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Degradative analytical tools for large moleculesDiagnosis of tuberculosis and aging of oil paintingsPacheco Botelho Mourão, M.
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Citation for published version (APA):Pacheco Botelho Mourão, M. (2018). Degradative analytical tools for large molecules: Diagnosis of tuberculosisand aging of oil paintings.
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Download date: 13 Dec 2020
Degradative Analytical Tools for Large
Molecules: Diagnosis of Tuberculosis and
Aging of Oil Paintings
Marta Pacheco Botelho Mourão
Degradative Analytical Tools for Large Molecules: Diagnosis of Tuberculosis and Aging of Oil Paintings PhDthesis,UniversityofAmsterdam,TheNetherlandsPublishedby:Proefschriftmaken//www.proefschriftmaken.nlThisworkwasfinanciallysupportedbytheUBSOptimusFoundationandNanoNextNL,amicroandnanotechnologyconsortiumoftheGovernmentoftheNetherlandsand130partners.Author:MartaPachecoBotelhoMourãoISBN:978-94-93019-17-1
Degradative Analytical Tools for Large
Molecules: Diagnosis of Tuberculosis and
Aging of Oil Paintings
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor promoties
ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 12 oktober 2018, te 12:00 uur
door
Marta Pacheco Botelho Mourão
geboren te Lissabon, Portugal
Promotiecommissie: Promotores: Prof. Dr. Ir. J.G.M. Janssen Universiteit van Amsterdam Prof. Dr. Ir. P.J. Schoenmakers Universiteit van Amsterdam Copromotores: Dr. A.H.J. Kolk Universiteit van Amsterdam Dr. W.T. Kok Universiteit van Amsterdam Overige leden: Prof. Dr. Ing. M.R. van Bommel Universiteit van Amsterdam
Prof. Dr. P.D. Iedema Universiteit van Amsterdam Prof. Dr. R.A.H. Peters Universiteit van Amsterdam Dr. M. Camenzuli Universiteit van Amsterdam Dr. J.M Florência Nogueira Universidade de Lisboa Prof. Dr. G.W. Somsen
Vrije Universiteit Amsterdam Faculteit der Natuurwetenschappen, Wiskunde en Informatica
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Table of contents 1.GeneralIntroduction..................................................................................91.1 Chromatography:historyandtechniques......................................................101.2 Developmentsinthediagnosisoftuberculosis............................................111.3 Developmentsinoil-basedpaintingsinartsciences.................................121.4 Scopeofthethesis.....................................................................................................13References.........................................................................................................................15-17
2.Hyphenationofcapillarygaschromatographywithmassspectrometry:generalprinciplesandhistory.....................................192.1 Introduction.................................................................................................................202.2 GCfundamentalsintheperspectiveofhyphenationandspeedofanalysis......................................................................................................................................222.3 InstrumentalfactorsofMS....................................................................................382.4 RecentdevelopmentsinsamplepreparationforGC-MS..........................532.5 Applications,miniaturizationandfutureofhyphenatedGC-MS..........64References.........................................................................................................................67-70
3.DirectdetectionofMycobacteriumtuberculosisinsputumusingsolid-phaseextraction-gaschromatography-massspectrometry:methoddevelopmentandvalidation......................................................713.1 Introduction.................................................................................................................723.2 Materialsandmethods............................................................................................743.3 Resultsanddiscussion.............................................................................................783.4 Conclusions...................................................................................................................84References.........................................................................................................................84-86Appendix...................................................................................................................................87Appendix3.1............................................................................................................................87
4.Hyphenatedandcomprehensiveliquidchromatography×gaschromatographyfortheidentificationofMycobacteriumtuberculosis......................................................................................................894.1 Introduction.................................................................................................................914.2 Materialsandmethods............................................................................................934.3 Resultsanddiscussion.............................................................................................984.4 Conclusions................................................................................................................1104.5 Supplementaryinformation...............................................................................110References....................................................................................................................111-114
5.Strategiestowardsasimplerchromatographicmethodforsputum-baseddiagnosisoftuberculosis.............................................1155.1 Introduction..............................................................................................................1165.2 Materialsandmethods.........................................................................................118
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5.3 Resultsanddiscussion..........................................................................................1245.4 Conclusions................................................................................................................1455.5 Futureperspectives...............................................................................................1465.6 Acknowledgments..................................................................................................1505.7 Supplementaryinformation...............................................................................151References....................................................................................................................154-158
6.Applicationofpolyurethane-baseddevicesassorption-desorptionphasesformicroextractionanalysis..............................1596.1 Introduction..............................................................................................................1616.2 Materialsandmethods.........................................................................................1636.3 Resultsanddiscussion..........................................................................................1676.4 Conclusions................................................................................................................1796.5 Acknowledgements................................................................................................180References....................................................................................................................181-182
7.Elucidatingthestructureofpolymerizedlinseedoil-AMethylLinoleatemodel...........................................................................................1837.1 Introduction..............................................................................................................1847.2 Materialsandmethods.........................................................................................1887.3 Resultsanddiscussion..........................................................................................1917.4 Conclusions................................................................................................................2127.5 Acknowledgements................................................................................................213References....................................................................................................................213-216
8.Chromatography-baseddevicesforstudyingtheChemistryofLight-InducedDegradation(COLD)-Afeasibilitystudy................2178.1 Introduction..............................................................................................................2188.2 Materialsandmethods.........................................................................................2208.3 Resultsanddiscussion..........................................................................................2228.4 Conclusionsandrecommendations................................................................2328.5Acknowledgements................................................................................................233References....................................................................................................................233-236
Listofabbreviations..........................................................................237-238Summary...............................................................................................239-243Samenvatting.......................................................................................243-247Listofpublications.....................................................................................248Overviewofauthors’contributions.............................................249-252Acknowledgements…………………………………………………………...253-254
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