This  document  is  licensed  for  use  under  a  Crea3ve  Commons  A6ribu3on-­‐Noncommercial-­‐Share  Alike  3.0  Unported  License                                                                                                                                                                  September  2014    

 Vaccine  Biosciences  group  

The  problem  Infec1ous  livestock  diseases  feature  prominently  among  the  constraints  that  impede  livestock  agriculture.  Vaccines  can  reduce  the  high  rates  of  livestock  mortality  and  morbidity  and  are  the  most  effec1ve  inven1ons  for  disease  control,  especially  in  under-­‐resourced  agricultural  systems.  

Vaccine-­‐based  solu3ons:  The  goal  of  ILRI’s  Vaccine  Biosciences  group  is  to  build  a  hub  of  research  excellence  dedicated  to  developing  vaccine-­‐based  solu1ons  to  reduce  disease  burdens  that  limit  livestock  produc1vity  in  smallholder  and  pastoral  farming  systems.      

New  science,  new  opportuni3es:  Paradigm  shiEs  in  science,  underpinned  by  whole  genome  sequence  informa1on,  high  throughput  screening  methods  and  informa1cs;  now  enable  accelera1on  of  the  pace  of  research  by  adop1ng  a  holis1c  approach  to  vaccine,  diagnos1cs  and  therapeu1cs  development.  

A  focused  approach:  ILVAC  with  several  partners  is  ini1ally  focusing  on  a  set  of  priority  diseases:  African  swine  fever  (ASF),  contagious  bovine  pleuropneumonia  (CBPP),  East  Coast  fever  (ECF),  peste  de  pe1ts  ruminants  (PPR)  and  RiE  Valley  fever  (RVF).    The  crea1on  of  a  vaccine  research  plaQorm,  where  generic  techniques  and  processes  will  be  implemented,  gives  us  the  ability  to  tackle  other  disease  constraints.  These  ac1vi1es  are  aligned  with  the  CGIAR  Research  Program  on  Livestock  and  Fish.    New  genera3on  vaccines,  a  risky  but  high-­‐reward  venture:  This  research  is  complex  in  nature  and  requires  long-­‐term  investments.  Several  lead  vaccine  molecules  for  CBPP,  ECF  and  RVF  have  been  iden1fied,  while  research  on  ASF  is  just  star1ng  and  PPR  work  is  under  discussion.  

 Achieving  impact:  To  meet  its  objec1ves  and  achieve  impact  in  the  discovery  to  delivery  pathway  ILVAC  works  with  the  BecA-­‐ILRI  Hub,  CGIAR  Research  Programs,  as  well  as  na1onal  and  regional  academic,  public,  private  and  development  sectors.  

Vaccinology  capacity  ques1ons  

•  How  do  we  s3mulate  and  sustain  African  vaccine  R&D  pathways  to  achieve  impact?  

 •  How  can  we  grow  a  biotech  

and  vaccine  manufacturing  sector  in  Africa?  

ilri-­‐vaccines@cgiar.org  

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BASIC&RESEARCH&&

Increase&our&knowledge&base&&

“Knowledge&lays&the&founda>on&for&science&&&innova>on”&

APPLIED&RESEARCH&!

Develop&new&vaccines&&&diagnos>cs&!

“Vaccines&are&highly&effec>ve&an>Idisease&interven>ons”&

! Study&hostIpathogen&interac>ons&&! Map&immune&responses&to&infec>on&

! Characterize&pathogen&virulence&

!  Inves>gate&disease&epidemiology&

! Dissect&pathogen&biology&&&diversity&

!  Iden>fy&candidate&vaccine&and&diagnos>c&molecules&

! Assess&candidate&vaccine&molecules&

! Assess&aMenuated&pathogens&

! ThermoIstabilize&vaccines&

! Develop&easy&to&use&diagnos>c&tools&

! Assess&different&vaccina>on&systems&

! Facilitate&transla>on&of&research&outputs&to&commercial&products&

Vish  Nene  v.nene@cgiar.org  ●  P.O.  Box  30709-­‐00100  Nairobi,    Kenya    ●    +254  20  422  3000    hdp://ilvac.net  ●      www.ilri.org  

Plan3ng  the  orchard  –  an  ILRI  livestock  vaccine  ini3a3ve  (ILVAC)  Vish  Nene   September  2014