Post on 07-May-2015
BIOFILM DESTRUCTIVE SYSTEM Nkele Davis
Partners: Deborah Ohiani-Jegede, Nick Xydis
Biofilms
Created by free-floating bacteria that adhere to a surface
Form a complex and layered community with extracellular matrix
Biofilms then create more free-floating bacteria
Biofilm Resistance
Resistant to: antibiotics immune
response
Typical response to biofilm growth is to dispose of the infected product
Biofilms and Health Care
Formation on catheters (urinary, heart, respiratory, intravenous etc.)
Prosthetic valves, artificial hips, teeth, contact lenses
CDC reports biofilms are responsible for 65% of infections
Biofilms and Contact Lenses
Improper cleaning methods by users can lead to biofilms forming on contact lens cases
Rates of contamination on contact lens cases vary from 24% to 81%
Contact lens contamination can lead to microbial keratitis, conjunctivitis, staphylococci
Project Scope
Design a product that can destroy biofilms on contact lens cases
Focus on biofilms that cause microbial keratitis
Portable, handheld device Reasonable application time (<1hr) Biofilm inactivation rate of at least 95%
Existing Solutions
Case cleaning happens as a consequence of lens cleaning Heat Hydrogen Peroxide
solutions Multipurpose solutions
Silver impregnated cases to dissuade biofilm formation
Existing Solutions
Purilens Magnetic pedal
on a flexible arm is used to agitate the saline solution and loosen deposits from the lenses
UV light (253.7 nm) is used to disinfect the lenses, case, and saline solution
15 minute application period
Novelens Two chamber
case that keeps lens used solution (containing deposits) separate from fresh solution during the disinfection process to discourage biofilm formation
QuickPure Battery-powered
device which generates ozone as needed from the oxygen in air and bubbles it into barrel to clean and disinfect the lenses and the case
3 minute application period
Existing Solutions
Johnson & Johnson Vision Care
A patent for a lens storage case that uses disinfecting UV radiation to clean lenses and the case
The Compliance Case Co
A patent for a limited use, self destructive contact lens case
case leaks in a pre-determined fashion to alert user of end point of safe utilization
Design Specifications/Requirements
Usability Within 3” x 5” Weight: < 5 lb Operating time: < 1
hours Visual timer display Set up Time: < 30
seconds Sound during
application: < 40 dB Autonomous system,
turns on and off automatically
Waterproof
Economics Cost: < $200 (prescribed
by doctor) Power Draw: < .25kWhr
per application Effectiveness
95% biofilm destruction biofilm growth
prevention No damage to lens case
and lens Durability
meets all other specification requirements after 5 years
Preliminary Analysis
CFU = Colony Forming Unit
Power Draw: ~.25kW
The product will cost $9.03 per year Sound during application <40dB
Sound in a quiet room
Design Schedule
September 30th – Preliminary PresentationOctober 2nd – Preliminary Report Due 5th – Complete User Interviews 7th – Website Operational 9th – DesignSafe Report 11th – Brainstorm Application Types 13th – Brainstorm User Practices 18th – Evaluate/Improve Design Ideas 30th – Progress Presentation/Report
Design Schedule
November 2nd – Narrow Physical Design 8th – Contact Manufacturers 10th – CAD model of Design 15th – List of Materials 16th – Design Verification 22nd – Final Paper Draft 29th – Final Paper RevisionDecember 2nd – Final Presentation 4th – Final Report Due
Organization of Team
Nkele Consumer Liaison, Lead Ergonomics Designer
Deborah Materials Expert, Lead Mechanical Designer
Nick Time Management, Lead Electrical Designer
Shared Client Contact System Integration Informational Research Risk Management Website Upkeep
Questions??