Carsten R. Smidt, Ph.D., FACNVice President, Global R&D, Pharmanex
What is LifePak?
A comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being.
LifePak Health Benefits
Optimum supplementation for general well-being
1. Addresses nutrient deficiencies2. Cardiovascular benefits3. Complete bone nutrition4. Promotes healthy immune function5. Supports blood sugar metabolism6. Protects against the symptoms of aging
7. Raises your antioxidant defense
1. Nutrient Deficiencies
Percent of Adults Not Meeting RDA
0
10
20
30
40
50
60
70
80
90
Males
Females
1. Nutrient Deficiencies
Percent of LifePak Users Not Meeting RDA
0
10
20
30
40
50
60
70
80
90
Males
Females
Over 40 Antioxidants: protect blood lipids (LDL) from oxidation by free radicals
2. Cardiovascular Benefits
(means +/- SD)
42.1 4243.4
50.9
30
35
40
45
50
55
60
65
Start After 6 Weeks
PlaceboLifePak
p < 0.001
Oxidized LDL clingsto artery lining,causing plaque build-up
Artery
Blood Pressure (Ca, Mg) Circulation (Flavonoids)
Inflammation (Flavonoids, Aox) Homocysteine (B-Vitamins)
US & EU: 23 million bone fractures per year due to osteoporosis = $27 billion medical costs
3. Bone Nutrients
3. Bone Nutrients• Calcium (500 mg): Major bone mineral; RDA: 1000-
1300 mg/day; typical intake: 800 mg/day• Magnesium (250 mg): Major bone mineral; RDA: 280-
320 mg/day• Vitamin D (400 IU): Regulates Ca & Mg bone
metabolism; deficiencies in Northern latitudes• Vitamin K (40 mcg): Ca transport into bone• Silicon (3 mg): Bone calcification & collagen• Boron (3 mg): Regulates bone cell function• Soy Isoflavones (5 mg): Reg. Ca metabolism
4. Immune FunctionLifePak promotes normal immune function• Vitamins A, C & E, Carotenoids, Vitamin B6 & Zinc
Percent of Adults Not Meeting RDA
0
10
20
30
40
50
60
70
80
90
Males
Females
LifePak promotes normal blood sugar, glucose tolerance and insulin metabolism• Chromium, 200 mcg:
– essential for normal insulin function– most diets are low in chromium (<50 mcg/day)
• Vitamin C, 500 mg• Vitamin E, 300 IU• Alpha-Lipoic Acid, 30 mg• Magnesium, 250 mg• Zinc, 15 mg
5. Blood Sugar & Insulin
LifePak Addresses the Root Cause of Aging:
DNA Damage• DNA (DeoxyriboNucleic Acid) is your genetic
blueprint • DNA enables healthy cell renewal into old age
6. Aging Symptoms
Body Cell
How Do We Age?
Weak Antioxidant Defense
DNA Damage
Free Radical Production
DNA Damage
Impaired Cellular Function and Cell Regeneration
Impaired Energy Production
Aging Symptoms
MitochondriaCell Nucleus
LifePak providesan arsenal of nutrients that
fight DNA damage,protect DNA, and
enhance DNA repair.
Green Tea and Longevity
66
68
70
72
74
76
78
80
82
Mea
n A
ge
of
Dea
th .
Men Women
3 or less
4 to 9
over 10
Green TeaConsumption(Cups/Day)
Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission
“… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.”
“It appears prudent for all adults to take vitamin supplements.”
Journal of the American Medical Association June 2002
Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard UniversityJournal of the American Medical Association 2002; 287: 3127-3129
7. Antioxidant Protection
Free Radicals Highly reactive, short-lived molecules Damage cells and genetic material (DNA)
70,000 free radical attacks on DNA every day in a cell Aging process Implicated in most health conditions Many different types of free radicals
Free Radicals & Antioxidants
Sources of Free Radicals
• Environmental pollution (smog, ozone, NO2) • Radiation exposure:
– sunlight (UV-light), X-rays, etc.• Smoking:
– 10,000,000,000,000,000 free radicals/cigarette!
• Metabolism in your mitochondria
Antioxidants fight free radicals Slow down aging process & improve health:
over 30,000 research studies on antioxidant health benefits affecting over 50 health conditions, incl.cardiovascular function, eye
health, CNS health, skin health, etc. Many antioxidants work together:
“Antioxidant Defense System” Relies on a steady supply of dietary antioxidants
Free Radicals & Antioxidants
LifePak 40+ Antioxidants
• All 8 forms of natural vitamin E: 300 IU• Buffered vitamin C: 500 mg• Selenium, Copper, Zinc, Manganese• 6 Carotenoids:
– as found in 5-10 fruits & vegetables per day • Over 20 Flavonoids:
– 6 Catechins, Quercetin, naringenin, hesperidin, 3 Soy isoflavones, Over 10 grape seed polyphenols
• Alpha-Lipoic Acid: 30-50 mg
LifePak Clinical StudyAntioxidant and Cardiovascular Health
42.1 42
43.4
50.9
30
35
40
45
50
55
60
65
Baseline Endpoint
PlaceboLifePak
p < 0.001
331299
335
716
0
200
400
600
800
1000
1200
Baseline Endpoint
PlaceboLifePak
p < 0.001
3.4773.429
6.248
3.305
0
1
2
3
4
5
6
7
8
Baseline Endpoint
PlaceboLifePak
p < 0.001
Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. FASEB Journal Vol.13 No.4, p.A546, March 1999. Full study report available upon request.
LDL Protection
Vitamin E
Beta-carotene
LifePak Antioxidant Capacity (ORAC)Jan 2003
0
500
1000
1500
2000
2500
3000
3500
Recommended daily antioxidant intake (R. Prior, USDA)
LifePak® - The Measurable Difference
• First to show antioxidant and cardiovascular benefits in double-blind studies
• 200,000+ published studies on LifePak’s antioxidants
• Nearly 800,000 published studies on all LifePak ingredients
• LifePak is built upon scientific consensus
Pharmanex BioPhotonic Scanner
• Measures Skin Carotenoids– Indicator of Antioxidant Status– Indicator of healthy diet/lifestyle
• Rapid & Non-Invasive• Scientifically Validated
Scanner Science is Measurable
• New York Academy of Sciences, Feb 2003• Oxygen Club of California, Feb 2003 and Feb 2004• FASEB/American Society of Nutritional Sciences - April 2003
and April 2004• Gordon Research Conference, Jan 2004• Review paper published in Current Topics in Nutraceutical
Research, May 2004 (available at
2004 Data Histogram Mean = 25,40632,948 Subjects
Skin Carotenoid Score
Fre
qu
en
cy
LifePak
5-9 Fruits & Vegetables
Average (2-3 Fruits & Vegetables)Smokers
Obesity
2004 Data: Fruits & Vegetables
31,100
28,560
24,773
21,981
10,000
15,000
20,000
25,000
30,000
35,000
1 or Less 2 to 3 4 to 5 6 or More
Reported Daily Fruit & Vegetable Servings
Ram
an
In
ten
sit
y, C
ou
nts
.
n = 9,336 n = 13,600 n = 6,916 n = 2,796
p < 0.01 p < 0.01 p < 0.01
2004 Data of 32,648 Non-Supplement Users
2004 Data: LifePak Usage
25,39026,236
34,718
29,672
10,000
15,000
20,000
25,000
30,000
35,000
40,000
None Irregular One/Day Two/Day
Reported LifePak Usage
Ram
an
In
ten
sit
y, C
ou
nts
.
n = 4,014n = 1,361n = 958n = 32,941
p < 0.01 p < 0.01 p < 0.01
2004 Data of 39,656 Subjects
Body Fat - Inverse Correlation
29,236
25,612
20,835
16,603
10,000
15,000
20,000
25,000
30,000
35,000
< 25 25-29 30-39 > 40
Body Mass Index (BMI, kg/m2)
Ram
an
In
tesit
y, C
ou
nts
.
n = 11,588 n = 8,475 n = 422
p < 0.01 p < 0.01 p < 0.01
n = 4,550
2004 Data of 25,035 Subjects Overweight individuals and anyone on a diet should increase antioxidant protection through diet and supplementation.
Clinical Study - Sep 2002 LifePak Scanner Score
32175
25991
28924
18828
10000
15000
20000
25000
30000
35000
40000
0 4 8 12Time (Weeks)
Ram
an
In
ten
sit
y, C
ou
nts
.
p < 0.001
p < 0.01
p = 0.23
Carotenoid Correlation Study June 2003
0
10,000
20,000
30,000
40,000
50,000
60,000
0.0 1.0 2.0 3.0 4.0
Total Serum Carotenoids (mg/ml)
Ra
ma
n In
ten
sit
y C
ou
nts
r = 0.78 p < 0.001
Smidt CR, Gellermann W, Zidichouski JA; FASEB Journal 18(4) pt.I:A480, 2004
A Global Look: Average Scan Scores
* Internal data on file
0
5000
10000
15000
20000
25000
30000
Ave. Score
Denmark
Hong Kong
Malaysia
Singapore
Thailand
Taiwan
U.S.
Japan
Skin Carotenoid Scores– Example of a person reading 25,000:
– REDRED: 19,000 and less: Poor diets, no/ineffective supplements, genetic factors, obesity, or smoking.
– YELLOWYELLOW: 20,000 - 29,000: Better diets and/or supplements.– GREENGREEN: 30,000 - 39,000: Healthy diets rich in fruits & vegetables
and/or good supplements.– BLUEBLUE: 40,000+: Excellent diets high in fruits & vegetables and
excellent supplements.
Media Coverage in 2003Self Magazine April 03
Elle Magazine Sep 03
Ms. Fitness Magazine Oct 03
NBC Today in LA
KNXV ABC News
Phoenix AZ News 3
WHDH-TV NBC Boston MA
WHAS 11 News Louisville KY
News All Morning New York
KUTV News Salt Lake City
NewsChannel 4 Columbus OH
CNBC Asia - Singapore
LifePak Health Benefits8. Helps maintain healthy eyes9. Promotes healthy teeth and gums10. Supports weight loss diets11. Promotes skin function & protection12. Prevents neural tube defects13. Supports energy metabolism14. Helps maintain mental performanceplus more...
Comprehensive & Convenient
>Multi
VitaminVitamin E
300 IU
Calcium &Magnesium
Chromium200 mcg
MultiCarotenes
Vitamin C500 mg
MultiFlavonoid
Better than these 7 popular supplements together.
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