Review Article: Disorders of Fluids and Electrolytes Acid–Base Problems in Diabetic Ketoacidosis

Kamel S. Kamel, M.D., and Mitchell L. Halperin, M.D.

N Engl J MedVolume 372(6):546-554

February 5, 2015

Summary

• This review focuses on the safe removal of excess hydrogen ions, the administration of sodium bicarbonate, and the possible contribution of intracellular acidosis to the development of cerebral edema in patients with diabetic ketoacidosis.

Indirect Loss of Sodium Bicarbonate Early in the Course of Diabetic Ketoacidosis.

Kamel KS, Halperin ML. N Engl J Med 2015;372:546-554

Coupled and Uncoupled Oxidation of Fatty Acids in Mitochondria.

Kamel KS, Halperin ML. N Engl J Med 2015;372:546-554

Increased Flux through the Sodium–Hydrogen Exchanger 1 Leading to an Increase in the Number of Effective Osmoles in Brain Cells.

Kamel KS, Halperin ML. N Engl J Med 2015;372:546-554