Mycobacterium leprae in bone marrow
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Transcript of Mycobacterium leprae in bone marrow
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ARTICLE IN PRESSJHH 32 1–2
rev bras hematol hemoter. 2 0 1 4;x x x(x x):xxx–xxx
Revista Brasileira de Hematologia e HemoterapiaBrazilian Journal of Hematology and Hemotherapy
www.rbhh.org
mages in Clinical Hematology
ycobacterium leprae in bone marrow
eonardo Rodrigues de Oliveira ∗, André Luiz Maltos
niversidade Federal do Triângulo Mineiro – UFTM, Uberaba, MG, Brazil
r t i c l e i n f o
rticle history:
eceived 4 March 2014
ccepted 17 March 2014
vailable online xxx
he case of a 54-year-old man, who was referred to eval-ate a consumptive syndrome with anemia and fever ofnknown origin, is reported. A physical examination revealedadarosis, nodular lesions on the ears, nasal soft tissue
ollapse, subcutaneous nodules on arms and generalizedymphadenopathy. Laboratory tests showed anemia (Hb.8 g/dL, mean corpuscular volume 82.4 fL, mean corpuscularemoglobin 24.5 pg), normal reticulocyte count (0.5%), throm-ocytosis (482 × 109 L–1), normal serum ferritin (268 ng/mL)nd elevated C-reactive protein (124 mg/L). Serologies (viralepatitis and human immunodeficiency virus) were non-eagent. Lepromatous leprosy was confirmed by staining forcid-fast bacilli using samples from the ear and subcutaneousodules and bone marrow smears. Bone marrow was hyper-ellular with myeloid hyperplasia (myeloid–erythroid ratio:1) but without dysplasia. Mycobacterium leprae was detected
Please cite this article in press as: de Oliveira LR, Maltos AL. Mycobahttp://dx.doi.org/10.1016/j.bjhh.2014.05.010
ying free and in foamy histiocytes named Virchow cellsFigs. 1 and 2).1,2 A multidrug therapeutic regimen (clofaz-mine, dapsone, rifampicin) was established with progressivemprovement.
∗ Corresponding author at: Universidade Federal do Triângulo Mineiro –25 Uberaba, MG, Brazil.
E-mail address: [email protected] (L.R. de Oliveira).
Fig. 1 – Large cells (histiocytes) with their abundantcytoplasm filled with acid-fast bacilli (Mycobacterium leprae)in bone marrow (Ziehl-Neelsen stain) magnification 1000×.
ttp://dx.doi.org/10.1016/j.bjhh.2014.05.010516-8484/© 2014 Associacão Brasileira de Hematologia, Hemoterapiaeserved.
BJHH 32 1–2cterium leprae in bone marrow. Rev Bras Hematol Hemoter. 2014.
UFTM, Central de Quimioterapia, Rua Getúlio Guarita, s/n, 38080-
e Terapia Celular. Published by Elsevier Editora Ltda. All rights
ARTICLE IN PRESSBJHH 32 1–2
2 rev bras hematol hemoter. 2
Fig. 2 – Large cells (histiocytes) with their abundantcytoplasm filled with acid-fast bacilli (Mycobacterium leprae)in bone marrow (Fite-Faraco stain) magnification 1000×.
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Cytopathology. 2006;17:257–61.2. Suster S, Cabello-Inchausti B, Robinson MJ.
Non-granulomatous involvement of the bone marrow inlepromatous leprosy. Am J Clin Pathol. 1989;92:797–801.
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Please cite this article in press as: de Oliveira LR, Maltos AL. Mycobahttp://dx.doi.org/10.1016/j.bjhh.2014.05.010
0 1 4;x x x(x x):xxx–xxx
Conflicts of interest
The authors declare no conflicts of interest.
e f e r e n c e s
. Singh N, Bhatia A, Lakra A, Arora VK, Bhattacharya SN.Comparative cytomorphology of skin, lymph node, liver andbone marrow in patients with lepromatous leprosy.
BJHH 32 1–2cterium leprae in bone marrow. Rev Bras Hematol Hemoter. 2014.