Hot Melt Extrusion vs. Spray Drying Choosing the path of ... · Choosing the path of least...
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Choosing the path of least resistance Hot Melt Extrusion vs. Spray Drying © 2014 Hovione Hot Melt Extrusion Spray Drying Solubilization and Stability Challenges Drug Loading (%) Drug Melting Point (ºC) 100 0 25 50 75 100 150 200 250 300 No dependence on organic solubility Maximum Organic Solubility (%) Drug Melting Point (ºC) 100 0 5 10 15 20 150 200 250 300 Commercial Feasibility Decreases Maximum Organic Solubility (%) Drug Melting Point (ºC) 100 0 5 10 15 20 150 200 250 300 No drug loading or melting point limitations related to process Drug Loading (%) Drug Melting Point (ºC) 100 0 25 50 75 100 150 200 250 300
Transcript of Hot Melt Extrusion vs. Spray Drying Choosing the path of ... · Choosing the path of least...
Choosing the path of least resistanceHot Melt Extrusion vs. Spray Drying
© 2014 Hovione
Hot Melt Extrusion Spray Drying
Solubilization and Stability
Challenges
Dru
g L
oad
ing
(%
)
Drug Melting Point (ºC)
100
0
25
50
75
100
150 200 250 300
No dependence on
organic solubility
Max
imum
Org
anic
So
lub
ility
(%
)
Drug Melting Point (ºC)
100
0
5
10
15
20
150 200 250 300
Commercial Feasibility
Decreases
Max
imum
Org
anic
So
lub
ility
(%
)
Drug Melting Point (ºC)
100
0
5
10
15
20
150 200 250 300
No drug loading or melting
point limitations related to process
Dru
g L
oad
ing
(%
)
Drug Melting Point (ºC)
100
0
25
50
75
100
150 200 250 300