Suggestions For Peri-Procedural Management Of EdoxabanPublished on Anticoagulation Services(https://depts.washington.edu/anticoag/home)

Suggestions For Peri-Procedural Management Of Edoxaban .CrCl T 1/2 Time of last dose of edoxaban prior to

procedure

(peri-procedural bridging is generally notrequired)

Standard Risk ofBleeding

High Risk ofBleeding1

(major surgery, spinal puncture or placement of spinal/epiduralcatheter, and other situations in which complete hemostasis is

required

1ASRA 4th edition 2018: hold 72 hours for all patients prior toneuraxial procedures, without regard for influence of renal function

on half-life and clearance

80-95 ml/min 10-14 hrs at least 24 hours at least 48 hours50-79 ml/min 10-14 hrs30-49 ml/min 10-14 hrs 15-29 ml/min 17 hrs at least 48 hours at least 72 hours< 15 ml/min unknown edoxaban assay is currently unavailable at

UWMedicine to determine absence of drug effect

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