VII. Pathophysiology
Modifiable
Lifestyle
SMOKING
Non- Modifiable
Age
Decrease secretion of
HCO3 from the pancreas
Increase secretion of HCL
& pepsin from the
pancreas into the
gastrodoudenal.
Increase concentration /
activity of the acid-pepsin
Decrease interference
with HCL secretion from
the pancreas into
duodenum
Mucosal damaged occurs
Duodenal mucosa cannot withstand
the digestive action of the HCL and
pepsin
Damaged mucosa cannot
secrete enough mucus to
act as a barrier against HCL
Duodenal Ulcer
Decrease resistance of
mucosa
Destruction of blood vessels
Further mucosal erosion Increase acid in duodenum, Erodes the lesions and stimulates the exposed nerve
endings.
Bile / pancreatic enzymes
reflux from duodenum
Abdominal pain Mucosal bleeding
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