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Bradley W. Christian, McLennan Community College© 2016 Pearson Education, Inc.
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Chapter 20: Antimicrobial Drugs
History Antimicrobials Mode of Action
Today and the FutureResistance
FINAL ROUND
© 2016 Pearson Education, Inc.
Topic 1: History $100 Question
The birth of modern chemotherapy is creditedto the efforts of
a. Alexander Fleming.b. Paul Ehrlich.c. Robert Koch.d. Louis Pasteur.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 1: History $100 Answer
The birth of modern chemotherapy is creditedto the efforts of
a. Alexander Fleming.b. Paul Ehrlich.c. Robert Koch.d. Louis Pasteur.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 1: History $200 Question
In 1928, who observed that the growth of bacteriawas inhibited on a Petri plate contaminated by amold?
a. Alexander Flemingb. Paul Ehrlichc. Robert Kochd. Louis Pasteur
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 1: History $200 Answer
In 1928, who observed that the growth of bacteriawas inhibited on a Petri plate contaminated by amold?
a. Alexander Flemingb. Paul Ehrlichc. Robert Kochd. Louis Pasteur
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 1: History $300 Question
What was the FIRST antibiotic discovered?
a. tetracyclineb. erythromycinc. streptomycind. penicillin
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 1: History $300 Answer
What was the FIRST antibiotic discovered?
a. tetracyclineb. erythromycinc. streptomycind. penicillin
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 1: History $400 Question
In World War II, which of the following made it clear that antimicrobial agents could be effective against systemic bacterial infections?
a. sulfa drugs b. penicillinc. tetracyclined. erythromycin
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 1: History $400 Answer
In World War II, which of the following made it clear that antimicrobial agents could be effective against systemic bacterial infections?
a. sulfa drugs b. penicillinc. tetracyclined. erythromycin
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 1: History $500 Question
More than half of our antibiotics are produced byspecies of
a. Mycobacterium.b. Streptomyces. c. Clostridium.d. Bacillus.
ANSWER
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© 2016 Pearson Education, Inc.
Topic 1: History $500 Answer
More than half of our antibiotics are produced byspecies of
a. Mycobacterium.b. Streptomyces. c. Clostridium.d. Bacillus.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $100 Question
Which of the following are the easiest to treat withantimicrobial agents?
a. virusesb. fungic. bacteria d. protozoa
ANSWER
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© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $100 Answer
Which of the following are the easiest to treat withantimicrobial agents?
a. virusesb. fungic. bacteria d. protozoa
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© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $200 Question
One disadvantage to using broad-spectrumantibiotics is that they
a. destroy normal microbiota.b. are easily inactivated by the host.c. are extremely toxic.d. target host cells.
ANSWER
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© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $200 Answer
One disadvantage to using broad-spectrumantibiotics is that they
a. destroy normal microbiota.b. are easily inactivated by the host.c. are extremely toxic.d. target host cells.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $300 Question
Practically ALL antibiotic-producing microbes have a(n) ________ process.
a. toxin-producingb. sporulationc. motilityd. encapsulation
ANSWER
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© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $300 Answer
Practically ALL antibiotic-producing microbes have a(n) ________ process.
a. toxin-producingb. sporulationc. motilityd. encapsulation
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© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $400 Question
If an antibiotic prevents bacteria from growing, then its action is termed
a. bactericidal.b. selectively toxic.c. bacteriostatic. d. toxic.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $400 Answer
If an antibiotic prevents bacteria from growing, then its action is termed
a. bactericidal.b. selectively toxic.c. bacteriostatic. d. toxic.
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© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $500 Question
Which of the following antimicrobials has thebroadest spectrum of activity?
a. streptomycinb. isoniazidc. penicillin Gd. tetracycline
ANSWER
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© 2016 Pearson Education, Inc.
Topic 2: Antimicrobials $500 Answer
Which of the following antimicrobials has thebroadest spectrum of activity?
a. streptomycinb. isoniazidc. penicillin Gd. tetracycline
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $100 Question
Penicillin works by inhibiting ________ synthesis.
a. proteinb. cell wallc. plasma membraned. nucleic acid
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $100 Answer
Penicillin works by inhibiting ________ synthesis.
a. proteinb. cell wallc. plasma membraned. nucleic acid
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $200 Question
Eukaryotes have 80S ribosomes whereas prokaryotes have ________ ribosomes.
a. 90Sb. 80S c. 70S d. 60S
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $200 Answer
Eukaryotes have 80S ribosomes whereas prokaryotes have ________ ribosomes.
a. 90Sb. 80S c. 70S d. 60S
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $300 Question
The relationship between the antimetabolite sulfanilamide and para-aminobenzoic acid (PABA) is an example of
a. antagonism.b. competitive inhibition.c. synergism.d. bacteriostasis.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $300 Answer
The relationship between the antimetabolite sulfanilamide and para-aminobenzoic acid (PABA) is an example of
a. antagonism.b. competitive inhibition.c. synergism.d. bacteriostasis.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $400 Question
The mode of action of chloramphenicol is to
a. inhibit cell wall synthesis.b. inhibit nucleic acid synthesis.c. injure the plasma membrane.d. inhibit protein synthesis.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $400 Answer
The mode of action of chloramphenicol is to
a. inhibit cell wall synthesis.b. inhibit nucleic acid synthesis.c. injure the plasma membrane.d. inhibit protein synthesis.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $500 Question
The mode of action of antifungal drugs that target sterols is to
a. inhibit the synthesis of essential metabolites.b. injure the plasma membrane. c. inhibit nucleic acid synthesis.d. inhibit cell wall synthesis.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 3: Mode of Action $500 Answer
The mode of action of antifungal drugs that target sterols is to
a. inhibit the synthesis of essential metabolites.b. injure the plasma membrane. c. inhibit nucleic acid synthesis.d. inhibit cell wall synthesis.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$100 Question
Bacteria that are resistant to large numbers ofantibiotics are popularly termed
a. superbugs. b. superinfections.c. MRSA.d. mutants.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$100 Answer
Bacteria that are resistant to large numbers ofantibiotics are popularly termed
a. superbugs. b. superinfections.c. MRSA.d. mutants.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$200 Question
If one measures a large zone of inhibition in adisk-diffusion test, one can assume that thebacteria are
a. sensitive to the antibiotic.b. resistant to the antibiotic.c. unaffected by the antibiotic.d. producing the antibiotic.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$200 Answer
If one measures a large zone of inhibition in adisk-diffusion test, one can assume that thebacteria are
a. sensitive to the antibiotic.b. resistant to the antibiotic.c. unaffected by the antibiotic.d. producing the antibiotic.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$300 Question
Which of the following is NOT a method ofantibiotic misuse?
a. prescribing antibiotics for the common coldb. finishing the full regimenc. using outdated antibioticsd. using antibiotics in animal feed
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$300 Answer
Which of the following is NOT a method ofantibiotic misuse?
a. prescribing antibiotics for the common coldb. finishing the full regimenc. using outdated antibioticsd. using antibiotics in animal feed
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$400 Question
What was the FIRST penicillinase-resistant drug to be developed?
a. vancomycinb. penicillin Gc. methicillin d. clavulanic acid
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$400 Answer
What was the FIRST penicillinase-resistant drug to be developed?
a. vancomycinb. penicillin Gc. methicillin d. clavulanic acid
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$500 Question
Gram-negative bacteria are relatively more resistant to antibiotics because
a. they are too small for the antibiotic to attack.b. they all have capsules that resist antibiotics.c. their cell wall restricts absorption of
molecules through porins.d. they secrete antibiotic-destroying compounds.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 4: Resistance$500 Answer
Gram-negative bacteria are relatively more resistant to antibiotics because
a. they are too small for the antibiotic to attack.b. they all have capsules that resist antibiotics.c. their cell wall restricts absorption of
molecules through porins.d. they secrete antibiotic-destroying compounds.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $100 Question
Assessing the risks and benefits whenadministering drugs is termed
a. the therapeutic index.b. the assessment index.c. therapeutic management.d. assessment management.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $100 Answer
Assessing the risks and benefits whenadministering drugs is termed
a. the therapeutic index.b. the assessment index.c. therapeutic management.d. assessment management.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $200 Question
Seventy percent of antibiotics produced in the United States are
a. used for treating disease.b. exported to other countries.c. used in animal feed to promote growth.d. available over the counter.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $200 Answer
Seventy percent of antibiotics produced in the United States are
a. used for treating disease.b. exported to other countries.c. used in animal feed to promote growth.d. available over the counter.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $300 Question
The chemotherapeutic effect of two drugs given simultaneously that is greater than the effect of either given alone is known as
a. symbiosis.b. commensalism.c. synergism. d. antagonism.
ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $300 Answer
The chemotherapeutic effect of two drugs given simultaneously that is greater than the effect of either given alone is known as
a. symbiosis.b. commensalism.c. synergism. d. antagonism.
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $400 Question
Which of the following is NOT a way to prevent the development of resistance?
a. using broad-spectrum antibiotics when possible
b. always finishing the full regimen of antibioticsc. never using leftover antibiotics to treat new
illnessd. avoiding unnecessary prescriptions ANSWER
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $400 Answer
Which of the following is NOT a way to prevent the development of resistance?
a. using broad-spectrum antibiotics when possible
b. always finishing the full regimen of antibioticsc. never using leftover antibiotics to treat new
illnessd. avoiding unnecessary prescriptions
BACK TO GAME
© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $500 Question
Magainins and squalamine are examples of what defense system produced by MOST forms of life?
a. complement systemb. antibodiesc. interferonsd. antimicrobial peptides
ANSWER
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© 2016 Pearson Education, Inc.
Topic 5: Today and the Future $500 Answer
Magainins and squalamine are examples of what defense system produced by MOST forms of life?
a. complement systemb. antibodiesc. interferonsd. antimicrobial peptides
BACK TO GAME
© 2016 Pearson Education, Inc.
FINAL ROUND Question
Russian scientists have experimented with what agents as a means of therapy for killing pathogenic bacteria?
a. helminthsb. bacteriophagesc. fungid. protozoa
ANSWER
BACK TO GAME