• Opportunistic pathogen

• Commensal organism

Candida albicans

superficial and systemic infections~ 10,000 deaths per year in U.S.A.

Cell Morphologies of C. albicans

Hyphae

PseudohyphaeYeast

Environmental Control of Morphogenesis

Serum, 37o CpH > 7Starvation

Yeast Pseudohyphae/hyphae

YPD or YNB medium30o C

Yeast Cell Division Cycle

Actin Cables and Actin Patches

Yeast Cell Division Cycle

Environmental Control of Morphogenesis

Serum, 37o CpH > 7Starvation

Yeast Pseudohyphae/hyphae

YPD or YNB medium30o C

Light Microscope

Hyphal Formation in Candida albicans

Light Microscopy Fluorescence Microscopy ofHWP1-GFP gene