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ARTICLE IN PRESSJHH 32 1–2

rev bras hematol hemoter. 2 0 1 4;x x x(x x):xxx–xxx

Revista Brasileira de Hematologia e HemoterapiaBrazilian Journal of Hematology and Hemotherapy

www.rbhh.org

mages in Clinical Hematology

ycobacterium leprae in bone marrow

eonardo Rodrigues de Oliveira ∗, André Luiz Maltos

niversidade Federal do Triângulo Mineiro – UFTM, Uberaba, MG, Brazil

r t i c l e i n f o

rticle history:

eceived 4 March 2014

ccepted 17 March 2014

vailable online xxx

he case of a 54-year-old man, who was referred to eval-ate a consumptive syndrome with anemia and fever ofnknown origin, is reported. A physical examination revealedadarosis, nodular lesions on the ears, nasal soft tissue

ollapse, subcutaneous nodules on arms and generalizedymphadenopathy. Laboratory tests showed anemia (Hb.8 g/dL, mean corpuscular volume 82.4 fL, mean corpuscularemoglobin 24.5 pg), normal reticulocyte count (0.5%), throm-ocytosis (482 × 109 L–1), normal serum ferritin (268 ng/mL)nd elevated C-reactive protein (124 mg/L). Serologies (viralepatitis and human immunodeficiency virus) were non-eagent. Lepromatous leprosy was confirmed by staining forcid-fast bacilli using samples from the ear and subcutaneousodules and bone marrow smears. Bone marrow was hyper-ellular with myeloid hyperplasia (myeloid–erythroid ratio:1) but without dysplasia. Mycobacterium leprae was detected

Please cite this article in press as: de Oliveira LR, Maltos AL. Mycobahttp://dx.doi.org/10.1016/j.bjhh.2014.05.010

ying free and in foamy histiocytes named Virchow cellsFigs. 1 and 2).1,2 A multidrug therapeutic regimen (clofaz-mine, dapsone, rifampicin) was established with progressivemprovement.

∗ Corresponding author at: Universidade Federal do Triângulo Mineiro –25 Uberaba, MG, Brazil.

E-mail address: leonardorodoli@hotmail.com (L.R. de Oliveira).

Fig. 1 – Large cells (histiocytes) with their abundantcytoplasm filled with acid-fast bacilli (Mycobacterium leprae)in bone marrow (Ziehl-Neelsen stain) magnification 1000×.

ttp://dx.doi.org/10.1016/j.bjhh.2014.05.010516-8484/© 2014 Associacão Brasileira de Hematologia, Hemoterapiaeserved.

BJHH 32 1–2cterium leprae in bone marrow. Rev Bras Hematol Hemoter. 2014.

UFTM, Central de Quimioterapia, Rua Getúlio Guarita, s/n, 38080-

e Terapia Celular. Published by Elsevier Editora Ltda. All rights

ARTICLE IN PRESSBJHH 32 1–2

2 rev bras hematol hemoter. 2

Fig. 2 – Large cells (histiocytes) with their abundantcytoplasm filled with acid-fast bacilli (Mycobacterium leprae)in bone marrow (Fite-Faraco stain) magnification 1000×.

r

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Cytopathology. 2006;17:257–61.2. Suster S, Cabello-Inchausti B, Robinson MJ.

Non-granulomatous involvement of the bone marrow inlepromatous leprosy. Am J Clin Pathol. 1989;92:797–801.

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Please cite this article in press as: de Oliveira LR, Maltos AL. Mycobahttp://dx.doi.org/10.1016/j.bjhh.2014.05.010

0 1 4;x x x(x x):xxx–xxx

Conflicts of interest

The authors declare no conflicts of interest.

e f e r e n c e s

. Singh N, Bhatia A, Lakra A, Arora VK, Bhattacharya SN.Comparative cytomorphology of skin, lymph node, liver andbone marrow in patients with lepromatous leprosy.

BJHH 32 1–2cterium leprae in bone marrow. Rev Bras Hematol Hemoter. 2014.