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3. design: annette fenner & nicola hawes Cover image:
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Based on an engraving by Peter Paul Rubens (1638) from
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Nature Reviews Cardiology S1 acute coronary syndromes | Walking the
tightrope between efficacy and bleeding Payal Kohli and Christopher
P. Cannon S3 atrial fibrillation | Stroke prevention in AF Gregory
Y. H. Lip S5 heart failure | Heart failure therapytechnology to the
fore John J. V. McMurray S7 hypertension | New insightsfrom risk
factors to treatment implications George L. Bakris S9 valvular
disease | Breakthrough for intervention? Volkmar Falk Nature
Reviews Clinical Oncology S11 ovarian cancer | Mutations and
non-inferiority analyses show a way forward Maurie Markman S12
prostate cancer | Hitting old targets better and identifying new
targets Yu Chen and Howard I. Scher S14 hematological cancer | New
therapeutic targets and treatment strategies Paula Cramer and
Michael Hallek S16 melanoma | A new paradigm tumor for drug
development Alexander M. M. Eggermont and Caroline Robert S18 bone
cancer | Prevention and treatment of bone metastases Robert E.
Coleman
4. Nature Reviews Endocrinology Nature Reviews Neurology S21
thyroid disease in pregnancy | Thyroid functioneffects on mother
and baby unraveled Anthony P. Weetman S55 stroke | Major advances
across the spectrum of stroke care Lee H. Schwamm S22 primary
aldosteronism | Towards a better understanding of causation and
consequences Michael Stowasser S24 polycystic ovary syndrome |
Genes, aging and sleep apnea in polycystic ovary syndrome Andrea
Dunaif S26 epigenetics and metabolism | Epigenetics, the
life-course and metabolic disease Peter D. Gluckman S28
osteoporosis | Osteoporosis therapydawn of the postbisphosphonate
era Roland Baron S57 movement disorders | Translating new research
findings into clinical practice Christine Klein and Dimitri Krainc
S58 multiple sclerosis | Advances in therapy, imaging and risk
factors in MS Bianca Weinstock-Guttman and Murali Ramanathan S60
dementia | Microbleeds in dementiasinging a different ARIA Philip
Scheltens and Jeroen D. C. Goos S62 epilepsy | Insights into
epilepsy treatments and biomarkers Fernando Cendes S30 type 1
diabetes mellitus | Heterogeneity of T1DM raises questions for
therapy Paolo Pozzilli Nature Reviews Gastroenterology &
Hepatology Nature Reviews Rheumatology S33 hepatitis c | A new
standard of care and the race towards IFN-free therapy Wolf Peter
Hofmann and Stefan Zeuzem S65 rheumatoid arthritis | Advances in
diagnosis, treatment and definition of remission Gerd R. Burmester
S35 hepatocellular carcinoma | Genomics in hepatocellular
carcinomaa big step forward Ryosuke Tateishi and Masao Omata S67
juvenile idiopathic arthritis | New takes on categorization and
treatment Alberto Martini S36 ibd | Advances in IBD
managementtowards a tailored approach Guillame P. Pineton de
Chambrun and William J. Sandborn S68 systemic lupus erythematosus |
Deciphering the role of NETs and networks in SLE Thomas Drner S38
the gut microbiota | Translating the microbiota to medicine Fergus
Shanahan S40 neurogastroenterology | Emerging concepts in
neurogastroenterology and motility Keith A. Sharkey and Gary M.
Mawe S70 osteoarthritis | Age-related OAa concept emerging from
infancy? Thomas Aigner and Wiltrud Richter S72 systemic sclerosis |
From mechanisms to medicines Luc Mouthon S74 vasculitis | The
renaissance of granulomatous inflammation in AAV Stephan D. Gadola
and Wolfgang L. Gross Nature Reviews Nephrology Nature Reviews
Urology S43 glomerular disease | New clues to environmental
influences in glomerular disease Peter J. Nelson and Charles E.
Alpers S77 prostate cancer | Redefining the therapeutic landscape
for CRPC Carmel Pezaro and Gerhardt Attard S44 polycystic kidney
disease | Connecting the dots toward a polycystic kidney disease
therapy Vicente E. Torres and Peter C. Harris S79 bladder cancer |
The dawn of personalized medicine Thomas W. Flaig and Dan
Theodorescu S46 acute kidney injury | Biomarkers are transforming
our understanding of AKI Lakhmir S. Chawla and John A. Kellum S48
nondialysis chronic kidney disease | Progression, prediction,
populations and possibilities Adeera Levin S50 dialysis | Can
cardiovascular risk in dialysis patients be decreased? Peter
Stenvinkel and Peter Brny S52 transplantation | New agents, new
ideas and new hope Titte R. Srinivas and Bruce Kaplan S80 sexual
dysfunction | Advances in epidemiology, pathophysiology and
treatment Eric Chung and Gerald B. Brock S82 male factor
infertility | Semen quality, sperm selection and hematospermia
Amichai Kilchevsky and Stanton Honig S84 kidney cancer |
Objectifying risk for localized renal masses Marc C. Smaldone and
Robert G. Uzzo
5. CARDIOLOGY ACUTE CORONARY SYNDROMES IN 2011 Walking the
tightrope between efficacy and bleeding Payal Kohli and Christopher
P .Cannon Major advances in the diagnosis of acute coronary
syndromes (ACS) have occurred in 2011, but physicians treating ACS
still walk the tightrope between efficacy and bleeding. Key
publications have shed light on this delicate balance and heralded
a new era of novel oral anticoagulants for the treatment of ACS.
Kohli, P & Cannon, C.P Nat. Rev. Cardiol. 9, 6971 (2012);
published online 20 December 2011; doi:10.1038/nrcardio.2011.206 .
. The year 2011 has witnessed an evolution in all aspects of the
management of acute coronary syndromes (ACS). The intro uction of d
new-generation troponin assays has compli cated the diagnostic
dilemma in ACS by increasing the number false positive diagnoses.
One of the most-interesting studies of 2011 addressed whether the
reduced threshold for detection of myocardial injury translated
into improved clinical outcomes. Mills etal. undertook a
prospective study of >1,000 patients who presented with possible
ACS before and after the introduction of a lower diagnostic
threshold (from 0.20ng/ml to 0.05ng/ml) for myocardial infarction
(MI) using a high-sensitivity troponin assay with a low coefficient
of variability (