Molecular Hydrogen “An idea and pharmaceutical whose time has come” a food and nutraceutical ….

Molecular Hydrogen “An idea whose time has come” History

Historical applications:-Dirigible-until the Hindenberg Incident-Hydrogenation of oil-until vascular incidents-Inert and non toxic-useless in biomedical-Industrial gas for welding, petroleum refining,

and industrial chemical engineering-No historical medical uses prior to 1976

Molecular Hydrogen “An idea whose time has come”

The paradigm shifts

First hint of useful bio-activity:

Molecular Hydrogen “An idea whose time has come”

Early roadblocks

-Fyfe and Dole publish in AAAS “Science”-University sees hyperbaric hydrogen as insurance

liability ,“a bomb”, and orders apparatus to be deconstructed.

-No interest by medical or private industry to put molecular hydrogen into any product pipeline

-Inertness of molecular hydrogen questioned

Molecular Hydrogen “An idea whose time has come”

Safety to humans established

-Molecular hydrogen finds application in diving gas mixtures

-Still considered inert and biomedically useless-Safe long term use established….GRAS

Molecular Hydrogen “An idea whose time has come”hyperbaric H2 physiological effects

Molecular Hydrogen “An idea whose time has come”hyperbaric H2- 3 decades after seminal paper

Molecular Hydrogen “An idea whose time has come”

Hydrogen water

-Spas market special spring waters as therapeutic-H2 levels at homeopathic levels of 4-6 ppm-Easily dismissed as a mineral water with an added

placebo effect-Investigation begins to separate fact from fancy

Molecular Hydrogen “An idea whose time has come”Fringe medicine publishes data

Molecular Hydrogen “An idea whose time has come”Explosion of interest begins

Fig.?1 Illustration of the generation and scavenging systems of reactive oxygen species (ROS) in mitochondria. Superoxide radical anions (<ce:glyph name="rad"/> O<ce:inf loc="post"> 2</ce:inf> <ce:sup loc="post"> ?</ce:sup> ) are generated by the...

Shigeo Ohta

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

Biochimica et Biophysica Acta (BBA) - General Subjects Volume 1820, Issue 5 2012 586 - 594

http://dx.doi.org/10.1016/j.bbagen.2011.05.006

Molecular Hydrogen “An idea whose time has come”Future directions

-Hydrogen water at 4-6ppm has benefits

-Lactulose produces H2 in gut but benefits are skewed by poor bioavailability and catabolism by other microflora

-Inhaled H2 poses explosion hazards to dwellings, requires contracts and specialized equipment

Molecular Hydrogen “An idea whose time has come”

Future directions

-What if there were a simple way to increase bioavailabilty with no need for dispensing equipment or hazards of explosive gases?

-What if the delivery mode was marketable as food or food supplement that would slowly diffuse molecular hydrogen into body fluids, lungs and tissues of all descriptions?

Molecular Hydrogen “An idea whose time has come”

Future directions

INVENTOR : JOHNSON , MORRIS, F. , whose complete address is of SW34-01-16-W2, BOX 10, BEAUBIER , SASKATCHEWAN , CELL PHONE 701-240-9411, email lifespan.pharma.inc@gmail.com CANADA  Method to use a stable foam composed of bubbles of various food/ supplement/ cosmetic/ pharmaceutical substances to increase the bio-availability of otherwise inert molecular hydrogen gas for medically useful health maintenance , health promotion, anti-aging and generalized disease process interference purposes in biological living systems in a manner which manages regulatory and insurance risks and impediments to mass commercialization.

Molecular Hydrogen “An idea whose time has come”

Future directions

Molecular Hydrogen “An idea whose time has come”

Future directions

Molecular Hydrogen “An idea whose time has come”

Future directions

-With the protection of a pending patent would a modest amount of capital launch products and be easily scaleable with contract manufacturing and find distribution channels?

-Would capital partner invest to expand the IP package to include beverages and cosmeceuticals and nutraceuticals?

Molecular Hydrogen “An idea whose time has come”

Future directions-Proposed manufacturing at Food Centre and POS

pilot plant in Saskatoon , Saskatchewan-Business offices in Saskatoon and Lake Alma ,

Saskatchewan-Equity and royalty swap for risk capital.

Morris Johnson, SW34-01-16W2, Box 10Beaubier, Sk., Canada, 701-240-9411

Lifespan.pharma.inc@gmail.com