Carsten R. Smidt, Ph.D., FACNVice President, Global R&D, Pharmanex

What is LifePak?

A comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being.

LifePak Health Benefits

Optimum supplementation for general well-being

1. Addresses nutrient deficiencies2. Cardiovascular benefits3. Complete bone nutrition4. Promotes healthy immune function5. Supports blood sugar metabolism6. Protects against the symptoms of aging

7. Raises your antioxidant defense

1. Nutrient Deficiencies

Percent of Adults Not Meeting RDA

0

10

20

30

40

50

60

70

80

90

Males

Females

1. Nutrient Deficiencies

Percent of LifePak Users Not Meeting RDA

0

10

20

30

40

50

60

70

80

90

Males

Females

Over 40 Antioxidants: protect blood lipids (LDL) from oxidation by free radicals

2. Cardiovascular Benefits

(means +/- SD)

42.1 4243.4

50.9

30

35

40

45

50

55

60

65

Start After 6 Weeks

PlaceboLifePak

p < 0.001

Oxidized LDL clingsto artery lining,causing plaque build-up

Artery

Blood Pressure (Ca, Mg) Circulation (Flavonoids)

Inflammation (Flavonoids, Aox) Homocysteine (B-Vitamins)

US & EU: 23 million bone fractures per year due to osteoporosis = $27 billion medical costs

3. Bone Nutrients

3. Bone Nutrients• Calcium (500 mg): Major bone mineral; RDA: 1000-

1300 mg/day; typical intake: 800 mg/day• Magnesium (250 mg): Major bone mineral; RDA: 280-

320 mg/day• Vitamin D (400 IU): Regulates Ca & Mg bone

metabolism; deficiencies in Northern latitudes• Vitamin K (40 mcg): Ca transport into bone• Silicon (3 mg): Bone calcification & collagen• Boron (3 mg): Regulates bone cell function• Soy Isoflavones (5 mg): Reg. Ca metabolism

4. Immune FunctionLifePak promotes normal immune function• Vitamins A, C & E, Carotenoids, Vitamin B6 & Zinc

Percent of Adults Not Meeting RDA

0

10

20

30

40

50

60

70

80

90

Males

Females

LifePak promotes normal blood sugar, glucose tolerance and insulin metabolism• Chromium, 200 mcg:

– essential for normal insulin function– most diets are low in chromium (<50 mcg/day)

• Vitamin C, 500 mg• Vitamin E, 300 IU• Alpha-Lipoic Acid, 30 mg• Magnesium, 250 mg• Zinc, 15 mg

5. Blood Sugar & Insulin

LifePak Addresses the Root Cause of Aging:

DNA Damage• DNA (DeoxyriboNucleic Acid) is your genetic

blueprint • DNA enables healthy cell renewal into old age

6. Aging Symptoms

Body Cell

How Do We Age?

Weak Antioxidant Defense

DNA Damage

Free Radical Production

DNA Damage

Impaired Cellular Function and Cell Regeneration

Impaired Energy Production

Aging Symptoms

MitochondriaCell Nucleus

LifePak providesan arsenal of nutrients that

fight DNA damage,protect DNA, and

enhance DNA repair.

Green Tea and Longevity

66

68

70

72

74

76

78

80

82

Mea

n A

ge

of

Dea

th .

Men Women

3 or less

4 to 9

over 10

Green TeaConsumption(Cups/Day)

Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission

“… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.”

“It appears prudent for all adults to take vitamin supplements.”

Journal of the American Medical Association June 2002

Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard UniversityJournal of the American Medical Association 2002; 287: 3127-3129

7. Antioxidant Protection

Free Radicals Highly reactive, short-lived molecules Damage cells and genetic material (DNA)

70,000 free radical attacks on DNA every day in a cell Aging process Implicated in most health conditions Many different types of free radicals

Free Radicals & Antioxidants

Sources of Free Radicals

• Environmental pollution (smog, ozone, NO2) • Radiation exposure:

– sunlight (UV-light), X-rays, etc.• Smoking:

– 10,000,000,000,000,000 free radicals/cigarette!

• Metabolism in your mitochondria

Antioxidants fight free radicals Slow down aging process & improve health:

over 30,000 research studies on antioxidant health benefits affecting over 50 health conditions, incl.cardiovascular function, eye

health, CNS health, skin health, etc. Many antioxidants work together:

“Antioxidant Defense System” Relies on a steady supply of dietary antioxidants

Free Radicals & Antioxidants

LifePak 40+ Antioxidants

• All 8 forms of natural vitamin E: 300 IU• Buffered vitamin C: 500 mg• Selenium, Copper, Zinc, Manganese• 6 Carotenoids:

– as found in 5-10 fruits & vegetables per day • Over 20 Flavonoids:

– 6 Catechins, Quercetin, naringenin, hesperidin, 3 Soy isoflavones, Over 10 grape seed polyphenols

• Alpha-Lipoic Acid: 30-50 mg

LifePak Clinical StudyAntioxidant and Cardiovascular Health

42.1 42

43.4

50.9

30

35

40

45

50

55

60

65

Baseline Endpoint

PlaceboLifePak

p < 0.001

331299

335

716

0

200

400

600

800

1000

1200

Baseline Endpoint

PlaceboLifePak

p < 0.001

3.4773.429

6.248

3.305

0

1

2

3

4

5

6

7

8

Baseline Endpoint

PlaceboLifePak

p < 0.001

Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. FASEB Journal Vol.13 No.4, p.A546, March 1999. Full study report available upon request.

LDL Protection

Vitamin E

Beta-carotene

LifePak Antioxidant Capacity (ORAC)Jan 2003

0

500

1000

1500

2000

2500

3000

3500

Recommended daily antioxidant intake (R. Prior, USDA)

LifePak® - The Measurable Difference

• First to show antioxidant and cardiovascular benefits in double-blind studies

• 200,000+ published studies on LifePak’s antioxidants

• Nearly 800,000 published studies on all LifePak ingredients

• LifePak is built upon scientific consensus

Pharmanex BioPhotonic Scanner

• Measures Skin Carotenoids– Indicator of Antioxidant Status– Indicator of healthy diet/lifestyle

• Rapid & Non-Invasive• Scientifically Validated

Scanner Science is Measurable

• New York Academy of Sciences, Feb 2003• Oxygen Club of California, Feb 2003 and Feb 2004• FASEB/American Society of Nutritional Sciences - April 2003

and April 2004• Gordon Research Conference, Jan 2004• Review paper published in Current Topics in Nutraceutical

Research, May 2004 (available at

2004 Data Histogram Mean = 25,40632,948 Subjects

Skin Carotenoid Score

Fre

qu

en

cy

LifePak

5-9 Fruits & Vegetables

Average (2-3 Fruits & Vegetables)Smokers

Obesity

2004 Data: Fruits & Vegetables

31,100

28,560

24,773

21,981

10,000

15,000

20,000

25,000

30,000

35,000

1 or Less 2 to 3 4 to 5 6 or More

Reported Daily Fruit & Vegetable Servings

Ram

an

In

ten

sit

y, C

ou

nts

.

n = 9,336 n = 13,600 n = 6,916 n = 2,796

p < 0.01 p < 0.01 p < 0.01

2004 Data of 32,648 Non-Supplement Users

2004 Data: LifePak Usage

25,39026,236

34,718

29,672

10,000

15,000

20,000

25,000

30,000

35,000

40,000

None Irregular One/Day Two/Day

Reported LifePak Usage

Ram

an

In

ten

sit

y, C

ou

nts

.

n = 4,014n = 1,361n = 958n = 32,941

p < 0.01 p < 0.01 p < 0.01

2004 Data of 39,656 Subjects

Body Fat - Inverse Correlation

29,236

25,612

20,835

16,603

10,000

15,000

20,000

25,000

30,000

35,000

< 25 25-29 30-39 > 40

Body Mass Index (BMI, kg/m2)

Ram

an

In

tesit

y, C

ou

nts

.

n = 11,588 n = 8,475 n = 422

p < 0.01 p < 0.01 p < 0.01

n = 4,550

2004 Data of 25,035 Subjects Overweight individuals and anyone on a diet should increase antioxidant protection through diet and supplementation.

Clinical Study - Sep 2002 LifePak Scanner Score

32175

25991

28924

18828

10000

15000

20000

25000

30000

35000

40000

0 4 8 12Time (Weeks)

Ram

an

In

ten

sit

y, C

ou

nts

.

p < 0.001

p < 0.01

p = 0.23

Carotenoid Correlation Study June 2003

0

10,000

20,000

30,000

40,000

50,000

60,000

0.0 1.0 2.0 3.0 4.0

Total Serum Carotenoids (mg/ml)

Ra

ma

n In

ten

sit

y C

ou

nts

r = 0.78 p < 0.001

Smidt CR, Gellermann W, Zidichouski JA; FASEB Journal 18(4) pt.I:A480, 2004

A Global Look: Average Scan Scores

* Internal data on file

0

5000

10000

15000

20000

25000

30000

Ave. Score

Denmark

Hong Kong

Malaysia

Singapore

Thailand

Taiwan

U.S.

Japan

Skin Carotenoid Scores– Example of a person reading 25,000:

– REDRED: 19,000 and less: Poor diets, no/ineffective supplements, genetic factors, obesity, or smoking.

– YELLOWYELLOW: 20,000 - 29,000: Better diets and/or supplements.– GREENGREEN: 30,000 - 39,000: Healthy diets rich in fruits & vegetables

and/or good supplements.– BLUEBLUE: 40,000+: Excellent diets high in fruits & vegetables and

excellent supplements.

Media Coverage in 2003Self Magazine April 03

Elle Magazine Sep 03

Ms. Fitness Magazine Oct 03

NBC Today in LA

KNXV ABC News

Phoenix AZ News 3

WHDH-TV NBC Boston MA

WHAS 11 News Louisville KY

News All Morning New York

KUTV News Salt Lake City

NewsChannel 4 Columbus OH

CNBC Asia - Singapore

LifePak Health Benefits8. Helps maintain healthy eyes9. Promotes healthy teeth and gums10. Supports weight loss diets11. Promotes skin function & protection12. Prevents neural tube defects13. Supports energy metabolism14. Helps maintain mental performanceplus more...

Comprehensive & Convenient

>Multi

VitaminVitamin E

300 IU

Calcium &Magnesium

Chromium200 mcg

MultiCarotenes

Vitamin C500 mg

MultiFlavonoid

Better than these 7 popular supplements together.