Choosing the path of least resistanceHot Melt Extrusion vs. Spray Drying

© 2014 Hovione

Hot Melt Extrusion Spray Drying

Solubilization and Stability

Challenges

Dru

g L

oad

ing

(%

)

Drug Melting Point (ºC)

100

0

25

50

75

100

150 200 250 300

No dependence on

organic solubility

Max

imum

Org

anic

So

lub

ility

(%

)

Drug Melting Point (ºC)

100

0

5

10

15

20

150 200 250 300

Commercial Feasibility

Decreases

Max

imum

Org

anic

So

lub

ility

(%

)

Drug Melting Point (ºC)

100

0

5

10

15

20

150 200 250 300

No drug loading or melting

point limitations related to process

Dru

g L

oad

ing

(%

)

Drug Melting Point (ºC)

100

0

25

50

75

100

150 200 250 300