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Degradative analytical tools for large moleculesDiagnosis of tuberculosis and aging of oil paintingsPacheco Botelho Mourão, M.

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Citation for published version (APA):Pacheco Botelho Mourão, M. (2018). Degradative analytical tools for large molecules: Diagnosis of tuberculosisand aging of oil paintings.

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Download date: 13 Dec 2020

Degradative Analytical Tools for Large

Molecules: Diagnosis of Tuberculosis and

Aging of Oil Paintings

Marta Pacheco Botelho Mourão

Degradative Analytical Tools for Large Molecules: Diagnosis of Tuberculosis and Aging of Oil Paintings PhDthesis,UniversityofAmsterdam,TheNetherlandsPublishedby:Proefschriftmaken//www.proefschriftmaken.nlThisworkwasfinanciallysupportedbytheUBSOptimusFoundationandNanoNextNL,amicroandnanotechnologyconsortiumoftheGovernmentoftheNetherlandsand130partners.Author:MartaPachecoBotelhoMourãoISBN:978-94-93019-17-1

Degradative Analytical Tools for Large

Molecules: Diagnosis of Tuberculosis and

Aging of Oil Paintings

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor promoties

ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel

op vrijdag 12 oktober 2018, te 12:00 uur

door

Marta Pacheco Botelho Mourão

geboren te Lissabon, Portugal

Promotiecommissie: Promotores: Prof. Dr. Ir. J.G.M. Janssen Universiteit van Amsterdam Prof. Dr. Ir. P.J. Schoenmakers Universiteit van Amsterdam Copromotores: Dr. A.H.J. Kolk Universiteit van Amsterdam Dr. W.T. Kok Universiteit van Amsterdam Overige leden: Prof. Dr. Ing. M.R. van Bommel Universiteit van Amsterdam

Prof. Dr. P.D. Iedema Universiteit van Amsterdam Prof. Dr. R.A.H. Peters Universiteit van Amsterdam Dr. M. Camenzuli Universiteit van Amsterdam Dr. J.M Florência Nogueira Universidade de Lisboa Prof. Dr. G.W. Somsen

Vrije Universiteit Amsterdam Faculteit der Natuurwetenschappen, Wiskunde en Informatica

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Table of contents 1.GeneralIntroduction..................................................................................91.1 Chromatography:historyandtechniques......................................................101.2 Developmentsinthediagnosisoftuberculosis............................................111.3 Developmentsinoil-basedpaintingsinartsciences.................................121.4 Scopeofthethesis.....................................................................................................13References.........................................................................................................................15-17

2.Hyphenationofcapillarygaschromatographywithmassspectrometry:generalprinciplesandhistory.....................................192.1 Introduction.................................................................................................................202.2 GCfundamentalsintheperspectiveofhyphenationandspeedofanalysis......................................................................................................................................222.3 InstrumentalfactorsofMS....................................................................................382.4 RecentdevelopmentsinsamplepreparationforGC-MS..........................532.5 Applications,miniaturizationandfutureofhyphenatedGC-MS..........64References.........................................................................................................................67-70

3.DirectdetectionofMycobacteriumtuberculosisinsputumusingsolid-phaseextraction-gaschromatography-massspectrometry:methoddevelopmentandvalidation......................................................713.1 Introduction.................................................................................................................723.2 Materialsandmethods............................................................................................743.3 Resultsanddiscussion.............................................................................................783.4 Conclusions...................................................................................................................84References.........................................................................................................................84-86Appendix...................................................................................................................................87Appendix3.1............................................................................................................................87

4.Hyphenatedandcomprehensiveliquidchromatography×gaschromatographyfortheidentificationofMycobacteriumtuberculosis......................................................................................................894.1 Introduction.................................................................................................................914.2 Materialsandmethods............................................................................................934.3 Resultsanddiscussion.............................................................................................984.4 Conclusions................................................................................................................1104.5 Supplementaryinformation...............................................................................110References....................................................................................................................111-114

5.Strategiestowardsasimplerchromatographicmethodforsputum-baseddiagnosisoftuberculosis.............................................1155.1 Introduction..............................................................................................................1165.2 Materialsandmethods.........................................................................................118

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5.3 Resultsanddiscussion..........................................................................................1245.4 Conclusions................................................................................................................1455.5 Futureperspectives...............................................................................................1465.6 Acknowledgments..................................................................................................1505.7 Supplementaryinformation...............................................................................151References....................................................................................................................154-158

6.Applicationofpolyurethane-baseddevicesassorption-desorptionphasesformicroextractionanalysis..............................1596.1 Introduction..............................................................................................................1616.2 Materialsandmethods.........................................................................................1636.3 Resultsanddiscussion..........................................................................................1676.4 Conclusions................................................................................................................1796.5 Acknowledgements................................................................................................180References....................................................................................................................181-182

7.Elucidatingthestructureofpolymerizedlinseedoil-AMethylLinoleatemodel...........................................................................................1837.1 Introduction..............................................................................................................1847.2 Materialsandmethods.........................................................................................1887.3 Resultsanddiscussion..........................................................................................1917.4 Conclusions................................................................................................................2127.5 Acknowledgements................................................................................................213References....................................................................................................................213-216

8.Chromatography-baseddevicesforstudyingtheChemistryofLight-InducedDegradation(COLD)-Afeasibilitystudy................2178.1 Introduction..............................................................................................................2188.2 Materialsandmethods.........................................................................................2208.3 Resultsanddiscussion..........................................................................................2228.4 Conclusionsandrecommendations................................................................2328.5Acknowledgements................................................................................................233References....................................................................................................................233-236

Listofabbreviations..........................................................................237-238Summary...............................................................................................239-243Samenvatting.......................................................................................243-247Listofpublications.....................................................................................248Overviewofauthors’contributions.............................................249-252Acknowledgements…………………………………………………………...253-254