« selection » d’actualités en onco-radiothérapie
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« selection » d’actualités en onco-radiothérapie GR DIG 2020
Transcript of « selection » d’actualités en onco-radiothérapie
« selection » d’actualités en onco-radiothérapie
GR DIG 2020
Disclosure 1
• Cette selection est (très) arbitraire!
Plan
• Cancer du rectum
Plan
• Cancer du rectum• Cellules Myeloides
Myeloid compartment?
A link between OS and neutrophilia?
Schernberg Acta oncol 2017
Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO‐04 randomized phase 3 rectal cancer trial
International Journal of Cancer, Volume: 145, Issue: 8, Pages: 2282-2291, First published: 14 March 2019, DOI: (10.1002/ijc.32274)
Plan
• Cancer du rectum• Cellules Myeloides• Canal anal
Determination of predictive models basedon multi modal imaging (PET, MRI, CT)
Plan cancer Physicancer 2017, FRM2017 PRTK2020
Imaging of inflammation
Radiother Oncol 2017 (X2)EJC 2017Oncotarget 2016 &2017Acta Oncol 2017EJNMI 2017
Plan
• Cancer du rectum• Cellules Myeloides• Canal anal• immuno
Role of the cGAS–STING pathway in antitumor immunity
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing, Chen et al. Nature Immunology 2016
Is it really the STING you need?
Vanpouille-Box, Nat Comm. 2017
