 296-98 estrogen effects on, 238 hormonal stimulation of, 273-

278, 285-89 see also Protein synthesis ribosomes in, 272-73

Secretin, 201-02 Semen, deep free~ing of, 377-83 Seminal plasma glycoproteins,

377-83 . Sex character information, 229-

234 Sex factor, in prolactin con­

tent, 169-75 Sex steroids (55)

in age regulation, 68-80 EEG responses to, 385-88 ~ also Estrogen in hormone-hormone interaction,

251-55 inhibitory effects of, 75, 80,

81, 279

INDEX

protein hormone interaction, 75-80, 251-255

substrate concentration and, 53-61

target receptor interactions, Sexual disorders, and spermato­

genesis, 371-76 Spermatogenic activity test

(SAT), 371-76 Spermatogenesis, factors effec­

ting, 371-76 Sperm cells, human, 203-08

in epididymis, 297-304 epinephrine effects on, 391-

397 Sperm dilution, 377-83 Substrate

binding on tetramer enzymes, 129

concentration and mass ac­tion, 53-62

enzyme interaction, 83-84, 103

Target receptors (TR) in age change regulation, 63-

74, 83, 86-87 central signal and, 82 chorionic gonadotropin bind-

ing and, 187, 192 of epinephrine, 392-93 estrogen effects on, 211-23 hepatic, 201-02 hormonal activation of, 82-

86, 285 prote:i.n hormone i.nteraction

in, 75, 78-·80 protein synthesis simulation

in, 275-·78 in recurrent hormonal regula-·

t:i.on, 45-51 site affinity modulation, in

luteal cells, 177, 196 substrate effects on, 13-61

Template activity, hormonal regulation of, 267

Testicular biogenic activity, 157-62

INDEX

Testicular feminization, 229-34 Testicular function efficiency,

361-67, 371--76 Testosterone, 229-34 Thymus

corticosteroid effects on, 401--03

graft implants of, 401-07 hormones and age changes, 69 regeneration, 406

Thyreo-stimu1ating hormone (TSH), 163-67, 178, 264

Thyroid functions, 351-52 Thyroid gland, hormone effects

on, 264 Thyroxine, 266 Tonsillar lymphocytes, DNA syn·­

thesis tn, 409-17 Transcription, gEmettc, 267-68,

270-72

463

Translation control, in RNA syn­thesis, 268-69, 272-73

Tryptophane (Trp), in hormone­hormone interaction, 251-255

Vagus, cervical, EEG response to sex stimuli, 385-88

Vascular systems, magnetic field effects on, 427-40

Vasoactive intestinal polypep­tide (VIP), 201-02

Vasopressin, 266 Vite110genin, 272

Water, magnetic field effects and, 441-49