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Editor-in-Chief: Ga%! Ionescu
Deputy Editor:A(%$%a slGeAnu
Editorial Board: V$%! AlexAndrescu, A#'$#& AntonIAdIs,Ja#-Ma% cAVAIllon, A#a cluGru, c$%#!a ceIAnu,ca%"# chIfIrIuc, I%#a codI/, la creMer, Ma%a dAMIAn,
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Editorial Staff: f!a rApIlAt, M$#a trIstAru
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J HJKFL GJ JFL FLGF. A HJFL
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2. B B., " F.., NO AJL #MEF"KLJ LGF #GLJ HQGJ F LK AKKGLGFOL "KLJ CFJ F J DKK; #FOMKF CGJHGJLGF JK, 2011, 23 H.
3. H.A., C J., B== !., F>4 FLGFGF L JK G MHHJ KLJGFLKLF F F MKJK GFGFKLJG FL-FEELGJQ JMK, !* a*3
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CFU/sample no.Group I Group II Group III
No. % No. % No. %> =
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No. % No. % No. %
S. oralis 9 22,5 11 32,3 8 25,8
S. mutans 4 10 5 14,4 3 9,6
S. sanguis 5 12,5 4 11,7 4 12,9
S. salivarius 15 37,5 14 41,14 10 32,2
S. mitis 3 7,5 5 14,4 3 9,6
S. acidominimus 1 2,5 1 2,9 1 3,2Total 37 40 29
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JKF LG 9.6% LJ 6 EGFLK G OJF GJLG-
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1. %= #, %>==> , >=> E, #> ", ">", E . NJQ 9*9448 938 NK FHLFLK OL GFNFLGF F K-LF JLK. e
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3. H . $FMF G FM GJLGGFL L-JHQ GF EJG HJELJK F HJGGFL KLLMK FMLK. M4'44>2006.152: 797-806.
4. ! J, B= , F= " . QHF G MLFK LJHLGGQ AJLJJQ JE C F LFLK FJGF JLG-GFL JLEFL. c*8 r*8* 2004. 38(6):523-529.
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108
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13. A> J, %, = BH, $= A, "F= E%,=> G, = G= J, ' E, F %J,D H', '>= , "J. FGL HJGF-LGJ HLMJ Q KLFLK GL OL FLGQ FKLCD34: L #A'$"-!$ (#LQ FGL A-JL 'FF $FLK GFLE "JGOL-!JKL $F F)KLJQ.J.a.c4.c4. 2005; 45:1574-1579.
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2. != E, ", B> I, J,F= J, , D ', AH, ". LE- MEF FGL HJGFLGJK KGO FFGGFQ-GJEF HLQ LJ J KNGMJF PHGKMJ:HJGFLGFF G FGF K Q NGL FKL-LK.a3*89.a3. 2009; 109:1117-1126.
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D', H !, ". GMJ NF G L HJ-GFLGFF LJ KNGMJF FLGF F LQ NG-MFLJK. A=.A=. 2007; 105:629-640.
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(E) KMHHEFL OL FLGLK (10 $/E' KG-
ME HFF-", 10 E/E' KLJHLGEQF KMHL)
F 20 E '-MLEF, LF OK JMQ QJ
GFLG !G-IM MK (AEJKE-JE) F
FLJM L 2500 JHE GJ 40 EF L 20GC. ALJ K-
EFL JEGN (GFLFF HGQEGJHGFMJ FM-
LJGHK K F J GG K), BCK F $-
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'-MLEF F 2% !C, OJ LO FLJM L
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HF F $-1640 EME KMHHEFL OL
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F KFK G KHKK GJ KHL KG, KM K
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G LG JM L FMEJ G LGJK FMFF L
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JMEFL LG KLK L JLQ F JHJGM-
LQ G L PHJEFL KHKK KNJLQ.$F GMJ PHJEFL HJGLGG, O KLK KLF-
JR HJGMJK LG FM ML KHKK F E
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LLR FE OK HGKLGF F GJK MLMK,
OL L K GK LG GHJLGJ F L KN J
OK KFL OL BLF (100 E/E). A EFFKGF G L KF OK E JMQ, OLGML
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PLF F L HJLGF NLQ OK GHF LJ
OL F (3* ') FLLGF F L FLJ-
EMKMJ KH KKLGF. FQ L ME, EGKL J-
IMFLQ GL GF L L K, OK JGML LG GML-
K L GEF NLQ. DEF L EKFLJ
GG NKKK OK NG. LGF FM
GML 75% G LK FL, L G NN OK NG-
LG HJKJN L FLKLF LJFKL. PHJEFL
OK JJ GML L L KE LE G L Q. ME OK ELJQ KF HMFLMJ
LOF L LGF F K F, NGF GG NK-
KK E. ALJ JEGNF L F, KE
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EF NLQ NGF KHJF K GFLG L KMJ-
FKGF . GEF O OK GK F
QJK. FEK JN HJOJE FGJE KLJ
KF KGMLGF (L 37GC, 5 E HJ 100 GQ OL)
GJ M JKMKLLGF F OJ H EELQ
F K F LEHJLMJ-GFLJG (22GC) F
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ELRLGF, L 22GC LEHJLMJ, 50-60% ME-
LQ, OL J KK LG OLJ F GG. JGMH
OK GEHGK G 10 E:
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JQ) - LJ KGM FG EGJLLQ;2F JGMH - FLN GFLJG C (C' F FL
OL FGJE KF KGMLGF, 300 m/EGMK);
3J JGMH - C' F C-A21-LJL (KLG KGMLGF
2 E/E F FGJE KF KGMLGF, KLJ).
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HJ EGMK, 1 J GJ C', F 150 m (300 m)
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L NLQ.
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BCK, KGL JGE L HJJ GG G LQ
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L Q '$A. JKMLK GLF J HJKFL F
!. 4.
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JK, GJ L FPL 5 QK. GLN HMJKM F LK
PHJEFL OK L LK GF L KMJNN LE.
JKMLK J HJKFL F K 1 F 2.
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PHJEFLK K HJKFL F !. 6.
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(C), L L HFF LJ 24 JK, F L KL
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120
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Mice groupSurvivors
Total No. of deaths No. %
MCS-Ab21 15 10 5 333%
PC 5 0 5 1000%
NC 14 14 0 0%
Total 34 24 10 29
4% 2. = > C!% = ("=-C>) =>= = . B> (G= >>=) =>= > >=.>=- > > > > > =.
Chi2Degrees
of freedom (df)Significance
Log Rank (Mantel-Cox) 14179 2 0001
Breslow (Generalized Wilcoxon) 10
852 2 0
004Tarone-Ware 12560 2 0002
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KJ FLJKL, HGJ G L PLJELK F
QHGLJE F L JKL 48 JK. GE G LE KGO
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G LGL GKLJG F LJQJK (") F L H-
LFL JGMH. GMF EGJL GJJLGF L-
OF $'-17 N F KJME GKLJG (CG).
JKGF GFL KGO KLLKL KFF
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OLF L KE JGMH, LOF L $'-17 N F
LL G KJME LJQJK (H=0.043). JKMLK J
HJKFL F 1 F 2.
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L KJME GFFLJLGF G $'-17 F LGL GKLJG
F LJQJK F L GFLJG JGMH.
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NL GFFLJLGFK G $'-17 J KKGL
OL L HQKGHLGGQ G FMEJGMK FEELGJQ
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JG F LJF L GG JF JJJ 7, 8.
#J EGMFLK G $'-17 F 17 K OJ
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KJME NK G GL $-17 F $'-23 OJ LL F
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126
CQA#Q *9 .
2. C>>= = I!-17 = CH$!
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IL-17 CHOL
IL-17 Pearson Correlation 1 .338(*)
Sig. (2-tailed) 0.033
N 40 40
CHOL Pearson Correlation .338(*) 1
Sig. (2-tailed) .033
N 40 40
1. C>>= = I!-17 = G
c4*943 8 83+39 9 9* 0.05 *;* (2-9*).N: 3'* 4+ 9*398, il-17: 39**3-17, : 83+3*, !G: 9>**8
IL-17 TG
IL-17 Pearson Correlation 1 .322(*)
Sig. (2-tailed) 0.043
N 40
TG Pearson Correlation .322(*) 1
Sig. (2-tailed) .043
N 40 40
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127
I!-17 >>= >
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'EFE'E#CE
1. ! AJ. ALJGKJGKK. LMJ 2000; 407:233-241.2. H=>= G. $FEELGF, ALJGKJGKK F
CGJGFJQ AJLJQ DKK. N e3 J M* 2005; 352:1685-1695.
3. " C, '< = B= J'. CQLGFK FJGNKMJ KK. 'MG BG 2005; 78: 805-818.4. A, " . CQLGFK F LJGKJGKK: HLG-
F F JMLGJQ HLOQK. p>84 r*;. 2006; 85:515-581.
5. C= , J,! , G= E. BG G $FLJMF-17A KMLKF M ALJGKJGKK F AHGHGHJGLF]DFL . c 2010; 121:1746-1755.
7. > J, F "A, C= "J. $FLJMF-17 HJG-MLGF F FLJ FJNGMK KQKLE-FLJLF KF K K KKGL OL LN KK F EM-LH KJGKK.a J p94 2008; 172:146.
8. H, , I= I. #MEF #17 QE-HGQLK HJGEGL GG-JF JJJ KJMHLGF FFLJ FJNGMK KQKLE FEELGF. N9 M*2007;13:1173.
9. >, , *, #, , #. $'-17 F KQFGNMK JGE HLFLK OL JMELG JLJLK K HGLFLKLEMLGJ G GKLGKLGFKK. J c3 i3;*89 1999;103:1345.
10. D, 'H., >, D, B=, '. A FGE-O
KKGLGF KLMQ FLK $'23 K F FEELGJQGO KK F. 2006; 314:1461.11. F=>, , A=>, A, B %, !=>< H,!>== ', == ", H= D. JHMLQ G $'-17 FMLJRLGF F EMJF PHJEFLMLGEEMF FHGEQLK. c* i34 2005;237:123.
15. A>-'> E, #>= G, != A= > F. $FLJMFK 1L F 6 ML FGL LJFK-GJEF JGOL LGJ-L J KKFL GJ L J-FLLGF G FLJMF 17-HJGMF MEF HJK. N9 i34 2007; 8:942.
16. >= # J, B>= , C= J'. DNGHEFL, Q-
LGF HJG F MFLGF G MEF FLJMF 17-HJG-MF HJ K. N9 i34 2007; 8:950.
17. H=>= !E, H>= 'D, "== %', = H," !, " " , C. $FLJMF 17-HJGMF CD4+ LGJ K NGH N FLFL JGE L HJ LQH 1 F 2 FK. N9i34 2005; 6: 1123-1132.
18. % H, ! , = $, C= H, # ', =
H . A KLFL F G CD4 K JMLK LK-KM FEELGF Q HJGMF FLJMF 17. N9i34 2005; 6: 1133-41.
19. >> , A A. 17 K: JGE HJMKJGJK LGHQJK F FEELGF F FLGF. i39 i342008; 21 (5): 489-498.
20. GG, != 'G, !>= C, = #,G> C, = . A MEF FLJMF-12/23EGFGGF FLGQ GJ L LJLEFL G HKGJKK. Ne3 J M*2007; 356: 580-592.
21. "==>= %J, F IJ, " !, E>= C$, =>= J,%= D, D>= B, G>> , !== A. $FLJMF-17 K JM LJL F M-EF KK. !*38 p4 2009; 30(2): 95-103.
128
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129
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EGJ, KLMK OJ GFML GF L JK LGJK
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LMJ G L JKHLN GFLGFK 5.
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K JGF NJ HLLK F F-KL NJ KK
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ML GF L LK G #$ GF HLLK FLGFK
N KGOF LL L JL G HJGJKKGF F GEH-
LGFK JGE NJ HLLK J JL F HLFLK
OL #$ GFLGF 6, 7.
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L EJF L GFJF JHJKFL Q LK
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PL Q L PKLF GFK 8-12.
AGJF LG L KLLKLK HJGN Q L
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J L GMFLJQ OL L KL HJNF G
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HJNF G L GFLGF G 14%. $F L K G L #$/#D GFLGF L KLMQ JGMH GF-
KKL G 5 GFL HJLHFLK F 45 #D-FL HJLHFLK. HJNF G L
#$/#C GFLGF OK 25% GML G L 170 #C-FL HJLHFLK.
L G L GFLGFK GF L PHJKKGF F NK G L FLGF EJJK OK FQR
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130
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GF #DA F L #DA LLGF. CGFJFF
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JGMHK OJ KG LKL GJ L HJKF G
L #$ FLGF GFJE Q L PKLF G
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B>
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131
H4?088 B, C 0=3 D 2>8=5428>= 8= HI+-8=54243 ?084=: ?40;4=24 0=3 ?>64
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JL OL LGK GJ F GLJ KLMK F GJJ LG
KJ F L L LMJK G L GFLGFK.
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GFLGF GFKKL G 16 GFL HJLHFLK F
114 #B-FL HJLHFLK. EF G L
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AK JKML L HJNF G L #$ FLGF EGFKL
L #B KLMQ JGMH OK KKKK LG 14%.
K JGMH PL J JL G #B
EMLHLGF, JL GKK G FL-#BK, J -
NK G #B DA F GOJ A' NK F GEHJ-KGF LG L GFLJG JGMH.
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ML GF 5 GFL HJLHFLK F 45 #D F-
L HJLHFLK OL EF G 25 QJK.
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EF LG 10%.
5 K JGMH HJLHFLK KGO JK
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Type of hepatitis B
infectionHBs Ag HBs Ab HBe Ag HBe Ab HBc Ab
Chronic hepatitis B
infectionwith HBe Ag present
+ - + + -
Chronic hepatitis B
infection
without HBe Ag
+ - - + -
Hidden hepatitis B
infection- - + - +
Carriers of the hepatitis B
virus + - + - +
3. C>= > B =>=
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L JJF LG L K JGMHK L GO CD
4 GMFL F LJLGF G QLGFK OL KH-
LQ LGOJK HLLK NJMKK J GFKJ LG
L EGJ MKK G L FIML EEMF JKHGFK
LG L HLLK FLGFK.
GKJN FK F L PHJKKGF G LKH HLLK EJJK FL L EHL G L
GFLGF OL #$ GF L HJGJKKGF G L H-
LLK FLGFK. $F LGF, L FIML EEMF
JKHGFK LGOJK L HLLK NJMKK F L K G
L GFL HJLHFLK K LG L NGHEFL
G JJGKK F F KL NJ KK.
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NK.
'EFE'E#CE
1. %> ", > C, B=> ', F G *9 . LMJ KLG-JQ G JGF HLLK B F G-FL HLFLK. JH*94 2006;44:65-70.
2. > C. #HLLK B F #MEF $EEMFGFQ JMKCG FLGF. H*94 2009;49:138-145.
3. C= , = C!, > , ! C, != C, CH,GMJ HEGGQ G HLLK D NJMK FLGFEGF FLF JM MKJK OL F OLGML MEFEEMFGFQ NJMK FLGF F OF, J c3M4'4, 2011.
4. H> ! C, CF EHLGFK G #$F HLLK B G-FLGF F AK F AJ, !*l3*9 i3+*948 D8*8*8, 2007, GME 7, $KKM 6,K 402-409.
5. = A , B E CJGF #HLLK B F C:HL GF JHQ, F9* #44>, 2009.
9. = J *9. ., JNF G #HLLK C JMK(#C) $FLGF F #$-HGKLN $FNMK F L -JFK F #C KLF F L $EHL G #C GF #$JLEFL MLGEK,J # H*9, 2010.
10. ' # I, H== J. ., JLEFL G HGHMLGFK L CJGF #HLLK B $FLGF, e=*9r*;*< 4+ G894*39*44> 3 H*944>, 2011.
11. #, != B$, >=> G, H== AB,!= A!, C== %B *9. ., $EHL G HLLK
132
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G L HLLK B FLGF LGOJK F KL NJ
KK. GOJ A' NK KMKL KK HLGQL K-
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16, 17.
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GOJ CD4 GMFL MK Q L HLLK B F-
LGF 18, 19.
HLLK D NJMK K LN NJMK JIM-
JF L HJ MFLGF HJGN Q L HLLK BNJMK F GJJ LG EMLHQ. AK JKML L HLLK DFLGF K FGMFLJ GFQ F HLLK B FL
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GFLGF K KLEL LG GMJ F 5% G L HLFLK
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K JGMH PL GOJ #B NJ G
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EJK JKHGFK G L #B EMLHLGF FM-
FK L PHJKKGF G L #B EJJK.
CGFJFF L #$-#C GFLGF L
FJK NK G #C A OJ GKJN F LK JGMH. $F L K G L #C EGFG-FLGF
L EMLHLGF LK H F L HLGQLK ML
L FMEJ G EMLHLGF KLK FJKK OF L
GFLGF K HJKFL. AK JKML #C F EMLHQ
F L QEHG K K O, KM K EJGHK,
CD4 F CD8 QEHGQLK. J JL G EM-
LHLGF K LG EKKN FJK G #C NJ
G GGOF #$ KJGGFNJKGF 18.
MK, L HJGJKK G L HLLK FLGFK
KEK LG HGKLNQ FMF Q L #$ KJG-
GFNJKGF F L FMEJ G EMLHLGFKLK GJ L HLLK C NJMK JHJKFL Q HLG-
QLK F QEHG K KM K EJGHK, CD4
F CD8 QEHGQLK.
LMK GMK GF L L G L #AA LJ-
HQ GF HLLK C HJGJKK N JN F FJK
F L N G NJ FRQEK F HHJGPELQ 30% G
#$-#C GFL FNMK LJ FFF L
LJLEFL. GE FL-#$ JMK KM K FNJHF,
JLGFNJ F KLNMF J EGJ Q LG MK -
NLGFK F NJ FRQEK 19, 20, 21. EGJLQ G
KLMK GFML GF LK GFLGF GFM LL
#$ JLK L HJGJKKGF G #C-JL NJ
KK 21, 22, 23.
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C NJMK GFLGF GF JKHGFK LG Q LN FL-JLJGNJ LJHQ F GMLGE F #$-FL FN-MK: FLGFO GGJL KLMQ, c3 i3+*9 D8, 2006;42(10):1481-7.
12. >= C E, "= J, HEGGQ G #HLLK CJMK $FLGF F #$-$FL $FNMK: JLEFL
G CJGF #HLLK C F #$ GKLN LFLK,J #H*9, 2008.
13. G> !, C E I *9. ., JNF F K!LGJK G #HLLK C JMK $FLGF F AML GHM-LGF F GEF: LGFO MJNQ 2006-2008, JG89439*893 l;* D8, 2010; 373-379.
14. > ", J HLLK F #$ GFLGF, JH*94, 2008; 48(2):353-67.
15. " $ A, FEFL G #$/#B CGFLGF,M*G*3M*, 2006.
16. C " , #MEF $EEMFGFQ JMK (#$)$FLGF, !* M* M3, 2007.
17. C= ' J, JQ QEHLGEL #$ $FLGF,
M*8*, 2010.18. H J, ! !, #$-#B F #$-#C GFLGFF NJ FJ NGHEFL, c3* !*9*39 3r*8*, 2007, 133, 241-252.
19. " , B, '>>, =, , 2009; 29-92; 117-203.
20. B> , ">= , J> B, H A,%> J, B= , "= D, = DH, # A, AGEHJKGF G JK LGJK GJ #C-EGFG-FLGF,#$-EGFG-FLGF, F #C/#$-G-FLGF F GEEMFLQ KLLF, D D8 , p'M*, 2007.
21. B= C, B>=> ", D, #HLLK C F#$/#C CG-FLGF, N49= ", #C/#$ GFLGF, c3 a'8848
p4, 2008.23. !L== D>= C, = A *9 , DFGKK G
#HL !JGKK F CJJGKK Q JFKFL KLGJHQF #$/#HLLK C JMK-CGFL LFLK,J43 4+
a6* i3* D*+*3> >34*8, 2006.
H4?088 B, C 0=3 D 2>8=5428>= 8= HI+-8=54243 ?084=: ?40;4=24 0=3 ?>64
133
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