HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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Hoover City Schools Secondary Curriculum Science, 2006-07
Course Information:
Course Title: Genetics and Biotechnology Grade Level: 11 – 12
Course Description: This course includes the study of the biotechnology techniques used in CSI labs to amplify DNA samples, identify paternity and identity, in addition to conducting techniques used in cloning. Discover the molecular basis of cancer and the mind boggling similarities and differences in humanities appearance and behavior. Explore other topics such as immunology, population and behavioral genetics. Students will engage in multifaceted explorations and investigations from extracting their very own DNA to cloning plants to making bacteria glow in the dark!
State COS Correlate: Genetics Elective Core Calendar Type: Year
Pre-requisite: Chemistry Co-requisite: None
Textbook Title: Human Genetics- Concepts and Applications Textbook Publisher: McGraw Hill
Textbook ISBN: 007305061X Textbook Copy Year: 2007, 7th ed
Accountability Standards: None LEA Curriculum Authors: J. Carden
Date of LEA Approval: Spring 2006
Topical Scope and Sequence:
Unit # 1st Nine Weeks
1 What is Genetics and Biotechnology
Mitosis, The Cell Cycle and Cancer
2 Meiosis and Cytogenetics
3 Gene Transmission – Mendelian Genetics
4 Gene Transmission- Modifications of Mendelian Genetics
Unit # 2nd
Nine Weeks
5 Genetic Recombination and Mapping
6 Structure and Function of DNA/RNA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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Unit # 2nd
Nine Weeks
7 Gene Expression
8 Gene Regulation
Unit # 3rd
Nine Weeks
9 Mutation and Genetic Variation
10 Construction and Analysis of Clones
11 Applications of Biotechnology
Unit # 4th
Nine Weeks
12 Immunology
13 Population Genetics
14 Behavioral Genetics
Units and Outcome-Based Objectives:
Unit 1- Introduction to Genetics, Mitosis The Cell Cycle and Cancer
Essential Questions:
What is the historical impact of genetics on society?
Why is this important to the present and the future of the field of genetics?
What is the connection between the cell cycle and cancer?
Conceptual Connections:
History
Ethics
Health
Experimental Activities:
# Unit 1 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 DNA Extraction 1.5 Inquiry
2 Mitosis Lab 1.2 Experiment
Outcome-Based Objectives:
# Unit 1 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Discuss the historical impact of genetics
on society. Introductory 3 NA
2 Describe the role of mitotic divisions
during growth and repair. Mastery 4 NA
3 Explore the role of the cell cycle as the Mastery 4 NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 1 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
underlying cause of cancer.
4 Define genetics and biotechnology. Mastery 3 NA
5
Apply prior knowledge of cell structure
and chemistry to conduct a DNA
extraction.
Introductory NA NA
6 Learn laboratory safety and proper use
of laboratory equipment. Mastery NA NA
Unit 2- Meiosis and Cytogenetics
Essential Questions:
What is the purpose of meiosis?
What may occur as a result of errors in meiosis?
What is cytogenetics?
What is genetic counseling?
Conceptual Connections:
Ethics
Society and Technology
Experimental Activities:
# Unit 2 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Hela Splat 2.3 Experiment
2 Case Study 2.8 Experiment
Outcome-Based Objectives:
# Unit 2 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Describe the role of meiotic divisions in
reproduction. Mastery 4 NA
2 Understand how meiotic errors result in
abnormal phenotypes. Introductory 4 NA
3
Conduct a HeLa splat and study the
further processes required to create a
karyotype.
Introductory 9 NA
4
Look at modern methods for karyotype
analysis and conduct a computer
analysis to diagnose case studies.
Introductory 9 NA
5 Explore the causes and effects of
polyploidy, aneuploidy, and euploidy. Introductory 9 NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 2 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
6 Become familiar with prenatal diagnosis
and testing. Introductory 9 NA
7 Discuss ethical implications of prenatal
testing. Introductory 9 NA
8 Analyze a case study as a genetic
counselor. Introductory 9 NA
9 Compare and contrast spermatogenesis
and oogenesis. Mastery 9 NA
Unit 3- Gene Transmission – Mendelian Genetics
Essential Questions:
What is the chromosome theory of inheritance?
What problem solving techniques are used in transmission genetics?
Why is understanding Mendel’s principles important in genetics today?
What is pedigree analysis?
How is pedigree analysis utilizied?
Conceptual Connections:
History
Problem Solving
Experimental Activities:
# Unit 3 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Measuring and Pipetting 3.9 Experiment
2 Gel Electrophoresis Basics 3.9 Experiments
3 Chi- Square 3.5 Inquiry
Outcome-Based Objectives:
# Unit 3 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Conduct monohybrid crosses. Mastery 3 NA
2 Understand the principle of segregation. Mastery 3 NA
3 Understand and apply the concepts of
dominance and recessiveness. Mastery 3 NA
4 Conduct dihybrid crosses. Mastery 3 NA
5 Understand the principle of independent
assortment. Mastery 3 NA
6 Conduct fork-line method crosses. Introductory 5b NA
7 Conduct Chi-Square analysis. Introductory NA NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 3 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
8
Learn the genetic and molecular basis of
inherited disorders and the patterns in
which they are inherited.
Introductory 5a NA
9 Look at pedigree construction as a basic
method for studying human genetics. Introductory 5a NA
10 Recognize patterns of inheritance for
given pedigrees. Introductory 5a NA
11 Conduct basic techniques of molecular
biology. Mastery 9 NA
Unit 4- Gene Transmission – Modifications of Mendelian Genetics
Essential Questions:
What are two variations of Mendelian inheritance?
How may an individual’s sex influence inheritance and phenotype?
How many factors other than genotype affect phenotypic expression?
How do twins help us to understand heritability?
What do obesity, skin color and fingerprints have in common?
How do you lift and analyze fingerprints?
Conceptual Connections:
Biotechnology and Society
Forensics
Diversity
Experimental Activities:
# Unit 4 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Basic Aseptic Technique 4.9 Experiment
2 Fingerprinting Lab 4.4 Inquiry
3 Blood Typing Investigation 4.3 Experiment
Outcome-Based Objectives:
# Unit 4 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Identify incomplete dominance,
codominance and multiple alleles. Mastery 5b NA
2 Describe occurrences and effects of sex
linkage. Introductory 6 NA
3 Describe occurrences and effects of
autosomal linkages, crossover, multiple Introductory 6 NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 4 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
alleles and polygenes.
4 Describe how environment influences
phenotypic expression. Introductory NA NA
5 Define heritability. Mastery NA NA
6 Conduct basic techniques of
biotechnology. Mastery 9 NA
Unit 5- Genetic Recombination and Mapping
Essential Questions:
What is meant by genetic recombination?
What is gene linkage?
How does crossing over allow us to map genes?
Why is bacterium vital to the study of genetics?
What is transformation and how is it utilized in biotechnology today?
Conceptual Connections:
Biotechnology and Society
Experimental Activities:
# Unit 5 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Gram Staining 5.4 Experiment
2 Transformation of E.Coli with pGlo 5.7 Experiment
3 Protein chromatography of pGlo 5.7 Experiment
Outcome-Based Objectives:
# Unit 5 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Explain gene linkage. Introductory 6 NA
2 Define genetic recombination. Introductory NA NA
3 Apply the principle of recombination
frequency to gene mapping. Introductory NA NA
4 Compare and contrast the types of
bacteria. Mastery NA NA
5 Define the role of bacterial structures. Mastery NA NA
6 Describe bacterial reproduction. Mastery NA NA
7 Explore the role of bacteria in
biotechnology today. Introductory NA NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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Unit 6- Structure and Function of DNA/RNA
Essential Questions:
What is the chemical composition and structure of DNA and RNA ?
How is DNA organized?
What is the mechanism for replication?
What is PCR and how is it utilized in forensic investigations?
Conceptual Connections:
Structure and Function
Organization
Technology and Society
Experimental Activities:
# Unit 6 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 DNA Structure 6.1 Experiment
2 Polymerase Chain Reaction 6.4
6.5 Experiment
Outcome-Based Objectives:
# Unit 6 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Identify the structure and function of
DNA and RNA. Mastery
7
7c NA
2 Explain the structure of eukaryotic
chromosomes. Mastery 8 NA
3 Describe the mechanism for DNA
replication. Introductory 7 NA
4 Describe techniques used for PCR. Introductory 9 NA
5 Identify applications of PCR in
biotechnology. Introductory 9 NA
Unit 7- Gene Expression
Essential Questions:
How are genes organized?
What is The Central Dogma?
What is the genetic code?
What are the mechanisms for transcription and translation?
Conceptual Connections:
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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Organization
Form and function
Experimental Activities:
# Unit 7 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Genetic Code Exploration 7.2 Inquiry
2 Gene Expression Investigation
7.2
7.3
7.4
Experiment
Outcome-Based Objectives:
# Unit 7 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Explain the structure of a gene including
transposons, introns and exons. Mastery 8 NA
2 Apply the genetic code to predict amino
acid sequence. Mastery 7a NA
3 Define the role of RNA in protein
synthesis. Mastery 7c NA
4 Describe the mechanisms for
transcription and translation. Introductory 7 NA
Unit 8- Gene Regulation
Essential Questions:
How are genes regulated?
What are proteins?
What roles do proteins have in the cell?
What are metabolic pathways?
What is the relationship between amino acid mutations, enzyme defects and
phenotypic effects?
What are pharmacogenetics and ecogenetics?
Conceptual Connections:
Form and Function
Organization
Health
Experimental Activities:
# Unit 8 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 8 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Protein Structure Investigation 8.2
8.3 Experiment
2 Metabolic Disorders Research 8.5 Project
Outcome-Based Objectives:
# Unit 8 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Describe the methods cells use to
regulate gene expression. Introductory 7b
AHSGE:
x-n
2 Explain the levels of protein structure. Introductory NA NA
3 Explain the relationship between protein
structure and function. Introductory NA NA
4
Identify significant contributions of
biotechnology in agricultural and
medical practices.
Introductory 9 NA
5 Describe the effects of amino acid
mutation on phenotype. Introductory 2 NA
Unit 9- Mutation and Genetic Variation
Essential Questions:
What is a mutation?
What factors cause mutation?
What is the molecular basis of mutations
How are mutations detected?
Conceptual Connections:
Diversity
Health
Experimental Activities:
# Unit 9 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Mutation Investigation 9.1 Inquiry
2 Mutation Exercise 9.4 Experiment
Outcome-Based Objectives:
# Unit 9 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Describe factors such as radiation, Introductory 2 NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 9 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
chemicals, and chance that cause
mutations in a population.
2 Describe effects of genetic variability on
adaptations. Introductory 2 NA
3 Describe techniques used to detect
mutations. Introductory 2 NA
4 Describe the role of mutation in cancer. Introductory 2 NA
Unit 10- Construction and Analysis of Clones
Essential Questions:
What are clones?
What are the methods of clone production?
What are the techniques used in cloning?
What is a genetic library?
How are clones characterized?
Conceptual Connections:
Biotechnology and society
Ethics
Experimental Activities:
# Unit 10 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Cloning Technique
10.1
10.2
10.3
Experiment
2 Plant Cloning 10.1
10.4 Experiment
3 Sequencing 10.1
10.4 Experiment
4 Southern Blotting 10.4 Experiment
5 Restriction Mapping 10.4 Experiment
6 DNA Databases 10.5
10.6 Virtual Lab
Outcome-Based Objectives:
# Unit 10 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Describe techniques used with
recombinant DNA. Introductory 9a NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 10 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
2 Define a clone. Mastery 9a NA
3 Describe methods of cloning. Introductory 9a NA
4 Describe and conduct techniques for
clone characterization. Introductory 9a NA
5 Access and utilize genetic libraries. Introductory 9a NA
6 Utilize active databanks such as NCBI. Introductory 9a NA
Unit 11- Applications of Biotechnology
Essential Questions:
How have recombinant DNA techniques revolutionized genetic mapping?
What are the applications of DNA fingerprinting?
What are DNA chips?
What is the Human Genome Project?
What are the applications of the Human Genome Project?
What ethical issues surround these most recent advances in biotechnology?
Conceptual Connections:
Bioinformatics
Forensics
Biotechnology and Society
Experimental Activities:
# Unit 11 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 DNA chips 11.3 Virtual lab
2 Gene therapy 11.4 Virtual Lab
3 Molecular Forensics 11.3 Virtual Lab
4 Paternity Lab
11.1
11.2
11.4
Experiment
Outcome-Based Objectives:
# Unit 11 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Define RFLPs and VNTRs and how
they are produced. Introductory 10 NA
2 Explore how RFLPs are utilized. Introductory 10 NA
3
Explain how and why the following
applications are performed:
Prenatal testing, DNA fingerprinting.
Introductory 10 NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 11 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
4
Explore the commercial and medical
applications of biotechnology including
bio-pharming, gene therapy, crop and
livestock breeding.
Introductory 10 NA
5 Differentiate among major areas of
biotechnology. Introductory 10 NA
6 Discuss ethical issues raised by
recombinant DNA technology. Introductory
10
P-2 NA
7 Explain the development and purpose of
the Human Genome Project. Introductory 10 NA
8
Analyze results of the Human Genome
Project to predict ethical, social, and
legal implications.
Introductory 10 NA
Unit 12- Viruses and The Immune System
Essential Questions:
How does the immune system protect the body?
What is the immune response?
What is the role of the immune system in transplantation?
Why do we have allergies?
What are viruses and how do they attack the immune system?
What is HIV?
What is epidemiology?
Conceptual Connections:
Health
Form and Function
Biotechnology and society
Experimental Activities:
# Unit 12 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Xenotransplantation 12.4 Project
2 Epidemiology 12.8 Inquiry
3 ELISA Assay 12.9 Virtual Lab
Outcome-Based Objectives:
# Unit 12 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Describe the inflammatory response and
the complement system. Introductory NA NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 12 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
2
Explain the mechanism of antibody
formation including the genetic
recombination involved in generating
distinctive antibodies.
Introductory 10b NA
3 Differentiate between antibody-
mediated and cell mediated responses. Introductory NA NA
4
Apply knowledge of importance of
genetics and the immune system in
transplants to the concept of
xenotransplantation.
Introductory 10b NA
5 Explore autoimmune diseases and
allergies. Introductory NA NA
6
Describe the replication of DNA and
RNA viruses, including the lytic and
lysogenic cycles.
Mastery 11 NA
7 Explore viruses and their role in the
immune system. Introductory 11 NA
8 Conduct an epidemiological case study
of transmission. Introductory 10b NA
9 Explore diagnostic testing. Introductory 10b NA
Unit 13- Population Genetics
Essential Questions:
What factors contribute to the diversity of a population?
What is the Hardy-Weinberg principle?
Conceptual Connections:
Diversity
Evolution
Experimental Activities:
# Unit 13 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Hardy-Weinberg
13.2
13.3
13.4
Experiment
2 Population Genetics 13.1
13.4 Experiment
Outcome-Based Objectives:
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 13 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1 Conduct a class population study. Introductory 1 NA
2 Define the variables associated with the
Hardy-Weinberg association. Mastery 1 NA
3
Apply the Hardy-Weinberg Law to the
study of frequency of alleles within this
“population”.
Introductory 1 NA
4
Explain how Hardy-Weinberg principle
provides a baseline for recognizing
evolutionary changes in gene frequency
due to genetic drift, gene flow,
nonrandom mating, mutation and natural
selection.
Introductory 1 NA
Unit 14- Behavioral Genetics
Essential Questions:
What is behavior?
What methods are utilized for studying behavior?
What molecular mechanisms may bring about behavioral alterations?
Conceptual Connections:
Psychology
Health
Ethics
Experimental Activities:
# Unit 14 Investigations Unit Obj
Correlation Type
(Dem, Exp, Inq)
1 Behavioral Survey 14.1 Project
2 Fruit Fly Behavior Study 14.5 Virtual Lab
Outcome-Based Objectives:
# Unit 14 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
1
Comprehend that most behavioral traits
represent complex phenotypes with
mulitfactorial inheritance.
Introductory
5
6
NA
2 Explore the range of methods utilized
for studying human behavior. Introductory 9 NA
3 Explain that single gene defects can
bring about altered behavior in humans. Introductory 2 NA
4 Understand the complex nature of Introductory 6 NA
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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# Unit 14 Objectives Mastery Level
(Int, Rev, Mas)
COS
Alignment
Accountability
Alignment
behavioral traits.
5
Propose possible results or outcomes of
future events based on observations and
inferences drawn from previous events.
Introductory P-5 NA
Alabama Course of Study Correlation: Science
COS Title Genetics Elective Core Bulletin 2005, No. 20
Std.
# COS Standard
HCS Unit-
Objective
CONTENT STANDARDS
1
Explain how the Hardy-Weinberg principle provides a baseline for
recognizing evolutionary changes in gene frequency due to genetic
drift, gene flow, nonrandom mating, mutation, and natural
selection.
13.1
13.2
13.3
13.4
2
Describe factors such as radiation, chemicals, and chance that
cause mutations in populations. 9.1
a) Describing effects of genetic variability on adaptations 9.2
3
Describe the significance of Mendel’s work to the development of
the modern science of genetics, including the laws of segregation
and independent assortment.
1.1
3.1
3.2
3.3
4
Describe the process of meiosis and the cell cycle and the
hereditary significance of each.
1.1
1.2
2.1
2.2
2.3
2.4
2.5
a) Comparing spermatogenesis and oogenesis using charts 2.9
5
Describe inheritance patterns based on gene interactions.
3.6
3.7
3.8
4.1
a) Predicting patterns of heredity using pedigree analysis
3.6
3.7
3.8
b) Identifying incomplete dominance, codominance, and
multiple allelism 4.1
6 Describe occurrences and effects of sex linkage, autosomal
linkage, crossover, multiple alleles, and polygenes.
4.2
4.3
4.4
7 Describe the structure and function of DNA, including replication, 6.1
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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COS Title Genetics Elective Core Bulletin 2005, No. 20
Std.
# COS Standard
HCS Unit-
Objective
translation, and transcription. 6.3
7.3
7.4
a) Applying the genetic code to predict amino acid sequence
7.2
7.3
7.4
b) Describing methods cells use to regulate gene expression 8.1
c) Defining the role of RNA in protein synthesis 7.3
8 Explain the structure of eukaryotic chromosomes, including
transposons, introns, and exons. 7.1
9
Differentiate among major areas in modern biotechnology,
including plant, animal, microbial, forensic, and marine.
(Examples: hybridization, cloning, insulin production, DNA
profiling, bioremediation)
8.4
10.1
10.2
10.3
10.4
10.5
a) Describing techniques used with recombinant DNA
(Examples: DNA sequencing, isolation of DNA segments,
polymerase chain reaction, gel electrophoresis)
8.4
10.1
10.2
10.3
10.4
10.5
10
Explain the development and purpose of the Human Genome
Project.
11.1
11.2
11.3
11.4
11.5
11.6
11.7
11.8
11.9
a) Analyzing results of the Human Genome Project to predict
ethical, social, and legal implications
12.2
12.4
12.8
12.9
b) Describing medical uses of gene therapy, including
vaccines and tissue and antibody engineering
12.2
12.4
12.8
12.9
11 Describe the replication of DNA and RNA viruses, including lytic
and lysogenic cycles, using diagrams.
12.6
12.7
PROCESS AND APPLICATION STANDARDS
P-1 Observing: Using one or more of the senses to gather information 1.1
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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COS Title Genetics Elective Core Bulletin 2005, No. 20
Std.
# COS Standard
HCS Unit-
Objective
about one’s environment 1.2
P-2 Communicating: Conveying oral or written information verbally
as well as visually through models, tables, charts, and graphs 5.4
P-3 Classifying: Utilizing simple groupings of objects or events based
on common properties 5.4
P-4 Measuring: Using appropriate metric units for measuring length,
volume, and mass
6.4
10.1
10.4
P-5
Predicting: Proposing possible results or outcomes of future
events based on observations and inferences drawn from previous
events
14.5
P-6 Inferring: Constructing an interpretation or explanation based on
information gathered
1.5
3.5
4.4
7.2
9.1
11.3
12.8
12.9
14.5
P-7
Controlling Variables: Recognizing the many factors that affect
the outcome of events and understanding their relationships to
each other whereby one factor (variable) can be manipulated while
others are controlled
6.4
10.1
10.4
14.5
P-8 Defining Operationally: Stating definitions of objects or events
based on observable characteristics
1.3
2.3
3.9
6.1
8.2
8.3
9.1
10.4
P-9 Formulating Hypotheses: Making predictions of future events
based on manipulation of variables
1.1
14.5
P-10
Experimenting (Controlled): Conducting scientific
investigations systematically, including identifying and framing
the question carefully, forming a hypothesis, managing variables
effectively, developing a logical experimental procedure,
recording and analyzing data, and presenting conclusions based
on investigation and previous research
1.5
3.5
4.4
7.2
9.1
11.3
12.8
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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COS Title Genetics Elective Core Bulletin 2005, No. 20
Std.
# COS Standard
HCS Unit-
Objective
12.9
14.5
P-11 Analyzing Data: Using collected data to accept or reject
hypotheses
1.5
3.5
4.4
7.2
9.1
11.3
12.8
12.9
14.5
EXPLORE / PLAN / ACT Standards for Transition Correlation: Science
Score
Range EPAS Standard
HCS Unit-
Objective
24 to 27
Compare data from a complex table, graph, or
diagram 1.3
Interpolate between data points in a table or graph 1.3
Identify or use a simple mathematical relationship
that exists between data 3.5
Identify a direct or inverse relationship between
variables in a complex table, graph, or diagram 1.3
Compare or combine data from two simple data sets 1.3
Combine new, simple information (data or text) with
given information (data or text) 1.3
Understand moderately complex lab procedures
1.5
3.5
4.4
7.2
9.1
11.3
12.8
12.9
14.5
Understand simple experimental designs
1.5
3.5
4.4
7.2
9.1
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
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Score
Range EPAS Standard
HCS Unit-
Objective
11.3
12.8
12.9
14.5
Select a simple hypothesis, prediction, or conclusion
that is supported by one or more data sets or
viewpoints
1.5
3.5
4.4
7.2
9.1
11.3
12.8
12.9
14.5
Identify strengths and weaknesses in one or more
viewpoints
11.1
11.2
11.3
11.4
11.5
11.6
11.7
11.8
11.9
Identify similarities and differences in two or more
viewpoints
11.1
11.2
11.3
11.4
11.5
11.6
11.7
11.8
11.9
Identify key issues or assumptions in an argument or
viewpoint
11.1
11.2
11.3
11.4
11.5
11.6
11.7
11.8
11.9
Determine whether new information supports or
weakens a viewpoint or hypothesis
11.1
11.2
11.3
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
Page 20 of 21
Score
Range EPAS Standard
HCS Unit-
Objective
11.4
11.5
11.6
11.7
11.8
11.9
28 - 32
Identify or use a complex mathematical relationship
that exists between data
13.1
13.2
13.3
13.4
3.4
3.5
Extrapolate from data points in a table or graph 1.3
Compare or combine given text with data from
tables, graphs, or diagrams 1.3
Understand complex lab procedures
1.5
3.5
4.4
7.2
9.1
11.3
12.8
12.9
14.5
Determine the hypothesis for an experiment 1.1
14.5
Understand moderately complex experimental
designs
1.5
3.5
4.4
7.2
9.1
11.3
12.8
12.9
14.5
Identify an alternate method for testing a hypothesis 1.1
14.5
Select a complex hypothesis, prediction, or
conclusion that is supported by a data set or
viewpoint
1.1
14.5
Select a set of data or a viewpoint that supports or
contradicts a hypothesis, prediction, or conclusion
11.1
11.2
11.3
HCS Curriculum: Science 6 – 12 Genetics and Biotechnology (High School)
Page 21 of 21
Score
Range EPAS Standard
HCS Unit-
Objective
11.4
11.5
11.6
11.7
11.8
11.9
Predict the most likely or least likely result based on
a given viewpoint
11.1
11.2
11.3
11.4
11.5
11.6
11.7
11.8
11.9
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