VII. Pathophysiology

Modifiable

Lifestyle

SMOKING

Non- Modifiable

Age

Decrease secretion of

HCO3 from the pancreas

Increase secretion of HCL

& pepsin from the

pancreas into the

gastrodoudenal.

Increase concentration /

activity of the acid-pepsin

Decrease interference

with HCL secretion from

the pancreas into

duodenum

Mucosal damaged occurs

Duodenal mucosa cannot withstand

the digestive action of the HCL and

pepsin

Damaged mucosa cannot

secrete enough mucus to

act as a barrier against HCL

Duodenal Ulcer

Decrease resistance of

mucosa

Destruction of blood vessels

Further mucosal erosion Increase acid in duodenum, Erodes the lesions and stimulates the exposed nerve

endings.

Bile / pancreatic enzymes

reflux from duodenum

Abdominal pain Mucosal bleeding