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94

(A)$A) AC#$ ! ($CB$'" A)D $(()'"

Editor-in-Chief: Ga%! Ionescu

Deputy Editor:A(%$%a slGeAnu

Editorial Board: V$%! AlexAndrescu, A#'$#& AntonIAdIs,Ja#-Ma% cAVAIllon, A#a cluGru, c$%#!a ceIAnu,ca%"# chIfIrIuc, I%#a codI/, la creMer, Ma%a dAMIAn,

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Editorial Staff: f!a rApIlAt, M$#a trIstAru

totAl publIshInG house

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Indexed In MedLIne

CnCSIS Catgory B+

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104

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1. ! .C., !> J."., ".., C.., != J.., NO:JLGF G #GLJ HQGJ G JNFL "KLJG-MGF DKKK: #LLF GJ F F BJ LL E LGF, !* a;G894*39*4; 2008,111-120.

2. B B., " F.., NO AJL #MEF"KLJ LGF #GLJ HQGJ F LK AKKGLGFOL "KLJ CFJ F J DKK; #FOMKF CGJHGJLGF JK, 2011, 23 H.

3. H.A., C J., B== !., F>4 FLGFGF L JK G MHHJ KLJGFLKLF F F MKJK GFGFKLJG FL-FEELGJQ JMK, !* a*3

J43 4+ M*3*, 2004, . 601-605.9. I "., %> "., C ".C., B A., C>==-

= G., K=K C., H*4'9* >4 MLNLGFJGE KLJ GHKK F KMKHLLQ LG FLGLKMK F EHJ LJHQ, r433 a;*8 4+ M4-'44> 3 i344>, 2011, 70(2):60-64.

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105

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F L GJ FLGFK LGHLGFQ. GE G LE

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CFU/sample no.Group I Group II Group III

No. % No. % No. %> =

SpeciesGroup I (40) (patients) Group II (34) (patients) Group III (31) (patients)

No. % No. % No. %

S. oralis 9 22,5 11 32,3 8 25,8

S. mutans 4 10 5 14,4 3 9,6

S. sanguis 5 12,5 4 11,7 4 12,9

S. salivarius 15 37,5 14 41,14 10 32,2

S. mitis 3 7,5 5 14,4 3 9,6

S. acidominimus 1 2,5 1 2,9 1 3,2Total 37 40 29

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3. H . $FMF G FM GJLGGFL L-JHQ GF EJG HJELJK F HJGGFL KLLMK FMLK. M4'44>2006.152: 797-806.

4. ! J, B= , F= " . QHF G MLFK LJHLGGQ AJLJJQ JE C F LFLK FJGF JLG-GFL JLEFL. c*8 r*8* 2004. 38(6):523-529.

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108

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G J F KNGMJF (1 AC) F QK G 5 EFMLK, LJFLF OL 5-EFMLK OK-GML HJGK

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GO QLGELJQ F EEMFGMGJKF EKMJEFLK, GFKJ FJK F JMLF

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12 GMJK LJ LJLEFL, OL H NM L 24 GMJK LJ KNGMJF EFKLJLGF. K K

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GJJ LG EGFKLJL F FJK F FGL HJG-

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>= = =>= == FEK OJ KJ L KF, 12JK,

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D= => >=> >>= >= >=>==

111

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F. 2. CD34+ = -1+ = >> 12 > > >=. $EEMFGMGJKF(QLGKHF LFIM) HJGJE GF HJHJ GG EGFGFMJ K, HLF KF KLF CD34+ K (A, B),-1+ K (C, D). $F (A) F (C) HK GFLJKL F DA$ J EJ OL L FL EK (B) F (D)

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GM NGJR JQ F F FGLRLGF, K

FGL HLMJ Q FL CD34 FLGQ GN-

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KMHHGJL GJ KLE LJHQ, GL Q FJKF L

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CGFKJF L JKMLK G LK KLMQ, L OGM

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LK G L FKLL HJGFLGFF GF FGL- HJGFLGJ KLE K GFLJMLK LG HJGLLF L

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JGMK L G KE F JHJMKGF FM Q

KMJ HJGMJK.

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FMEJ D/6/1.5//17, bA MJGHF EFKGFG GLGJ KLMK_.

MK LG KKME LL LK GM FGLJ OQ LJGM

O Q HJGFLGFF HQK LK HJL F K-

F L JL JGE KE/JHJMKGF FMJQ.

JGJ, L QHGLKK LL FKLL HJGF-

LGFF K LG EGR F L HJHJ JM-

LGF F FJK FMEJ G FGL HJGFLGJ

K OK GFJE, JIMJF FGO MJLJ FNKL-

LGF G L EHL G GMJ FF GF L KE

JL KML LG FKLL HJGFLGFF.

PL EFKEK LJGM O FGL-

HJGFLGJ KLE K KMKLF L EQGJ JG-

NJQ LJ F KE FKML K KL MH GJ KMKKGF.

A GFKJ FMEJ G PHJEFL KLMK JHGJL

LL GF EJJGO KLE K EGR LJGM K-

E HJGFLGFF J LG JFLL FLG

FGL K GJ EQGQLK 9, 10, 11, ML LQ L

EFQ F HJJF EFFJ 10, 12.

L LL KNGMJF K LG FJK L

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G EGJ F EHGJLF, K LK K JHJKFL

F FGFGMK HGG G JFJLN K, GL FG-

L F EQGJ. AFKLL HJGFLGFF

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113

D= => >=> >>= >= >=>==

11. BE, B< ", , B , ==C, A= C, > ', > G, = %, " H,>= ". FJLGF G MEF FJL JLEMK Q FLJGJGFJQ MLGGGMK GF EJJGO LJFKHFLLGF F JGF GJGFJQ JLJQ KK: L$AC LMQ.J.a.c4.c4. 2005; 46:1651-1658.

12. ", ! , ', > , I> H,I , " ", H . CQLGFK HJG-M Q GF EJJGO K F GFLJML LG MF-LGF EHJGNEFL G L FJL JL Q HJGLLFJGEQGQLK JGE KE FMJQ. a.J.p>84H*9 c.p>84 2006; 291:#886-#893.

13. A> J, %, = BH, $= A, "F= E%,=> G, = G= J, ' E, F %J,D H', '>= , "J. FGL HJGF-LGJ HLMJ Q KLFLK GL OL FLGQ FKLCD34: L #A'$"-!$ (#LQ FGL A-JL 'FF $FLK GFLE "JGOL-!JKL $F F)KLJQ.J.a.c4.c4. 2005; 45:1574-1579.

'EFE'E#CE

1. , ! , "> #, " ", > , " A, I , "- ", H . $KE HJ-GFLGFF FFKL EGRLGF F JJMLEFL G GF EJJGO KLEK LG HJGLL FKL KE/JHJMKGF FMJQ F LL HK.J.a.c4.c4. 2009; 53:1814-1822.

2. != E, ", B> I, J,F= J, , D ', AH, ". LE- MEF FGL HJGFLGJK KGO FFGGFQ-GJEF HLQ LJ J KNGMJF PHGKMJ:HJGFLGFF G FGF K Q NGL FKL-LK.a3*89.a3. 2009; 109:1117-1126.

3. C= DJ, = A', C= "J, $",B #, = 'D,!= J%, G= GC. JGFLGJ LJF K J-ML Q QHGP JFLK LJGM #$!-1 FMLGF G

D!-1. N9.M*. 2004; 10:858-864.4. != E, A J, F= J, ", ", =

D', H !, ". GMJ NF G L HJ-GFLGFF LJ KNGMJF FLGF F LQ NG-MFLJK. A=.A=. 2007; 105:629-640.

5. != E, H> C, B= A, ". "F JMLGJQ GFLJG G EQG-J FJQ ELGKE HJLK HGKLGHJLN J- MFLGF F HLFLK MFJGF G-HMEH GJGFJQJLJQ QHKK JL KMJJQ: FLGF NJKMK FLJN-FGMK FKLLK.a3*89*844>2007; 106:444-457.

6. ' J, > , A , B ', G> . $KGMJF

HJGFLGFF JKK EQGJ FJLGF F J-LK N MH-JMLGF G QHGP FM LGJ 1 LLK EL Q EEEF LJL G JHEQF.

a3*89*844>2008; 108:415-425.7. = C, D, DA, B==

", DC, = J', % %F, J., % %.PLJMJ KF-JML FKK LJJ KGMJFHJGFLGFF GFGELFL OL MHJMLGF GQHGP-FM LGJ-1H F NKMJ FGL- JGOL LGJ PHJKKGF F JLK. a3*89. a3.2006; 103:281-8.

8. F> J, H= ', #C, E D, = #,% B, >

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I#'$D*CI$#

#"B1 (#-GLQ "JGMH BGP HJGLF 1),

EEJ G L -EGLQ JGMH HJGLF KMHJ-

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JK G HJGFEELGJQ QLGFK (.. !, $'-1)

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LQEMK K F MFFL JGEGKGE HJGLF 8.

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114

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ELKLKK G GL EHFL F KHGFLFGMK

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LMEGMJ 29. --3 K OJ EFLF F M-

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ME HFF-", 10 E/E' KLJHLGEQF KMHL)

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GFLG !G-IM MK (AEJKE-JE) F

FLJM L 2500 JHE GJ 40 EF L 20GC. ALJ K-

EFL JEGN (GFLFF HGQEGJHGFMJ FM-

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FLJLGF G 1P106 K/E'. BCK NLQ, E-

KMJ Q LJQHF M, P 98%.

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JQ) - LJ KGM FG EGJLLQ;2F JGMH - FLN GFLJG C (C' F FL

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3J JGMH - C' F C-A21-LJL (KLG KGMLGF

2 E/E F FGJE KF KGMLGF, KLJ).

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HJ EGMK, 1 J GJ C', F 150 m (300 m)

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FE L GEELL AA' - !'AA.

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119

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JK, GJ L FPL 5 QK. GLN HMJKM F LK

PHJEFL OK L LK GF L KMJNN LE.

JKMLK J HJKFL F K 1 F 2.

KMJNN JL GJ L FEK FNGN F C'

PHJEFLK K HJKFL F !. 6.

$F L HGKLN GFLJG JGMH (C), FEK

KMJNN. $F L JKL 36-48 JK LJ L KMJ F-

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KLLMK OK GKJN. $F L FLN GFLJG JGMH

(C), L L HFF LJ 24 JK, F L KL

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120

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!% (1 ). D = > 5 >=>

1. >= > >=

Mice groupSurvivors

Total No. of deaths No. %

MCS-Ab21 15 10 5 333%

PC 5 0 5 1000%

NC 14 14 0 0%

Total 34 24 10 29

4% 2. = > C!% = ("=-C>) =>= = . B> (G= >>=) =>= > >=.>=- > > > > > =.

Chi2Degrees

of freedom (df)Significance

Log Rank (Mantel-Cox) 14179 2 0001

Breslow (Generalized Wilcoxon) 10

852 2 0

004Tarone-Ware 12560 2 0002

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JK; LJ FGL HJELQ; EGMLGF

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G LGL GKLJG F LJQJK (") F L H-

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OF $'-17 N F KJME GKLJG (CG).

JKGF GFL KGO KLLKL KFF

(H=0.033). J OK KG EGJL GJJLGF

OLF L KE JGMH, LOF L $'-17 N F

LL G KJME LJQJK (H=0.043). JKMLK J

HJKFL F 1 F 2.

CGFNJKQ, LJ OK FG GJJLGF LOF

L KJME GFFLJLGF G $'-17 F LGL GKLJG

F LJQJK F L GFLJG JGMH.

DIC*I$#

NL GFFLJLGFK G $'-17 J KKGL

OL L HQKGHLGGQ G FMEJGMK FEELGJQ

F MLGEEMF KKK. $'-17 K F LL F

KGFK G EMLH KJGKK F K N LG N

JG F LJF L GG JF JJJ 7, 8.

#J EGMFLK G $'-17 F 17 K OJ

GMF F L KQFGNME G JMELG JLJLK

HLFLK, GEHJ LG LQ KMLK 9. #

KJME NK G GL $-17 F $'-23 OJ LL F

MJLN GLK F CJGFaK KK 10, 11.

126

CQA#Q *9 .

2. C>>= = I!-17 = CH$!

c4*943 8 83+39 9 9* 0.05 *;* (2-9*).N: 3'* 4+ 9*398, il-17: 39**3-17, : 83+3*, cHol: 4*89*4

IL-17 CHOL

IL-17 Pearson Correlation 1 .338(*)

Sig. (2-tailed) 0.033

N 40 40

CHOL Pearson Correlation .338(*) 1

Sig. (2-tailed) .033

N 40 40

1. C>>= = I!-17 = G

c4*943 8 83+39 9 9* 0.05 *;* (2-9*).N: 3'* 4+ 9*398, il-17: 39**3-17, : 83+3*, !G: 9>**8

IL-17 TG

IL-17 Pearson Correlation 1 .322(*)

Sig. (2-tailed) 0.043

N 40

TG Pearson Correlation .322(*) 1

Sig. (2-tailed) .043

N 40 40

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127

I!-17 >>= >

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'EFE'E#CE

1. ! AJ. ALJGKJGKK. LMJ 2000; 407:233-241.2. H=>= G. $FEELGF, ALJGKJGKK F

CGJGFJQ AJLJQ DKK. N e3 J M* 2005; 352:1685-1695.

3. " C, '< = B= J'. CQLGFK FJGNKMJ KK. 'MG BG 2005; 78: 805-818.4. A, " . CQLGFK F LJGKJGKK: HLG-

F F JMLGJQ HLOQK. p>84 r*;. 2006; 85:515-581.

5. C= , J,! , G= E. BG G $FLJMF-17A KMLKF M ALJGKJGKK F AHGHGHJGLF]DFL . c 2010; 121:1746-1755.

7. > J, F "A, C= "J. $FLJMF-17 HJG-MLGF F FLJ FJNGMK KQKLE-FLJLF KF K K KKGL OL LN KK F EM-LH KJGKK.a J p94 2008; 172:146.

8. H, , I= I. #MEF #17 QE-HGQLK HJGEGL GG-JF JJJ KJMHLGF FFLJ FJNGMK KQKLE FEELGF. N9 M*2007;13:1173.

9. >, , *, #, , #. $'-17 F KQFGNMK JGE HLFLK OL JMELG JLJLK K HGLFLKLEMLGJ G GKLGKLGFKK. J c3 i3;*89 1999;103:1345.

10. D, 'H., >, D, B=, '. A FGE-O

KKGLGF KLMQ FLK $'23 K F FEELGJQGO KK F. 2006; 314:1461.11. F=>, , A=>, A, B %, !=>< H,!>== ', == ", H= D. JHMLQ G $'-17 FMLJRLGF F EMJF PHJEFLMLGEEMF FHGEQLK. c* i34 2005;237:123.

15. A>-'> E, #>= G, != A= > F. $FLJMFK 1L F 6 ML FGL LJFK-GJEF JGOL LGJ-L J KKFL GJ L J-FLLGF G FLJMF 17-HJGMF MEF HJK. N9 i34 2007; 8:942.

16. >= # J, B>= , C= J'. DNGHEFL, Q-

LGF HJG F MFLGF G MEF FLJMF 17-HJG-MF HJ K. N9 i34 2007; 8:950.

17. H=>= !E, H>= 'D, "== %', = H," !, " " , C. $FLJMF 17-HJGMF CD4+ LGJ K NGH N FLFL JGE L HJ LQH 1 F 2 FK. N9i34 2005; 6: 1123-1132.

18. % H, ! , = $, C= H, # ', =

H . A KLFL F G CD4 K JMLK LK-KM FEELGF Q HJGMF FLJMF 17. N9i34 2005; 6: 1133-41.

19. >> , A A. 17 K: JGE HJMKJGJK LGHQJK F FEELGF F FLGF. i39 i342008; 21 (5): 489-498.

20. GG, != 'G, !>= C, = #,G> C, = . A MEF FLJMF-12/23EGFGGF FLGQ GJ L LJLEFL G HKGJKK. Ne3 J M*2007; 356: 580-592.

21. "==>= %J, F IJ, " !, E>= C$, =>= J,%= D, D>= B, G>> , !== A. $FLJMF-17 K JM LJL F M-EF KK. !*38 p4 2009; 30(2): 95-103.

128

CQA#Q *9 .

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129

I#'$D*CI$#A LGL G 370 EGF HGH JGMF L OGJ

J KLEL LG FL OL #B, 170 EGF

OL #C, 15 EGF OL #D F 40 EGF OL

#$. FQ G L GMFLJK L Q HLLK

NJMKK J KG JLJR Q #$ MJF

MK G L KEJ JGMLK G LJFKEKKGF LLN LG F KLEL G 4-5 EGF GFL

FNMK JGMF L OGJ 1, 2, 3, 4. !MJLJ-

EGJ, KLMK OJ GFML GF L JK LGJK

KKGL OL L IMKLGF G HLLK NJMKK

F #$ F GJJ LG LLJ MFJKLF L F H-

LMJ G L JKHLN GFLGFK 5.

FLJGMLGF G L Q LN FLJLJGN-

J LJLEFL (#AA) K F GFLGFK KM

K JGF NJ HLLK F F-KL NJ KK

LG EJ K EGJ L GFJFK. LMK GF-

ML GF L LK G #$ GF HLLK FLGFK

N KGOF LL L JL G HJGJKKGF F GEH-

LGFK JGE NJ HLLK J JL F HLFLK

OL #$ GFLGF 6, 7.

!GJ L HMJHGK G FF KML LJHQ GJ

L EJF L GFJF JHJKFL Q LK

GFLGFK, EGJ F EGJ KLMK J GMKF GFNGHF LJLEFLK F FQRF L K-LK

PL Q L PKLF GFK 8-12.

AGJF LG L KLLKLK HJGN Q L

LGF JGJE G #LJ, GEF K GFK-

J L GMFLJQ OL L KL HJNF G

JGF HLLK C F L MJGHF FGF (4.9%)

F OL GF G L KL HJNF G HLLK B

FLGF (6%) 13.

$F GEF HJGPELNQ 1.5-2 EGF HGH

J FL OL L KL GF LQH G HLLK NJMK

F GFQ 10% J FGK.

AB/AC/

#AA LJHQ K EHJGN PHLFQ FF GF LFQ GFLGFK MK Q L

HLLK NJMKK LL E L F MK G L F #$ FL HLFLK.

$F LK KLMQ JGMH G 300 HLFLK JGE 18 LG 63 QJK OJ KL F GJJ LG KKKK L

HJNF F GFKIMFK G #$ F L HLLK B (#B), C (#C) F D (#D) NJMKK

GFLGFK. LMQ JGMHK OJ KF GJ GFLGF. K JGMHK OJ F LMJF N

F K JGMHK GJE G GFL HJLHFLK F GFLJG JGMHK GFKKLF G EGFG-FL

HJLHFLK.K KKLGF OK GLF Q LKLF L HJLHFLK GJ L HJKF G KH FLGF

EJJK MKF L '$A LFIM. AK JKML, F JJ LG L #$/#B GFLGF L KLMQ

JGMH GFKKL G 16 GFL HJLHFLK F 114 #B-FL HJLHFLK JKMLF F

HJNF G L GFLGF G 14%. $F L K G L #$/#D GFLGF L KLMQ JGMH GF-

KKL G 5 GFL HJLHFLK F 45 #D-FL HJLHFLK. HJNF G L

#$/#C GFLGF OK 25% GML G L 170 #C-FL HJLHFLK.

L G L GFLGFK GF L PHJKKGF F NK G L FLGF EJJK OK FQR

F GFKLJKL LG LGK FGMFLJ F L K G L EGFG-FLGF. GKJN FK F L

PHJKKGF G L KH HLLK EJJK FL L EHL G L GFLGF OL #$ GF L

HJGJKKGF G L HLLK FLGFK. $F LGF, L FIML EEMF JKHGFK LGOJK L

HLLK NJMKK F L K G L GFL HJLHFLK K LG L NGHEFL G JJGKK FF KL NJ KK.

#+A/$/$ B, C A)D D C$)!C/$) $) #$-$)!C/D +A/$)/:

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>: #AA, #$, #B, #C, #D, GFLGF, '$A

*c4*8433 94: BGF $GFKM, -E: [email protected], L.: 0728122746

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130

I$#E(C F "IHQE(C

E K GF L HJKF G KH EJJK GJ

LQH G FLGF 3.

KJFF G L HLLK C FLGF OK G-

MK GF L #CA F F K G HLLK D NJMK,

GF #DA F L #DA LLGF. CGFJFF

L #D, L PKLF G GF G L LOG FNKLLEJJK FKMJ L HJKF G L FLGF.

JGMHK OJ KG LKL GJ L HJKF G

L #$ FLGF GFJE Q L PKLF G

#$A.

B>

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131

H4?088 B, C 0=3 D 2>8=5428>= 8= HI+-8=54243 ?084=: ?40;4=24 0=3 ?>64

HI/HC >=>= HJNF G L #$/ #C GFLGF

EGFKL L 170 #C-FL HJLHFLK OK 24.7%.

EF G L HJLHFLK JKLJ F LK

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42 K JGMH HJLHFLK JKLJ J

NK G #C A GEHJ LG LGK GKJN F

L GFLJG JGMH.

DIC*I$#

#HLLK FLGFK J KEFQ OL #$ GHHGJ-

LMFKL FLGFK, FGMFLJ OL HJN-

F, F F LG JH HJGJKK LG F KL

NJ KK F JJGKK, O LJEF LE LG

GE L EGJ MK G L F #$ FL

HLFLK.

$F LK KLMQ O GKJN L HJGJKK F

LK G L #$-HLLK NJMKK GFLGFK. LMQ

JGMHK OJ KF GJ GFLGF GFKKLF

G K JGMH FMF GFL HJLHFLK F

GFLJG JGMH GJE GML G HJLHFLK KMJF

JGE EGFG-FLGFK OL HLLK NJMKK.

$F L K G L #$- #B L OK GKJN LL

#$ JKK L JF JL G L #BKA F

#BA. J G EEMFGKMHHJKKGF KKGL

OL L #$ FLGF 14 K GFKJ LG JK-

HGFK GJ L QKJMLGF F NJ HLLK EJ-

JK PHJKKGF. LJ KLMK N KGOF LL L

JL G KMJ FLF-FLN ^GML_ #B F-

LGF KEK LG J F L K G #$ GFLHLFLK 15

G L KLMQ JGMHK GJ GFLGF GFKKLF G

EGFG-FL FNMK F JKHLNQ #$ GF-

L FNMK.

JKMLK GLF Q '$A ELG OJ GJ-

JL OL LGK GJ F GLJ KLMK F GJJ LG

KJ F L L LMJK G L GFLGFK.

'E*!

HI/HB >=>= KLMQ JGMH F L K G L #$/#B

GFLGF GFKKL G 16 GFL HJLHFLK F

114 #B-FL HJLHFLK. EF G L

GFL HJLHFLK HJGN LG JGMF 33 QJK.

AK JKML L HJNF G L #$ FLGF EGFKL

L #B KLMQ JGMH OK KKKK LG 14%.

K JGMH PL J JL G #B

EMLHLGF, JL GKK G FL-#BK, J -

NK G #B DA F GOJ A' NK F GEHJ-KGF LG L GFLJG JGMH.

HI/HD >=>= KLMQ G L #$/#D GFLGF OK GF-

ML GF 5 GFL HJLHFLK F 45 #D F-

L HJLHFLK OL EF G 25 QJK.

HJNF G L #D-#$ GFLGF OK LJ-

EF LG 10%.

5 K JGMH HJLHFLK KGO JK

F L #B NJ G F J JL G #KA

JF. A JK F L PHJKKGF G L KMJ

FLF (#BKA) OK KG FGL.

Type of hepatitis B

infectionHBs Ag HBs Ab HBe Ag HBe Ab HBc Ab

Chronic hepatitis B

infectionwith HBe Ag present

+ - + + -

Chronic hepatitis B

infection

without HBe Ag

+ - - + -

Hidden hepatitis B

infection- - + - +

Carriers of the hepatitis B

virus + - + - +

3. C>= > B =>=

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L JJF LG L K JGMHK L GO CD

4 GMFL F LJLGF G QLGFK OL KH-

LQ LGOJK HLLK NJMKK J GFKJ LG

L EGJ MKK G L FIML EEMF JKHGFK

LG L HLLK FLGFK.

GKJN FK F L PHJKKGF G LKH HLLK EJJK FL L EHL G L

GFLGF OL #$ GF L HJGJKKGF G L H-

LLK FLGFK. $F LGF, L FIML EEMF

JKHGFK LGOJK L HLLK NJMKK F L K G

L GFL HJLHFLK K LG L NGHEFL

G JJGKK F F KL NJ KK.

$L K LJGJ G HJEGMFL EHGJLF LL

KML LJHQ K MK F GELF LK EJF

L LJL LG #$ HGKLN HGH. !MJLJEGJ,

EGJ F HL JKJ K JIMJ LG KLK L

HJNF G LK GFLGFK L FLGF KF GJJ LG HJNFL LE JGE JF NF J

NK.

'EFE'E#CE

1. %> ", > C, B=> ', F G *9 . LMJ KLG-JQ G JGF HLLK B F G-FL HLFLK. JH*94 2006;44:65-70.

2. > C. #HLLK B F #MEF $EEMFGFQ JMKCG FLGF. H*94 2009;49:138-145.

3. C= , = C!, > , ! C, != C, CH,GMJ HEGGQ G HLLK D NJMK FLGFEGF FLF JM MKJK OL F OLGML MEFEEMFGFQ NJMK FLGF F OF, J c3M4'4, 2011.

4. H> ! C, CF EHLGFK G #$F HLLK B G-FLGF F AK F AJ, !*l3*9 i3+*948 D8*8*8, 2007, GME 7, $KKM 6,K 402-409.

5. = A , B E CJGF #HLLK B F C:HL GF JHQ, F9* #44>, 2009.

9. = J *9. ., JNF G #HLLK C JMK(#C) $FLGF F #$-HGKLN $FNMK F L -JFK F #C KLF F L $EHL G #C GF #$JLEFL MLGEK,J # H*9, 2010.

10. ' # I, H== J. ., JLEFL G HGHMLGFK L CJGF #HLLK B $FLGF, e=*9r*;*< 4+ G894*39*44> 3 H*944>, 2011.

11. #, != B$, >=> G, H== AB,!= A!, C== %B *9. ., $EHL G HLLK

132

I$#E(C F "IHQE(C

!MJLJEGJ, L FJK JL G #B EMLH-

LGF, JL GKK G FL-#BK, J NK G

#B DA F GOJ A' NK KF F L K G

L GFL HLFLK FL EGJ JH HJGJKK

G L HLLK B FLGF LGOJK F KL NJ

KK. GOJ A' NK KMKL KK HLGQL K-

LJMLGF MK Q L HJKK EEMF JKHGFK

16, 17.

LMK GFML GF L L G #B GF L

#$ HJGJKK N JN F FJK JL G Q

LN FLJLJGNJ LJHQ (#AA)-JL HLG-

LGPLQ, J N G #$ EMLHLGF F

GOJ CD4 GMFL MK Q L HLLK B F-

LGF 18, 19.

HLLK D NJMK K LN NJMK JIM-

JF L HJ MFLGF HJGN Q L HLLK BNJMK F GJJ LG EMLHQ. AK JKML L HLLK DFLGF K FGMFLJ GFQ F HLLK B FL

HJLHFLK. LMK N KGOF LL L #D]#B

GFLGF K KLEL LG GMJ F 5% G L HLFLK

HGKLN GJ #B 5.

K JGMH PL GOJ #B NJ G

F J #BKA JF. GLOGJLQ, L

FLGJQ L PL Q #D GF L DA HGQ-

EJK JKHGFK G L #B EMLHLGF FM-

FK L PHJKKGF G L #B EJJK.

CGFJFF L #$-#C GFLGF L

FJK NK G #C A OJ GKJN F LK JGMH. $F L K G L #C EGFG-FLGF

L EMLHLGF LK H F L HLGQLK ML

L FMEJ G EMLHLGF KLK FJKK OF L

GFLGF K HJKFL. AK JKML #C F EMLHQ

F L QEHG K K O, KM K EJGHK,

CD4 F CD8 QEHGQLK. J JL G EM-

LHLGF K LG EKKN FJK G #C NJ

G GGOF #$ KJGGFNJKGF 18.

MK, L HJGJKK G L HLLK FLGFK

KEK LG HGKLNQ FMF Q L #$ KJG-

GFNJKGF F L FMEJ G EMLHLGFKLK GJ L HLLK C NJMK JHJKFL Q HLG-

QLK F QEHG K KM K EJGHK, CD4

F CD8 QEHGQLK.

LMK GMK GF L L G L #AA LJ-

HQ GF HLLK C HJGJKK N JN F FJK

F L N G NJ FRQEK F HHJGPELQ 30% G

#$-#C GFL FNMK LJ FFF L

LJLEFL. GE FL-#$ JMK KM K FNJHF,

JLGFNJ F KLNMF J EGJ Q LG MK -

NLGFK F NJ FRQEK 19, 20, 21. EGJLQ G

KLMK GFML GF LK GFLGF GFM LL

#$ JLK L HJGJKKGF G #C-JL NJ

KK 21, 22, 23.

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C NJMK GFLGF GF JKHGFK LG Q LN FL-JLJGNJ LJHQ F GMLGE F #$-FL FN-MK: FLGFO GGJL KLMQ, c3 i3+*9 D8, 2006;42(10):1481-7.

12. >= C E, "= J, HEGGQ G #HLLK CJMK $FLGF F #$-$FL $FNMK: JLEFL

G CJGF #HLLK C F #$ GKLN LFLK,J #H*9, 2008.

13. G> !, C E I *9. ., JNF F K!LGJK G #HLLK C JMK $FLGF F AML GHM-LGF F GEF: LGFO MJNQ 2006-2008, JG89439*893 l;* D8, 2010; 373-379.

14. > ", J HLLK F #$ GFLGF, JH*94, 2008; 48(2):353-67.

15. " $ A, FEFL G #$/#B CGFLGF,M*G*3M*, 2006.

16. C " , #MEF $EEMFGFQ JMK (#$)$FLGF, !* M* M3, 2007.

17. C= ' J, JQ QEHLGEL #$ $FLGF,

M*8*, 2010.18. H J, ! !, #$-#B F #$-#C GFLGFF NJ FJ NGHEFL, c3* !*9*39 3r*8*, 2007, 133, 241-252.

19. " , B, '>>, =, , 2009; 29-92; 117-203.

20. B> , ">= , J> B, H A,%> J, B= , "= D, = DH, # A, AGEHJKGF G JK LGJK GJ #C-EGFG-FLGF,#$-EGFG-FLGF, F #C/#$-G-FLGF F GEEMFLQ KLLF, D D8 , p'M*, 2007.

21. B= C, B>=> ", D, #HLLK C F#$/#C CG-FLGF, N49= ", #C/#$ GFLGF, c3 a'8848

p4, 2008.23. !L== D>= C, = A *9 , DFGKK G

#HL !JGKK F CJJGKK Q JFKFL KLGJHQF #$/#HLLK C JMK-CGFL LFLK,J43 4+

a6* i3* D*+*3> >34*8, 2006.

H4?088 B, C 0=3 D 2>8=5428>= 8= HI+-8=54243 ?084=: ?40;4=24 0=3 ?>64

133

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I#'$D*CI$#

FGJE FLKLF EJGGJ (EJGGL)

JHJKFLK GEHP, QFE, F NJK G-

LGF G EJGGJFKEK, O MKMQ FL L

KLJGFLKLF LJL 1. GJEQ, LOF LK GJ

F L MEF GKL EMLMQ F GF-LJE

KQEGL JLGFKH K KLK 2, OJ L

GKL GFLJMLK KKFL FMLJFLK FKKJQ GJ L

KMJNN G L EJGGL F L LLJ MK EML-

H JGK F GKL FMLJLGF F NGHEFL.

NJ NEFLK N JFLQ GFNJ

LG JFO FLJKL F KLMQF L FGJE ML EJG-

GL: L NGHEFL G EGMJ ELGK G

KLMQF L EJG GEEMFLK, L EHJGN

MFJKLFF G GKL-EJG FLJLGFK F L

F KK, F L HGLFL GJ LJHML EF-

HMLGF G L EJGGL 3.

JG G FLKLF EJGGJ F L F

KK K GEF FJKFQ JGFR.

GEHGKLGF F LNLK G L "$ EJGGJ F

N F, ML KG JEM GMLGEK GF L

GKL.

"$!EC*!A' ECH#$!$GIE $F *DI#GHE "IC'$BI$A

F EGKL LJ KHK FFGL MLMJ,

GNJ L HKL 10 QJK KGHKLL bMLMJ FHF-

FL_ ELGK N F NGH 4. GKL G

LE N KG J LJL L KE KMMFL () 16

JGKGE A (JA) F KIMFK (JGE EH-

LJ FM PLJL JGE K GJ

GHKK), GFLFF JGFK G GL Q GFKJ-

N F QHJNJ FMGL KIMFK 5. 16

JA FQKK F GFQ HHJK L HQGFL

GEHGKLGF G KEH F HJGN FG JL FGJ-

ELGF GML LK MFLGF HLK 6. N-

LQ G LJ KIMF L K LL L

NGHEFL G EGMJ HJGK GJ NJGMK KGHK-

LL ELGK ( 1) 7-9.

LFGE FQKK JGFKLJML L FLJ -

FGE G L EJG GEEMFLQ, F GJJ LG LJ-

EF LK GEHGFFL EJG FK F FK (L

^EJGGE_). AGJF LG LK HHJG, MEFK

J LMQ bKMHJGJFKEK_, OGK FGE K L

KME G FK G LJ GOF FGE F G L EJG-

AB/AC/

FGJE FLKLF EJGGJ (EJGGL) JHJKFLK GEHP, QFE, F NJK GLGF G

EJGGJFKEK, O MKMQ FL L KLJGFLKLF LJL. GJEQ, LOF LK GJ F L MEF

GKL EMLMQ F GF-LJE KQEGL JLGFKH K KLK, OJ L GKL GFLJMLK KKF-

L FMLJFLK FKKJQ GJ L KMJNN G L EJGGL F L LLJ MK EMLH JGK F GKL FMLJLGF

F NGHEFL. NJ NEFLK N JFLQ GFNJ LG JFO FLJKL F KLMQF L FGJE

ML EJGGL: L NGHEFL G EGMJ ELGK G KLMQF L EJG GEEMFLK, L EHJGN

MFJKLFF G GKL-EJG FLJLGFK F L F KK, F L HGLFL GJ LJHML EFHM-

LGF G L EJGGL. HJKFL JFL L GFJFF L EGMJ LFGGK G KLMQF LEJGGL F FO FFK JJF L GEHGKLGF G L FGJE GJ. MFJF L F

LNLK G L ML GJ GF L MEF GKL. EHKR L JFL FFK F L LJLGFK G L EJG-

GL F NJGMK E GFLGFK ( KK, JJL GO KQFJGE, GKLQ, GGJL FJ,

J KGJJK, F KHQ FEELGJQ GO KKK). JKMLK G LK FO KLMK KMKL LL

FK G L EJGGL GM F LG L LGHLGFKK G LK KKK. K GMLKLFF

FFK GM MK GJ MJLJ FGKL LGGK F/GJ LJHQ.

/# "/ ($CB$/A $) /# (/A")($C A:

(/$( A !$)D, (/$( A !

D0=84;0 E;4=0 U40=*

Ci H&*& "*789> 4+ M*)(* &) p&7&(> c/-N&54(&, r4&&

>: ML EJGGL, ELFGEK, ELGGEK, FEELGJQ GO KK, KK, JJLGO KQFJGE, GGJL FJ, J KGJJK

*c4*8433 94: DF F eJF, ^$MM #cFM_ FNJKLQ G F F JEQ CM-HG, GEF, GFLJ CF, LJ. CJfF FJ. 5, CM-HG, GEF; : 40-264-532216, -E: [email protected]

134

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135

GE 10. !MFLGF ^GE_ ELGK KLMQ L

GEEMFLQaK PHJKK A (EL-LJFKJHLGEK),

HJGLF HJGMLK (EL-HJGLGEK), F LK ELG

FLOGJ (EL-ELGGEK) 10. K HHJG

GOK L LLGF G L KLJMLMJK F MFLGFK G

EJG GEEMFLK, K O K LJ FLJLGFKOL L LLK LQ GMHQ. LFGE F E-

LGGE HJGF G L EJGGL, LGM L F

JQ KL, N EGFKLJL L JF F GE-

HPLQ G L ML GKQKLE F KL FKLK FLG

KNJ KKK 11.

HGJLK GF L KKKKEFL G L ML EJGGL

N LG JMQ NML, K GF L KLMQ

KF F HGHMLGF KR, K O K F L JE G

NFLK F ELLGFK G L LFGGK F L

KL GFJF - MEF GJ KMJ-JFL GJ 8.

C$"%$II$# $F HE G* "IC'$F!$'A

#MEF ML GFLFK 10 LEK EGJ LJ

(1014) LF MJQGL K F L FLJ MEF GQ

12. K ML GJ K JGMF 100 LEK K EFQ

FK F JL K LJ J F L MEF FGE

13. A NJQ GEHP ELFGE KLMQ KGO F

J 2010 LL ML EJGGJ GEHJKK 1000-1500

KHK F FNM K L KL 160 KM KH-

K, O J KG JQ KJ. NJ 99% G L

FK J LJ, L JEFJ F EGKLQ

J, OL GFQ 0.1% G MJQGL F NJ GJ-FK. Q KG N KGOF L PKLF G GE-

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MLK, 30.6-83% (CGKLJME, MEFGGMK, ML-

JME, DGJ, HLGKLJHLGGMK, HLGGMK, '-

LGMK); BLJGLK, 8-48% (BLJGK); A-

LFGLJ, 0.7-16.7% (BGLJME) F JG-LGLJ, 0.1-26.6% (FLJGLJ) 8, 14.

EGKL GEEGF FJ G MF FM CF

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LJ JF 1010-1012/ G MEF GFLFL).

I"%$'A#CE $F HE G* F!$'A $# HEH*"A# H$

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FGJF KQKLE) 15. JGGL ELK EFQ

Q MFLGFK, KGE G LE FGL F LG

N Q L ML LKKM GF 3. ELG

LNLQ G L EJGGJ K GFKJ LG IM LG

LL G L NJ 16.

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KLN FRQE LNLQ, EMK O LFKK, G-

QLGF HJGMLGF, EGLLQ K O K KEJ

QJaK HLK, OJ FLJHL QEHGQLK,

GOJ KJME EEMFGGMF NK. CGFNJKQ,

LK JE-J FEK N EGJ FLJGJGEF

K, FLGF F KLJKK-KMKHLLQ, K O K

JIMJEFL G GJ FL 4.

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LGJF 4

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HJGLF JEFLLGF OL HJGMLGF G EFG K

FKHFK LG MEFK 18; NLEF KQFLKK -

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GKL G MFLGFK G ML GJ J N

LJGM C!AK 4: H# GOJF (JMF L GJE-LGF G KGFJQ JQ K - HJG-JFGFK F

JMF L GMFLK G EF LJ); FJKF

ML KGJHLGF G OLJ; FMLJFL GJ JGOL G GE-

EFK LJ; FJKF JGOL G MEF ML K

(HL F QEHG K); GF KGJLGF 15.

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$F FGFLK, KLLGF , EG G NJQ, F NF LJ G ELJF GJF, KF-

LJQ GFLGFK, GJH KLJMLGF G LJ

KHK, ELJF LJQ FL, F QaK L J

)74 6 8>0 8= 74

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EHGJLFL LGJK. MEJGMK KLMK N GMF

HJGEFF G 'LG (') F BGLJME

(B!), JKHLNQ EGJ NJK GJ, FMF B-

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NFL G HJGGL F/GJ HJGL-FJ GJEM-

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EM.

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KLGF G EJG ML GEEMFLK: , KP, L,

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FGJF MFLGFK, F FL JGMF), L-

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6, 19.

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LOF GJ F GKL F JGF: JEM HJG-

HJLK G KGE GEHGFFLK G L EJGGJ 12,

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L F FL-L GJFKEK (QKGKK), F HJ-

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FF, L KGG-GFGE NGHEFL K LG

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KGE G LE N LJEFL LK GF L GKLL (L QF QHGLKK) 9. JGMK KKK,

JGE FLGFK, LG FJLN, FEELGJQ,

EEMF, F J KGJJK EQ HHJ 1. JQ

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K GPQLG, EGF KHH, CF FK),

F KHKK, Q EJGK LJFKGLGF 5. J AEH-

F GJ GLJ FFK KMHHJKK L FGJE JG

F FJG GJ (FMF ', B!, LJHLGGMK),

OL FJK G K, JGLMK F CF.

ALJ MKF AEGPF, L KLGG GJ JKK L

EGKL GF L 4L Q F JLMJFK L FGJE NK GF

L 30L Q, F EGKL G KK 20.

I B> =>

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ME KLGQLME, CGKLJME LMKMJFK F

!LJME HJMKFLR JGMH HJGHGJLGFK OJ

KK MFFL F MFLJL CD HLFLK LF F #C.

F L GFLJJQ, BLJGK-JNGL JGMH HJG-

HGJLGFK OJ FJK F MFLJL CD HLFLK NK

#C. 'NK G $A GLF L BLJGK-JNGL

JGMH OJ KFFLQ JM F GL CD H-

LFLK NK #C 28. AFGLJ KLMQ K LL F MF-

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(KJ G F BLJGK JGMHK) F HGLF-

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FFK F JF L FGKK NK GF MLF JL NK #C N F JFLQ HMK. BLJGK

F CGKLJME HLME JGMHK OJ EGJ MFFL

F K F GHKK G CD JF NK #C, JJ-

KK G L KL G CD. AKG, L NK G K-

J G F LHQGGMK GMFLK F K F

GHKK G FGF-LJL CD HLFLK OJ J

LF F #C, ML LJ NK FGJER LJ MLF-

J L. B! NK OJ JM F K G GL

JGMHK G CD HLFLK F F GHKK G MFLJL

CD HLFLK NK #C 30.

C>> C= (C'C)JQ KLMK N KGOF LL BLJGK F

CGKLJME FJK L LMEGMJ JL, OJK KGE

KLJFK G ' F B! EQ FL GGF LMEGMJ N-

GHEFL 15. $F JLF KLMLGFK, GEEFK L-

J GM M L HJGJKKGF LGOJK GGJL E-

FFQ Q FJLF JLN ELGLK, GFNJL-

F HJG-JFGFK LG JFGFK, LJF GKL J-

GQJL PHJKKGF, FJLGF G LGP HJGMLK G

L HJGLF ELGKE 2, 3, 15.

$F NJQ JFL KJK, L MLGJK GEHJ KLGG

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F #C 31. AFGLJ FLJKLF HHJ JN LL

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HJKKGF F HJGMLGF J KFFLQ FJK F

FGEK, O FGE EMGK KGO FJ-

K FLLJ LNLQ 3 ;94 GEHJ OL FGJ-

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K 6 F 12 EGFLK LF JF OG E GNJ-

OL/GK 35. K JKMLK KMKL LL JF-

K F L EJGGL HJ GNJOL/GKLQ.

A (D

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LGF G GLJK JLFQ KMKLF L JLGF GJ LJ-

HML EFHMLGF G FLJ LJ MKF HJ-

EGLK.

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: 465-72.6. %. 2010; 156: 3205]15.22. C>= C, $S">= !, == F, & E",

" J'. A EGMJ FQKK G F EMG-K LJ GEEMFLK F JJL GO KQFJGE.D D8 . 2010; 55: 392]7.

23. 'W->=>W ", B E, H HG, . "GF H EGMJ FQKK G EJGGL KFLMJKF KEHK JGE HLFLK OL JJL GO KQF-JGE. G894*39*44>. 2011 AM 4. HM GHJFL

24. == A, >- !, ">> H, . EJGGL G JJL GO KQFJGE H-LFLK JK KFFLQ JGE LL G LQ KMLK.

G894*39*44>. 2007; 133: 24-33.25. = C, *== C, C ",= . H MGF F LJ JGMHKKKGL OL HLJ G KK. J c3p94. 2009; 62: 264-9.

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2011; 6: 16393.32. %== C, C>> D, "=>= "!, . ALJLGF

G G EJGGJ F a-FKFK QHJ-HJGMLGF FGGF FGE EMGK.J c3 G894*39*4. 2011;45: 602-10.

33. = %J, B F, F>= !, G>>= JI. DL-FM GKLQ K F LG EJ ML JNJK LJ-LGF

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