SJOGREN’S SYNDROMEthe ultimate

integrative approachAlexander R Shikhman MD PhD FACR

Gluten Free Remedies

SJOGREN’S SYNDROME

SJOGREN’S SYNDROMEkey pathologic mechanisms

• Reactivation of dormant viral infections, such as EBV and CMV• TH1/TH2 imbalance with TH1 predominance• Increased proliferation of Th17 cells• Production of anti-SSA/Ro and anti-SSB/La autoantibodies• Increased production muscarinic M3 receptor antibodies and

correspondent suppression of water channel protein aquaporin-5• Decreased methylation of epithelial cells in exocrine gland

SJOGREN’S SYNDROMEgoals of therapy

• Improve dryness• Normalize autoimmune responses• Prevent malignancies

THE ULTIMATE RECIPE• Improve dryness

SalivaStimBlack Currant Seed OilKrill oil

• Normalize autoimmune responsesArtemisininCordyceps SinensisN-AcetylcysteineI3C/DIMBlack Currant Seed Oil Krill Oil

• Normalize defective methylation of epithelial cells

TMG Plus

• Prevent malignanciesArtemisininI3C/DIMSalivaStim

ARTEMISININ• Inhibition of EBV and CMV• Inhibition of TH1 responses• Inhibition of Th17 responses• Inhibition of B cell proliferation and autoantibody formation

SalivaStim• Increase of water channel aquaporin-5 protein expression• Increase of tear and saliva production

N-ACETYLCYSTEINE • Optimization of TH1/2 and Th17 responses• Antioxidant activity

I3C/DIM• Optimization of Th1/2 response• Protection of salivary and lacrimal glands from the

immunostimulatory effects of estrogens• Anti-viral activity• Protection of epithelial cells lining salivary and lacrimal glands

BLACK CURRANT SEED OIL/KRILL OIL

• Normalization of TH1/TH2 responses• Inhibition of inflammation

CORDYCEPS SINENSIS• Optimization of TH1/TH2 responses• Synergistic effect with Artemisinin

THE DOSAGE REGIMEN• SalivaStim 1000mg in the AM &

500 – 1000mg at 3-4:00pm• Black Currant Seed Oil 2000mg a day• Krill Oil 2000mg a day• Artemisinin 100 mg up to 600mg a day • Cordyceps Sinensis750 – 1500mg in the AM &

at 3 – 4:30pm• N-Acetylcysteine up to 2400mg a day• I3C/DIM up to 1600mg a day • TMG Plus 600-1200mg in the AM

ADJUNCT THERAPYImprovement of intestinal health• Digestive enzymes• Triphala• Probiotics• Prebiotics• Leaky Gut Day,Night, Probiotics

Candida/yeast overgrowth control• Candidacillin• Black Walnut Hulls• Berberine