Planting the orchard – an ILRI livestock vaccine initiative (ILVAC)
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This document is licensed for use under a Crea3ve Commons A6ribu3onNoncommercialShare Alike 3.0 Unported License September 2014 Vaccine Biosciences group The problem Infec1ous livestock diseases feature prominently among the constraints that impede livestock agriculture. Vaccines can reduce the high rates of livestock mortality and morbidity and are the most effec1ve inven1ons for disease control, especially in underresourced agricultural systems. Vaccinebased solu3ons: The goal of ILRI’s Vaccine Biosciences group is to build a hub of research excellence dedicated to developing vaccinebased solu1ons to reduce disease burdens that limit livestock produc1vity in smallholder and pastoral farming systems. New science, new opportuni3es: Paradigm shiEs in science, underpinned by whole genome sequence informa1on, high throughput screening methods and informa1cs; now enable accelera1on of the pace of research by adop1ng a holis1c approach to vaccine, diagnos1cs and therapeu1cs development. A focused approach: ILVAC with several partners is ini1ally focusing on a set of priority diseases: African swine fever (ASF), contagious bovine pleuropneumonia (CBPP), East Coast fever (ECF), peste de pe1ts ruminants (PPR) and RiE Valley fever (RVF). The crea1on of a vaccine research plaQorm, where generic techniques and processes will be implemented, gives us the ability to tackle other disease constraints. These ac1vi1es are aligned with the CGIAR Research Program on Livestock and Fish. New genera3on vaccines, a risky but highreward venture: This research is complex in nature and requires longterm investments. Several lead vaccine molecules for CBPP, ECF and RVF have been iden1fied, while research on ASF is just star1ng and PPR work is under discussion. Achieving impact: To meet its objec1ves and achieve impact in the discovery to delivery pathway ILVAC works with the BecAILRI Hub, CGIAR Research Programs, as well as na1onal and regional academic, public, private and development sectors. Vaccinology capacity ques1ons • How do we s3mulate and sustain African vaccine R&D pathways to achieve impact? • How can we grow a biotech and vaccine manufacturing sector in Africa? [email protected] An#body technologies Vaccine technologies Cellular technologies Diagnos#c technologies Genomic technologies Contagious bovine pleuropneumonia East Coast fever African swine fever Consor#a for research & product development and capacity development Private sector GALVmed CRPs NARS InterEgov agencies Improved vaccines and diagnos#c tools Peste des pe##s ruminants RiF Valley fever Infec#ous disease research: basic & applied ILVAC – a vaccine plaIorm BASIC RESEARCH Increase our knowledge base “Knowledge lays the founda>on for science & innova>on” APPLIED RESEARCH Develop new vaccines & diagnos>cs “Vaccines are highly effec>ve an>I disease interven>ons” ! Study hostIpathogen interac>ons ! Map immune responses to infec>on ! Characterize pathogen virulence ! Inves>gate disease epidemiology ! Dissect pathogen biology & diversity ! Iden>fy candidate vaccine and diagnos>c molecules ! Assess candidate vaccine molecules ! Assess aMenuated pathogens ! ThermoIstabilize vaccines ! Develop easy to use diagnos>c tools ! Assess different vaccina>on systems ! Facilitate transla>on of research outputs to commercial products Vish Nene [email protected] ● P.O. Box 3070900100 Nairobi, Kenya ● +254 20 422 3000 hdp://ilvac.net ● www.ilri.org Plan3ng the orchard – an ILRI livestock vaccine ini3a3ve (ILVAC) Vish Nene September 2014
Transcript of Planting the orchard – an ILRI livestock vaccine initiative (ILVAC)
This document is licensed for use under a Crea3ve Commons A6ribu3on-‐Noncommercial-‐Share Alike 3.0 Unported License September 2014
Vaccine Biosciences group
The problem Infec1ous livestock diseases feature prominently among the constraints that impede livestock agriculture. Vaccines can reduce the high rates of livestock mortality and morbidity and are the most effec1ve inven1ons for disease control, especially in under-‐resourced agricultural systems.
Vaccine-‐based solu3ons: The goal of ILRI’s Vaccine Biosciences group is to build a hub of research excellence dedicated to developing vaccine-‐based solu1ons to reduce disease burdens that limit livestock produc1vity in smallholder and pastoral farming systems.
New science, new opportuni3es: Paradigm shiEs in science, underpinned by whole genome sequence informa1on, high throughput screening methods and informa1cs; now enable accelera1on of the pace of research by adop1ng a holis1c approach to vaccine, diagnos1cs and therapeu1cs development.
A focused approach: ILVAC with several partners is ini1ally focusing on a set of priority diseases: African swine fever (ASF), contagious bovine pleuropneumonia (CBPP), East Coast fever (ECF), peste de pe1ts ruminants (PPR) and RiE Valley fever (RVF). The crea1on of a vaccine research plaQorm, where generic techniques and processes will be implemented, gives us the ability to tackle other disease constraints. These ac1vi1es are aligned with the CGIAR Research Program on Livestock and Fish. New genera3on vaccines, a risky but high-‐reward venture: This research is complex in nature and requires long-‐term investments. Several lead vaccine molecules for CBPP, ECF and RVF have been iden1fied, while research on ASF is just star1ng and PPR work is under discussion.
Achieving impact: To meet its objec1ves and achieve impact in the discovery to delivery pathway ILVAC works with the BecA-‐ILRI Hub, CGIAR Research Programs, as well as na1onal and regional academic, public, private and development sectors.
Vaccinology capacity ques1ons
• How do we s3mulate and sustain African vaccine R&D pathways to achieve impact?
• How can we grow a biotech
and vaccine manufacturing sector in Africa?
ilri-‐[email protected]
An#body(technologies(
Vaccine(technologies(
Cellular(technologies(
Diagnos#c(technologies(
Genomic(technologies(
Contagious(b
ovine(
pleuropneumonia((
East(C
oast(fe
ver(
Africa
n(sw
ine(fe
ver((
Consor#a(for(research(&(product(development(and(capacity(development(
Private(sector(
GALVmed(
CRPs(
NARS(
InterEgov(
agencies(
Improved(vaccines(and(
diagnos#c(tools(
Peste
(des(p
e##s(ru
minants((
RiF(Valley(fe
ver(
Infec#ous(disease(
research:(basic(&(applied(
ILVAC(–(a(vaccine(plaIorm(
BASIC&RESEARCH&&
Increase&our&knowledge&base&&
“Knowledge&lays&the&founda>on&for&science&&&innova>on”&
APPLIED&RESEARCH&!
Develop&new&vaccines&&&diagnos>cs&!
“Vaccines&are&highly&effec>ve&an>Idisease&interven>ons”&
! Study&hostIpathogen&interac>ons&&! Map&immune&responses&to&infec>on&
! Characterize&pathogen&virulence&
! Inves>gate&disease&epidemiology&
! Dissect&pathogen&biology&&&diversity&
! Iden>fy&candidate&vaccine&and&diagnos>c&molecules&
! Assess&candidate&vaccine&molecules&
! Assess&aMenuated&pathogens&
! ThermoIstabilize&vaccines&
! Develop&easy&to&use&diagnos>c&tools&
! Assess&different&vaccina>on&systems&
! Facilitate&transla>on&of&research&outputs&to&commercial&products&
Vish Nene [email protected] ● P.O. Box 30709-‐00100 Nairobi, Kenya ● +254 20 422 3000 hdp://ilvac.net ● www.ilri.org
Plan3ng the orchard – an ILRI livestock vaccine ini3a3ve (ILVAC) Vish Nene September 2014
