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The world leader in serving science

Streamline Your Laboratory

Thermo Scientific Dionex Chromeleon CDS Seminar

[Enter location and date here]

Expand to the Enterprise

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Contents

• Introduction• Network Architecture• Centralized Management• Operational Security• Enterprise Tools

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Introduction

• In laboratory often each instrument is controlled by its own software, especially for more sophisticated instruments like a mass spectrometer (MS)

• This has some disadvantages:• Analysts have to learn multiple software packages

• All actions need to be done on the computer next to the instruments

• Maintenance of multiple software packages

• No central data storage

• Solution: One Chromatography Data System (CDS) for the entire laboratory

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Thermo Scientific Chromeleon 7 CDS Streamlines Chromatography

For your entire enterprise

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Network Architecture

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Key Features for an Enterprise Environment

• Networking capabilities• Central data storage

• Choice of database

• Acquiring data to a central Data Vault

• Network failure protection

• Multiple Instrument Control• Instruments from different vendors

• Centralized Administration• License management, license server

• User management

• Security• User management, access control

• Electronic signatures

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Key Features for an Enterprise Environment

• Archiving• Transfer of data to a long term archive

• Backup• Securing installation and configuration data

for emergency restore

• Qualification• Installation, Operational and Performance

Qualification

• Both Software and Instruments

• Integration• LIMS, ELN

• Custom tools

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Chromeleon CDS Domain

Network Capabilities - Client/Server Architecture

LC

LaboratoryWorkstation

IC

Stand-AloneWorkstation

Remote Clientor TS Client

File/Database Server

Citrix / WTS Server

Firewall

InternetMobile Client

LaboratoryWorkstation LC/MS

InstrumentController

Chromeleon Domain Controller (CDC)

VPN

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Centralized Management

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Centralized Management – Administration Console

• Centralized management of entire CDS from one location• Easy administration of

• Licenses

• Scheduler

• User accounts

• Discovery

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Administration Console – License Manager

• Immediate overview of all licenses• Easily reassign licenses, for example when relocating

modules or instruments

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Administration Console - Scheduler

• Automatically move data by combining powerful injection queries with the Scheduler

• Easily organize your system

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Administration Console – User Management

• Comprehensive user management tools to define what users can change and/or access

• Ensures integrity and security of your data

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Administration Console - Discovery

• Easy installation and configuration of enterprise installation: Simply enter Discovery Service location on each PC in Chromeleon Domain

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Administration Console - Discovery

• All computers in the Chromeleon Domain are automatically connected and configured

• Automatically connects: • Data Vaults

• Data Vault services

• User database

• Instruments

• Instrument Controllers

• Distributes settings for:• User management

• Instrument & Client licensing

• Scheduler (archiving tool)

• Custom ePanels

• User profiles

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Operational Security

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Operational Security

• Ensure no data loss due to server crash or network failure• After major server crash, any data stored there can be

restored from backup tapes / images (IT responsibility)• Ensure operation even if the network is down

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Operational Security – Ensuring Operation

• Ensure software license is available• License information cached on all computers and available for 7 days

• Ensure users can logon• Encrypted user database is cached locally

• Ensure users can continue working• Secure XVault™ infrastructure

• Keep instruments running

• Create and run new sequences

• Keep data generated during network failure accessible for processing

• Ensure no loss of data being generated at point of network failure• Network Failure Protection

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Typical Chromeleon Enterprise CDS Installation

• Chromatography Instruments are controlled by an Instrument Controller computer.

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Remote Client

Instrument Controller with XVault

Central Server

XVault

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Typical Chromeleon Enterprise CDS Installation

• Chromatography data is stored in a Data Vault on a central server.

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Remote Client

Instrument Controller with XVault

Central Server

XVault

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Typical Chromeleon Enterprise CDS Installation

• Remote Clients can control the Instruments in the network.• Remote Clients can access the data in the network.

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Remote Client

Instrument Controller with XVault

Central Server

XVault

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Chromeleon CDS - Creating a Sequence

• Sequences are created directly in the network Data Vault.• Sequences are visible and editable from everywhere in the

network.

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Remote Client

Instrument Controller with XVault

Central Server

XVault

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Chromeleon CDS - Preparing to Start Sequence

• When the sequence is put into the Queue, it is transferred to the secure XVault on the Instrument Controller.

• The sequence is visible and editable from everywhere in the network.

Remote Client

Central Server

Instrument Controller with XVault

XVault

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Chromeleon CDS - Running Sequence

• When started the sequence runs locally on the Instrument Controller, and data is synchronized with central server.

• The sequence including data is visible and editable from everywhere.

XVault

Remote Client

Instrument Controller with XVault

Central Server

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Chromeleon CDS - Network Failure

• When the network fails acquisition continues on the secure XVault.

• The sequence including data is visible and editable from the Instrument Controller.

Remote Client

Instrument Controller with XVault

Central Server

XVault

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Chromeleon CDS - Application Availability

• During network failure it is possible to create and start new sequences from the XVault.

Remote Client

Instrument Controller with XVault

Central Server

XVault

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Chromeleon CDS - Network Recovery

• When the network is back, data will be transferred back to the central Data Vault.

• The sequence is again visible and editable from everywhere in the network.

Remote Client

Instrument Controller with XVault

Central Server

XVault

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Enterprise Tools

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Integration to 3rd Party Software

• Interface with any:• LIMS

• SDMS

• ELN

• or any other 3rd party software package!

• A Software Development Kit (SDK) provides a set of development tools that allows users to create special applications which require direct access to the data.• An example is creating an interface to a LIMS platform to automatically

process worklists in the CDS and for the final result to be posted back into the LIMS

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Support Documentation

• Complete set of documentation available:• General

• Project Specific

• Database Installation & Configuration

• Software Installation & Configuration

• Installation Checklists

• These documents are designed to cover all compliance & regulatory requirements

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Summary

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Summary

• Streamline your laboratory - use one CDS to control all chromatography instruments and process and report all data:• Reduced training effort for the laboratory staff – one single software

package instead of several

• Operate all your chromatographic instruments, including MS, using one software

• Highest laboratory uptime and prevention of data loss through Operational Security and secure XVault infrastructure

• Lower operating cost with centralized management of one single software

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Summary – Bringing It All Together

Discovery

Security

AdminConsole

All the tools you need to expand your CDSto the enterprise level!

Network

XVault

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Thank You!

Any Questions?