« selection » d’actualités en onco-radiothérapie

GR DIG 2020

Disclosure 1

• Cette selection est (très) arbitraire!

Plan

• Cancer du rectum

Plan

• Cancer du rectum• Cellules Myeloides

Myeloid compartment?

A link between OS and neutrophilia?

Schernberg Acta oncol 2017

Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO‐04 randomized phase 3 rectal cancer trial

International Journal of Cancer, Volume: 145, Issue: 8, Pages: 2282-2291, First published: 14 March 2019, DOI: (10.1002/ijc.32274)

Plan

• Cancer du rectum• Cellules Myeloides• Canal anal

Determination of predictive models basedon multi modal imaging (PET, MRI, CT)

Plan cancer Physicancer 2017, FRM2017 PRTK2020

Imaging of inflammation

Radiother Oncol 2017 (X2)EJC 2017Oncotarget 2016 &2017Acta Oncol 2017EJNMI 2017

Plan

• Cancer du rectum• Cellules Myeloides• Canal anal• immuno

Role of the cGAS–STING pathway in antitumor immunity

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing, Chen et al. Nature Immunology 2016

Is it really the STING you need?

Vanpouille-Box, Nat Comm. 2017