Membrane Separation
Process
Background of Membrane separation
technology
• Simple filtration technology which can separate
molecules according to their molecular size
• No heat treatment→ Low Initial Cost, Small Energy, → Low Initial Cost, Small Energy,
High Quality of Products
Name of membranes Molecular weight
Pore size
Permeate flux of water at 38 bar,24°С (LMH)
Å Ångström nanometer
UM 05UM 2UM 10
5001 000
10 000
212430
2.12.43.0
1734
102UM 10PM 10PM 30XM 50XM 100AXM 300
10 00010 00030 00050 000
100 000300 000
30384766
110480
3.03.84.76.6
11.048.0
102935850425
11052215
Objective of the Work
Development of a membrane separation
process which can efficiently purify anserine-process which can efficiently purify anserine-
carnosine (AC) extracted from chicken meat
Materials
(preparation of chicken extract)
Chicken carcass
Extraction
Water
water:carcasses=3:1
100˚C, 4-6 h
Ion exchange resin
NF membrane
Removal AC: 6.25 g/L (235)
Creatinine: 2.31 g/L (113)
Na+: 0.27 g/L (56)Acidic and neutral
amino acids
Apparatus
Lab-Module type 20.(DSS)
Maximum membrane area:
7200 cm2 (180 cm2×40 sheets)Maximum pressure: 6 MPaMaximum pressure: 6 MPa
Maximum temperature: 100˚C
pH-range: 0-14
Membranes used in this study
MembraneNaCl rejection(*MW cut-off)
Manufacturer Material
NFT50 55 DSS Polypiperazine /polyamide/
DRA4510 45 DAISEN Polyamide
Desal DL 15 Desalination Polyamide (aromatic)
Desal DK 50 Desalination Polyamide (aromatic)
NTR7430 30 NITTO DENKO Sulfonated polyether sulfone
NTR7450 50 NITTO DENKO Sulfonated polyether sulfone
NTR7250 60 NITTO DENKO Polyvinyl alcohol
MPF34 35 Abcor Polysulfone
MPF36 10 Abcor Polysulfone
MPF44 25 Abcor Polyacrylonitrile (PAN)
MPF50 700* Abcor Polyacrylonitrile (PAN)
G-5 1000* Desalination Polyamide
G-10 2500* Desalination Polyamide
Total Circulation Experiment
Feed
PI
Ret
enta
te
F
I
PI
Feed flow rate: 5.8 - 11.3 L/minPressure: 1 - 6 MPaTemperature: 25 ˚C
FeedRet
enta
te
Permeate
Pump
Feed tank
Batch Wise Experiment
Permeate
Ret
enta
te PI
FI
PI
Creatinine and Sodium Ion
Area of membrane: 360 cm2
Temperature: 25 ˚CInitial weight of Feed: 11.2 kgFinal weight of Feed: 3 kg
Ret
enta
te
Feed
Pump
Feed tank
Analyses and Calculation of Rejection Value
� HPLC using column (TSKG2, 500PWXl) with 45% acetonitrile (pH3.0).
� ICP-AES (JICP-PS3000UV; Leeman Lab).
.. b C� .. b
Robs: Observed rejectionCp: Concentration of permeateCr: Concentration of retentate
r
p
obsC
CR −=1
Results of Total circulation experiment
Effect of operating pressure (�P) on permeate flux (Jv) and
observed rejection for anserine-carnosine (RAC), creatinine (RCr)
and sodium ion (RNa) with NFT50 membrane
Results of Total circulation experiment
Effect of flow rate on permeate flux (Jv) and observed
rejection for anserine-carnosine (RAC), creatinine (RCr) and
sodium ion (RNa) with NFT50 membrane
Result of total circulation experiment
Membrane Jv x106 [m3/(m2 s)] RAC RCr RNa
NFT50 61.1 0.998 0.765 0.811
DRA4510 54.9 0.994 0.813 0.835
Desal DK 42.4 0.992 0.713 0.733
Desal DL 36.8 0.997 0.439 0.446
MPF36 34.7 0.751 0.490 0.257MPF36 34.7 0.751 0.490 0.257
NTR7250 29.2 0.888 0.564 0.234
MPF50 28.5 0.017 0.035 -
NTR7430 27.8 0.925 0.600 0.719
NTR7450 13.9 0.941 0.704 0.842
MPF34 11.8 1.000 0.990 0.980
G-10 8.8 0.453 0.214 0.588
MPF44 6.3 0.940 0.886 0.757
G-5 4.6 0.406 0.070 0.593
Results (Batch-Wise Concentration)
Changes in purity, yield, concentration of anserine-carnosine and
permeate flux value (Jv) during Batch wise experiment with NFT50
membrane (flow rate:10 L/min, pressure:4 MPa)
Proposal of a Mathematical Model
A: membrane area
Jv: Permeate flux
V: volume of solution
t: time
C: concentration of components)1(
)(ACacv
fACRCJA
dt
VCd−−=
ρv
JAdt
dV−= (1)
(2)
C: concentration of components
R: rejection of components
CF: concentration factor
D: constant
k: mass transfer coefficient
dt
)ln(CFkDJv −=
fV
VCF 0=
(3)
(4)
Simulation Results
Changes in purity, yield, concentration (CAC) of anserine-carnosine
and permeate flux value (Jv) with NFT50 membrane (experimental
value and calculation line)
Process design
Chicken carcass
Extraction
Ion exchange resin
5 t/d
4-6 h
RemovalEluted solution 1,400 kg
Water 15 t
Extract 15,000 kg
NF membrane
Anserine-Carnosine
Creatinine and sodium ion
Acidic and neutral
amino acids NFT50 membrane
1.2 m2, 6 hPermeate
Eluted solution 1,400 kg
Retentate: 150 kg
(conc.: 7.5%, purity: 90%, yield: 98%, AC: 11.2 kg)
Whey
Purification /centryfuge and cake filter/
UF membraneRetentate
Permeate
Permeate
3 kind of UF
membrane
Curd and
Retentate
NF membrane
Lactulose
Solvent
Solvent protein’s 3 kind of NF
membranePermeate
RetentatePermeate
Retentate
(purity: 90%, yield: 95%)
membrane
Thank you very much for
your kind attention
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