Commercialization of New Proteins: Feedkind Protein

BIO World Congress MontrealJuly 2017

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Food Security Is the Issue of the Future

By 2050, 9.6B people will demand 75% more protein than currently available

Source: UN World Population Prospects: The 2012 Revision. World agriculture: towards 2030/2050. Food and Agriculture Organization of the United Nations, 2012.

Creating a Sustainable Food Future, World Resources Institute Report 2013-2014: Interim Findings

Our research shows people will spend one-third of any

increase in incomes on a more varied high-protein diet“

”Greg Page – Former Chairman of Cargill

63.9 million tonnes

110.8 million tonnes

2006 Protein Demand 2050 Protein Demand

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• Bacteria (methanotrophs) metabolize methane as their sole source of carbon and energy, producing a nutritious, high-protein biomass

Feedkind Protein is a Premium, non-GMO Ingredient

• Approved for use in the EU, Australia, Ecuador– >10 years of safety data in salmon farming – Safety studies completed in pigs, chickens,

calves, rats, mink, and fox

• Analogous to yeast extract• Supplied dry as powder or pellets; shelf-

life >12 months at ambient temperature

Calysta Production Process

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Methane

Fermentation

Drying

Product Separation

Commercialization Under Way: European Fermentation Center Opens in the UK

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• Operational since Feb, 2017

• Over 5 tonnes produced, up to 50-100 per year

• Demonstrated achievement of yield and productivity metrics in first campaign

• Samples currently available for customers and regulatory agencies

• Partnered with Center for Process Innovation (“CPI”) to facilitate quick build – 9 months from start to finish

• Critical fermentation and analytical staff in place

• Received grant for up to ~£3 million from the UK eRGF

• Access to contract staffing provided by CPI and anaerobic digestion facilities for biogas work

European Fermentation Center in Teesside, England.

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Memphis, TN –Corn Sweetener Terminal & Corn Oil Refinery

OVERVIEW

• Original construction in 1974

as corn sweetener operation.

• Corn sweetener production operations idled in 2014

• Corn sweetener terminal and corn oil refinery operations continue

• 24/7/365 Days a year

Memphis Site View

Planned Memphis Atlantis Build Layout

72%70%

67% 66% 66%62%

56%

47% 42%40%

60%

80%

100%

HerringFishmeal

FeedKind AnchovyFishmeal

Soy PC ActivatedBreweryWaste

Spirulina Corn GlutenMeal

Chlorella Soldier FlyLarva

Major Sources of Aquaculture Protein and New Alternatives

Crude Protein Lipid Crude Fiber Ash

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Superior High Protein Ingredient

• High protein, low ash/fiber are major price drivers

• However! Composition is not the whole story

Source: FAO Feed Ingredients and Fertilizers for Farmed Aquatic Animals, 2009.ADM Arcon SPC composition.

Digestability and nutritional value of Feedkind Protein is higher than super prime fishmeal in this study

Feed Conversion Ratio is the primary driver of profit on the farm; same output of fish for less feed eaten.

Feed Conversion Ratio – Rainbow Trout

* * ** * *

10 PL shrimp per tank, 5-6 tanks per group, 8 weeks growth, fixed feeding scheduleControl diet: 15% fishmeal compared to 100% replacement by Feedkind protein

Significant increase in survival relative to fishmeal dietNo significant difference in total biomass even completely eliminating fishmeal

Improved performance – Vannamei

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Calysta Feedkind proteincompared to alternatives

Bacterialmeal

Insect meal

Fishmeal Feedkind

Protein Digestability(multiple species)

69% 82% 75%-85% 97%

Shrimp Survival (@100% inclusion)

85% 91% 85-91% 97%

Shrimp Growth (@100% inclusion relative to

fishmeal)

85% 51% 100% 100%+

Source: Tlusty et al., 2017. Peer J.Cummins et al., 2017 Aquaculture

Feedkind represents a premium ingredient that performs better than competitors, including fishmeal!

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Superior performance on multiple metricsAquaculture Growth Product Quality Survival / Disease

Atlantic Salmon + = +

Yellowtail = + ND

Shrimp (Vannamei) + ND +

Livestock Growth Product Quality Survival / Disease

Weaning piglets + ND +

Adult Pigs = + =

Cattle = + =

Chicken - + =

Pets Growth Palatability Health

Cats = = +

Dogs = = +

Human Nutrition(PDCAAS)

Palatability Health

+ + NDComparison to performance of equivalent ingredient in a control diet

Feedkind protein has been tested extensively across a wide range of species and markets.

Performance is generally significantly improved on key price metrics

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Barriers to Entry - SCP

• IP: How to protect a natural strain? GMO strains can be protected, but how to overcome consumer acceptance?

• Production technology: How to scale up feedstocks? Mass transfer, surface area, toxicity, safety? Proprietary reactor vs off-the-shelf?

• Product performance: All SCPs are not equivalent! Target species, product profile, inclusion level, digestability, nutritional value, palatability.

• Regulatory approval: Approvals are not generic. Approval bodies will assess potential pathogenicity (species name). New products require extensive safety testing.

• Commercial scale-up: How to cross the valley of death?

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THANK YOU!

Sustainable source of protein with superior impacts on both health and product quality