CD4+CD25+ nTreg cells

Master switch of peripheral tolerance

Reliable biomarkers for CD4+CD25+ regulatory T cells?

CD25

CTLA-4GITR

CD103 Galectin-1

Ly6

OX-40

4-1BB

Unidentified X,Y,Z ??

Neuropilin-1

CD4+CD25+

RegulatoryT cell

Piccirillo et al. Trends in Immunology July 2004

NO marker after T cell activation.

Only in the naïve T cell repertoire.

Need better marker.