It’s all about ATP. How do you get it? PMF ATP synthesis using the PMF is ancient.
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Transcript of It’s all about ATP. How do you get it? PMF ATP synthesis using the PMF is ancient.
It’s all about ATP
How do you get it?
PMF
ATP synthesisusing the PMFis ancient
Cytosolic enzymes convert glucose to pyruvate
The ante is 2 ATP but you get 4 if you win
Plus reducing power (that’s where it’s at)
(and we’re not even in the mitochondrion yet)
In the cytosol
Still in the cytosol
OK, back to the mitochondrion
porin
Cardiolipin,76% protein
The BIG picture
Coupled to e- transport
2C +4C
6C
Reducing power with carbon loss
Free lunch
5C
4C
KrebTricarboxylicCitric acidCycle
Harnessing the reducing power
Converting the redox potentialinto the PMF
2 will get you 4: the Q cycle
Coupled to e- transport
5C
4C
Remember this step?
matrix
Down to water
Now, drive ATP with the PMF
