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Lorena C. Guerrero, PhD, MN, ARNP, FNP-BCAssistant Professor School of NursingPacific Lutheran UniversityTacoma, WA

Anne Hedger, DNP, ACNP-CS, ANP-CS, CPNP-AC, ENP-BC, CCRNAssociate Clinical ProfessorAcute Care Curriculum Coordinator/AGACNP ProgramSchool of NursingBoise State UniversityBoise, ID

Leila N. Jones, MSN, BA, RNMadison House—Genesis Healthcare Madison, CT

Jennifer Jordan, RPh, PharmD, BCPSAssociate ProfessorSchool of Pharmacy Pacific UniversityHillsboro, OR

Tracy Klein, PhD, FNP, ARNP, FAANP, FRE,FAANAssistant Professor, College of NursingWashington State University, VancouverVancouver, WA

Ashim Malhotra, BPharm, PhDAssistant Professor School of Pharmacy Pacific UniversityHillsboro, OR

Theresa Mallick-Searle, MS, RN-BC, ANP-BCDivision of Pain MedicineStanford Health CareRedwood City, CA

Erin Anderson, MSN, CPNP Pediatric UrologyOregon Health & Science University Portland, OR

Cally Bartley, MSN, FNP-CInstructorSchool of Medicine, Department of Dermatology University of Colorado Anschutz Medical CampusAurora, CO

Jane M. Carrington, PhD, RNAssistant ProfessorCollege of NursingUniversity of ArizonaTucson, AZ

Diana L. Dewell, ARNP, ANPFamily Medicine ClinicMadigan Healthcare System Fort Lewis, WA

Gina Dobbs, MSN, CRNPNurse Practitioner and Sub-Investigator1917 HIV/AIDS Outpatient/Research ClinicUniversity of Alabama at BirminghamBirmingham, AL

Krista Estes, DNP, FNP-CAssistant Professor College of NursingUniversity of Colorado Anschutz Medical CampusAurora, CO

Teral Gerlt, MS, RN, WHCNP-EInstructorSchool of NursingOregon Health & Science University Portland, OR

Theresa Granger, PhD, ARNP, FNP Visiting Professor Chamberlain College of NursingDowners Grove, IL

CONTRIBUTORS

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Fujio McPherson, RN, DAOM, MSN, FNP, LAC Internal Medicine Clinic Madigan Army Medical Center Fort Lewis, WA

Benjamin J. Miller, PhD, MN, ARNP, FNP, ACNPAssistant ProfessorCollege of NursingSeattle University Seattle, WA

Anne E. Morgan, PharmDClinical Pharmacy Specialist, Department of NeurologyUniversity of Colorado HospitalAurora, CO

Joan Nelson, DNP, RNAssociate Professor College of NursingUniversity of Colorado Anschutz Medical CampusAurora, CO

Patricia Nodine PhD, CNMAssistant ProfessorCollege of NursingUniversity of Colorado Anschutz Medical CampusAurora, CO

Kristen Lambert Osborn, MSN, CPNP–AC/PCPediatric Nurse PractitionerUAB Division of Pediatric Hematology and OncologyChildren’s of AlabamaBirmingham, AL

James L. Raper, DSN, CRNP, JD, FAANP, FAANHIV/AIDS Outpatient, Research and Dental ClinicAssociate Professor of Medicine & NursingUniversity of Alabama at BirminghamBirmingham, AL

Peter J. Rice, PharmD, PhD, BCPS ProfessorSkaggs School of Pharmacy and Pharmaceutical SciencesUniversity of Colorado Anschutz Medical Campus Aurora, CO

Laura Rosenthal, DNP, ACNPAssistant ProfessorCollege of NursingUniversity of Colorado Anschutz Medical CampusAurora, CO

Ruth Schaffler, PhD, FNP Emeriti Associate Professor School of Nursing Pacific Lutheran University Tacoma, WA

Tracy Scott, DNP, FNPAssistant Professor Department of Family MedicineSchool of MedicineUniversity of Colorado Anschutz Medical CampusAurora, CO

Kathy Shaw, DNP, RN, CDEAssistant ProfessorCollege of NursingUniversity of Colorado Anschutz Medical CampusAurora, CO

R. Brigg Turner, PharmD, BCPSAssistant ProfessorSchool of Pharmacy Pacific UniversityHillsboro, OR

Connie Valdez, PharmD, MSEd, BCPSAssociate Professor, Department of Clinical PharmacySkaggs School of Pharmacy and Pharmaceutical SciencesUniversity of Colorado Anschutz Medical Campus Aurora, CO

Mary Weber, PhD, PMHNP-BC, FAANP Associate Professor College of Nursing University of Colorado Anschutz Medical Campus Aurora, CO

xiv • Contributors

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xv

Joan Parker Frizzell, PhD, CRNP, ANP-BCAssociate ProfessorSchool of Nursing & Health SciencesLa Salle University Philadelphia, PA

Tammy Gilliam, DNP, APRN-BC, FNPAssistant Professor of Nursing/Adjunct FacultyUniversity of South Carolina/USC UpstateSpartanburg, SC

Cathy R. Kessenich, DSN, ARNP, FAANPProfessor of Nursing, MSN Program DirectorUniversity of TampaTampa, FL

Pamela King, PhD, APRN, FNP, PNPMSN Program DirectorSpalding UniversityLouisville, KY

Angela I. Kulesza, DNP, NP-CAssistant Professor School of Nursing, Science and Health

ProfessionsRegis CollegeWeston, MA

Christine Nelson-Tuttle, DNS, RN, PNP-BCAssociate Professor, Undergraduate ChairSt. John Fisher CollegeRochester, NY

David G. O’Dell, DNP, ARPN, FNP-BCGraduate Nursing Program DirectorSouth UniversityRoyal Palm Beach, FL

JoAnne Pearce, MS, PhDc, RN, APRNDirector of Nursing ProgramsIdaho State University, College of TechnologyPocatello, ID

Marianne Adam, PhD, RN, CRNPAssistant ProfessorMoravian CollegeBethlehem, PA

Nancy Beckham, PhD, FNP-CAssociate ProfessorGonzaga UniversitySpokane, WA

Christopher W. Blackwell, PhD, ARNP, ANP-BC,AGACNP-BC, CNEAssociate ProfessorCollege of NursingUniversity of Central FloridaOrlando, FL

Sharon Chalmers, PhD, CNE, APRN-BCAssociate ProfessorUniversity of North GeorgiaDahlonega, GA

Patsy E. Crihfield, DNP, APRN, FNP-BC,PMHNP-BC, PMHSChair of Nurse Practitioner Tracks, Graduate ProgramUnion UniversityGermantown, TN

Linda Dayer-Berenson, PhD, MSN, CRNP, CNE,FAANPAssociate Clinical ProfessorDrexel University–CNHPPhiladelphia, PA

Carolynn A. DeSandre, PhD, CNM, FNP-BCAssistant ProfessorUniversity of North GeorgiaDahlonega, GA

Abimbola Farinde, PharmD, MSClinical Pharmacist SpecialistWebster, TX

REVIEWERS

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Julie Ponto, PhD, RN, ACNS-BC, AOCNSProfessorWinona State University–RochesterRochester, MN

Susan Quisenberry, DNP, APRN, CNP, FNP-CAssistant ProfessorUniversity of Oklahoma College of NursingOklahoma City, OK

Sandra Restaino, DNP, NP-C, FAANP, CSCNurse Practitioner and Assistant ProfessorEastern Michigan UniversityYpsilanti, MI

Maria Rosen, PhD, RN, PNP-BCInterim Director of Graduate Nursing ProgramsMassachusetts College of Pharmacy and Health SciencesWorcester, MA

Kathleen R. Sheikh, MSN, FNP-BCAssistant ProfessorMisericordia UniversityDallas, PA

Jennifer Sipe, RN, MSN, APRN-BCAssistant ProfessorLa Salle UniversityPhiladelphia, PA

Angela Thompson, PhD, PharmDNursing InstructorUniversity of North DakotaValley City, ND

Diane Yorke, MSN, MBA, PhD, RN, CPNPClinical Assistant Professor (Adjunct)University of North Carolina Chapel Hill School of NursingChapel Hill, NC

xvi • Reviewers

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Chapter 16 Drugs Affecting the Cardiovascular and Renal Systems 295Marylou V. Robinson, PhD, FNP-C

Chapter 17 Drugs Affecting the Respiratory System 361Teri Moser Woo, PhD, CPNP

Chapter 18 Drugs Affecting the Hematopoietic System 415Teri Moser Woo, PhD, CPNP and Kristen Lambert Osborne MSN, CPNP AC/PC

Chapter 19 Drugs Affecting the Immune System 447Teri Moser Woo, PhD, CPNP

Chapter 20 Drugs Affecting the Gastrointestinal System 497Teri Moser Woo, PhD, CPNP

Chapter 21 Drugs Affecting the Endocrine System 541Marylou Robinson, PhD, FNP and Kathy Shaw, DNP, RN, CDE

Chapter 22 Drugs Affecting the Reproductive System 615Diana L. Dewel, ARNP, ANP

Chapter 23 Drugs Affecting the Integumentary System 647Cally Bartley, MSN, FNP-C

Chapter 24 Drugs Used in Treating InfectiousDiseases 691Jennifer Jordan, RPh, PharmD, BCPS; R. Brigg Turner, PharmD, BCPS; and Teri Moser Woo, PhD, CPNP

Chapter 25 Drugs Used in Treating Inflammatory Processes 801Teri Moser Woo, PhD, CPNP

Chapter 26 Drugs Used in Treating Eye and Ear Disorders 837Teri Moser Woo, PhD, CPNP

UNIT III. PHARMACOTHERAPEUTICS WITH MULTIPLE DRUGS 863

Chapter 27 Anemia 865Teri Moser Woo, PhD, CPNP and Kristen Osborn MSN, CPNP AC/PC

Chapter 28 Chronic Stable Angina and Low-Risk Unstable Angina 881Laura D. Rosenthal, DNP, ACNP

Chapter 29 Anxiety and Depression 897Mary Weber, PhD, PMHNP-BC, FAANP and Krista Estes, DNP, FNP-C

UNIT I. THE FOUNDATION 1

Chapter 1 The Role of the Nurse Practitioner as Prescriber 3Teri Moser Woo, PhD, CPNP and Marylou V. Robinson, PhD, FNP-C

Chapter 2 Review of Basic Principles of Pharmacology 11Peter J. Rice, PharmD, PhD, BCPS

Chapter 3 Rational Drug Selection 29Teri Moser Woo, PhD, CPNP

Chapter 4 Legal and Professional Issues inPrescribing 37Tracy Klein, PhD, FNP

Chapter 5 Adverse Drug Reactions 51Connie A. Valdez, PharmD, MSEd, BCPS; Anne E. Morgan, PharmD; and Peter J. Rice, PharmD, PhD, BCPS

Chapter 6 Factors That Foster Positive Outcomes 61Marylou V. Robinson, PhD, FNP-C and Teri Moser Woo, PhD, CPNP

Chapter 7 Cultural and Ethnic Influences inPharmacotherapeutics 75Lorena C. Guerrero, PhD, MS, ARNP, FNP-BC andLeila M. Jones, RN, MSN

Chapter 8 An Introduction to Pharmacogenomics 103Ashim Malhotra, BPharm, PhD

Chapter 9 Nutrition and Neutraceuticals 115Teri Moser Woo, PhD, CPNP

Chapter 10 Herbal Therapy and NutritionalSupplements 129Fujio McPherson, RN, DAOM, MSN, FNP, LAC

Chapter 11 Information Technology andPharmacotherapeutics 151Jane M. Carrington, PhD, RN

Chapter 12 Pharmacoeconomics 159Teri Moser Woo, PhD, CPNP

Chapter 13 Over-the-Counter Medications 165Teri Moser Woo, PhD, CPNP

UNIT II. PHARMACOTHERAPEUTICS WITH SINGLE DRUGS 171

Chapter 14 Drugs Affecting the Autonomic Nervous System 173Tracy Scott, DNP, FNP

Chapter 15 Drugs Affecting the Central Nervous System 225Teri Moser Woo, PhD, CPNP

CONTENTS

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Chapter 30 Asthma and Chronic ObstructivePulmonary Disease 913Benjamin J. Miller, PhD, MN, ARNP, FNP, ACNP

Chapter 31 Contraception 943Teri Gerlt, MS, RN, WCHNP

Chapter 32 Dermatological Conditions 957Teri Moser Woo, PhD, CPNP

Chapter 33 Diabetes Mellitus 991Kathy Shaw, DNP, RN, CDE and Marylou Robinson, PhD, FNP-C

Chapter 34 Gastroesophageal Reflux and Peptic Ulcer Disease 1021Teri Moser Woo, PhD, CPNP

Chapter 35 Headaches 1035Theresa Mallick-Searle, MS, RN-BC, ANP-BC

Chapter 36 Heart Failure 1063Laura Rosenthal, DNP, ACNP

Chapter 37 Human Immunodeficiency Virus Disease and AcquiredImmunodeficiency Syndrome 1081James Raper, DSN, CRNP, JD, FAANP, FAAN andGina Dobbs, MS, CRNP

Chapter 38 Hormone Replacement Therapy and Osteoporosis 1103Marylou V. Robinson, PhD, FNP-C

Chapter 39 Hyperlipidemia 1129Marylou V. Robinson, PhD, FNP-C

Chapter 40 Hypertension 1155Marylou V. Robinson, PhD, FNP-C

Chapter 41 Hyperthyroidism and Hypothyroidism 1179Marylou V. Robinson, PhD, FNP

Chapter 42 Pneumonia 1195Anne Hedger, DNP, ACNP-CS, ANP-CS, CPNP-AC, ENP-BC, CCRN

Chapter 43 Smoking Cessation 1205Benjamin J. Miller, PhD, MN, ARNP, FNP, ACNP

Chapter 44 Sexually Transmitted Diseases and Vaginitis 1217Theresa Granger, PhD, ARNP, FNP

Chapter 45 Tuberculosis 1237Teri Moser Woo, PhD, CPNP

Chapter 46 Upper Respiratory Infections, Otitis Media, and Otitis Externa 1253Teri Moser Woo, PhD, CPNP

Chapter 47 Urinary Tract Infections 1267Erin Anderson, MSN, CPNP

UNIT IV. SPECIAL DRUG TREATMENTCONSIDERATIONS 1281

Chapter 48 Women as Patients 1283Priscilla M. Nodine, PhD, CNM

Chapter 49 Men as Patients 1303James Raper, DNS, CRNP, JD, FAANP, FAAN

Chapter 50 Pediatric Patients 1321Teri Moser Woo, PhD, CPNP

Chapter 51 Geriatric Patients 1337Joan M. Nelson, DNP, RN

Chapter 52 Pain Management: Acute and Chronic Pain 1351Ruth L. Schaffler, PhD, FNP

INDEX 1373

xviii • Contents

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