3-D + Medical Imaging
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Transcript of 3-D + Medical Imaging
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3-D+ Medical Imaging
Neb Duric 3-D ESO workshop June 12, 2008
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Medical ImagingCross-sectional views in the fundamental planes.
Coronal Sagittal
Transverse
Visible Human Project
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Tomographic Imaging
• Common devices– Magnetic Resonance Imaging– X-ray Computed Tomography– Positron Emission Tomography– Ultrasound Tomography
• Common applications– Screening– Diagnosis– Therapy guidance– Treatment monitoring
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Image Cubes
CT Scans of Chest
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Projections of Image Cube
coronal sagittal transverse
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Volume Imaging
Kai Uwe Barthel (k.barthel at fhtw-berlin.de)Internationale MedieninformatikBerlin, Germany
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3D imagingTransparency, Depth Cueing
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Characterization
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3-D + CharacterizationFusion Imaging
Pretreatment 6 h post 24 h post18 d post
Functional Imaging
MRI
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Visualizing Risk
PET/CTFunctional Imaging
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Lung PlaqueSegmentation
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ConfidentialConfidentialAcoustic
Tomography
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The Team
Neb Duric1,2, Ph.D., Peter Littrup1,2, M.D., Cuiping Li1,2, Ph. D., Carri Glide1,2, Ph.D., Lisa Bey-Knight1,2, R.N., Yang Xu1,2, Ph.D., Steve Schmidt1,2, Olsi Rama1,2, Jason Shen1,2, PhD., Anthony Shields, M.D., Ph.D., Ding Wang, M.D., Ph.D., Lou Poulo3, M.Sc., Terry Kling4, Alex Babkin5, Ph.D., Roman Pevzner5, Ph.D., Lianjie
Huang6, Ph.D., Francesco Simonetti7, Ph.D., Ivana Jovanovic8 , Ph.D., Nicole Ruiter9, Ph.D., Frank Natterer10, Ph.D.
1Barbara Ann Karmanos Cancer Institute, Detroit, MI2Wayne State University, Detroit, MI
3Analogic Corp, Boston, MA4Sound Technology, State College, PA5Groupvelocity LLC, Albuquerque, NM
6Los Alamos National Laboratory, Los Alamos, NM7Imperial College, London, England
8Ecole Polytechnique Federale de Lausanne, Switzerland9Forschungszentrum Karlsruhe, Karlsruhe, Germany
10University of Muenster, Muenster, Germany
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Prototype ScannerImaging Tank and Ring Array
In plane resolution: 0.5 – 2 mm Out of plane resolution: 4 mm 2 MHz operating frequency
Duric et al, Medical Physics Vol 34 (2), pp. 773-785, 2007
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Scan Method
Reflection Sound Speed Attenuation
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Thresholding and Segmentation
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Reflection Sound Speed Attenuation
Reflection Sound Speed AttenuationFusion
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Volumetric 3-D / 4-D+ Imaging
Operator independent imaging of entire breast volume.
No compression or ionization.
Exam time < 1 minute.
Operator independent imaging of entire breast volume.
No compression or ionization.
Exam time < 1 minute.
Y
Z
X
Tim
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Tim
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ResultsChemotherapy patients
Reflection image
Attenuation (blue) and sound speed (red) added Sound speed added (red)
Strong sound speed enhancementStrong attenuation
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4-D Imaging of Tumor
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ResultsQuantifying Breast Cancer Risk
Santen, R J, Mansel, R. Benign breast disorders. N Engl J Med, 2005. 353(3): p. 275-85.
• Known correlation between breast density and cancer risk
• Currently measured by mammography
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Our approachThresholding and clustering
Sound Speed
Tomogram
Segmented Mammogram Segmented
Ultrasound Percent Density (USPD)
Our study has established equivalence of sound speed and mammographic density potential for ultrasonic measure of breast density
Glide, C., Duric, N., Littrup, P. A Novel Approach to Evaluating Breast Density Utilizing Ultrasound Tomography. Medical Physics. Vol. 34 (2), pp. 744-753. Feb. 2007.
Potential Application: Chemoprevention and risk screening
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SummarySimilarities and Differences
Medical AstronomicalNear Field Far FieldInteractive PassiveSuper-resolution* Diffraction limitedStructure noise Thermal noiseScreening SurveysDiagnostic Targeted ImagingCharacterization Spectral analysisFunctional KinematicalROC analysis ?????
*Simonetti, Huang, Duric, Rama. Imaging beyond the Born approximation: An experimental investigation with an ultrasonic ring array. Physical Review E 76, 036601 (2007)
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NGC 5055
Astronomical style Medical style
Walter and Leroy
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Acknowledgments
• We acknowledge support from following grants:– Sponsor: NCI - Avon,– Improvements in Ultrasound Tomography for Characterization of
Breast Masses: Duration: 12/06 – 11//07– Sponsor: MEDC– Clinical Validation of CURE: A Novel Technology for Improved
Breast Cancer Diagnosis: Duration: 02/07 – 05/09– Komen Foundation grant.– Sound Speed as a Possible Predictor of Breast Cancer Risk.:
Duration: 09/07-08/09.– Sponsor: Susan G. Komen foundation
• Further reading: Duric, N., Littrup, P., Poulo, L., Babkin, A., Pevzner, R., Holsapple, E., Rama, O., Glide, C. Detection of Breast Cancer With Ultrasound Tomography: First Results with the Computerized Ultrasound Risk Evaluation (C.U.R.E) Prototype. Medical Physics Vol 34 (2), pp. 773-785. Feb 2007.
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Structure noise and filtering
Measures Fibrous Stroma And Glandular tissue
Glandular Tissue defined largely by non-specular reflections
Fibrous Stroma defined by specular reflections
Reflection Image