It’s all about ATP

How do you get it?

PMF

ATP synthesisusing the PMFis ancient

Cytosolic enzymes convert glucose to pyruvate

The ante is 2 ATP but you get 4 if you win

Plus reducing power (that’s where it’s at)

(and we’re not even in the mitochondrion yet)

In the cytosol

Still in the cytosol

OK, back to the mitochondrion

porin

Cardiolipin,76% protein

The BIG picture

Coupled to e- transport

2C +4C

6C

Reducing power with carbon loss

Free lunch

5C

4C

KrebTricarboxylicCitric acidCycle

Harnessing the reducing power

Converting the redox potentialinto the PMF

2 will get you 4: the Q cycle

Coupled to e- transport

5C

4C

Remember this step?

matrix

Down to water

Now, drive ATP with the PMF