WuXi Biologics 2017 Interim Results · 6 First Half 2017 Overview: Revenue Revenue grew 59.5% YoY,...
Transcript of WuXi Biologics 2017 Interim Results · 6 First Half 2017 Overview: Revenue Revenue grew 59.5% YoY,...
WuXi Biologics2017 Interim Results
August 2017
(Stock Code: 2269.HK)
Forward-Looking Statements
This presentation may contain certain “forward-looking statements” are not historical facts, butinstead are predictions about future events based on our beliefs as well as assumptions made by andinformation currently available to our management. Although we believe that our predictions arereasonable, future events are inherently uncertain and our forward-looking statements may turn outto be incorrect. Our forward-looking statements are subject to risks relating to, among other things,the ability of our service offerings to compete effectively, our ability to meet timelines for theexpansion of our service offerings, and our ability to protect our clients’ intellectual property. Ourforward-looking statements in this presentation speak only as of the date on which they are made,and we assume no obligation to update any forward-looking statements except as required byapplicable law or listing rules. Accordingly, you are strongly cautioned that reliance on any forward-looking statements involves known and unknown risks and uncertainties. All forward-lookingstatements contained herein are qualified by reference to the cautionary statements set forth in thissection.
2
Use of Adjusted Financial Measures
3
We have provided adjusted net profit, net profit margin, EBITDA, EBITDA margin and dilutedearnings per share for the first half of 2016 and 2017, which excludes share-based compensationexpenses, listing expenses and foreign exchange loss, and are not required by, or presented inaccordance with, IFRS. We believe that the adjusted financial measures used in this presentation areuseful for understanding and assessing underlying business performance and operating trends, andwe believe that management and investors may benefit from referring to these adjusted financialmeasures in assessing our financial performance by eliminating the impact of certain unusual andnon-recurring items that we do not consider indicative of the performance of our business. However,the presentation of these non-IFRS financial measures is not intended to be considered in isolationor as a substitute for the financial information prepared and presented in accordance with IFRS. Youshould not view adjusted results on a stand-alone basis or as a substitute for results under IFRS, oras being comparable to results reported or forecasted by other companies.
Agenda
I. Results Highlights
II. Business Operational Overview
III. Financial Overview
IV. Growth Strategies and Conclusion
V. Appendix
VI. Q&A session
4
`
I. Results Highlights
6
First Half 2017 Overview: Revenue
Revenue grew 59.5% YoY, from RMB410.1 million to RMB654.0 million
Revenue growth in the United States, China, Europe, and Rest of World
were 53%, 58%, 1,664%, and 58% YoY, respectively
Phenomenal backlog growth to US$452 million as of June 30, 2017, vs
US$68 million as of June 30, 2016 and US$383 million as of May 23, 2017
Increasingly solid track record in the global competition
Successful execution of business development in Europe
Doubling of our late phase (phase III) projects from 3 to 6 requiring
more large-scale manufacturing
We expect strong revenue growth to continue in 2H 2017
7
First Half 2017 Overview: Profitability
Despite of the ramp-up of a new facility, our 1H 2017 gross margin of 40.4%
was still higher than that of full year of 2016, 39.3%.
Adjusted EBITDA grew 51.7% YoY, from RMB175.4 million to RMB266.1
million. Adjusted EBITDA margin of 1H 2017 was 40.7% vs 37.5% for 2016
Gross profit margin of 40.4%, adjusted EBITDA margin of 40.7% and
adjusted net profit margin of 23.4% all beat full year 2016 numbers
8
First Half 2017 Overview: Cash
Net operating cashflows improved to RMB227.3 million from negative
RMB60.0 million in 1H 2016
We raised a net proceeds of equivalent approximately RMB3,367.9 million
from IPO
Cash and cash equivalents amounted to RMB3,619.8 million as of June 30,
2017
We repaid around RMB1 billion bank loan as of July 31, 2017 and expect to
repay bridge loan of US$38.6 million in early September 2017
Interest expense will be significantly reduced in 2H 2017
9
First Half 2017 Operational Highlights
Record high number of integrated projects, increased from 75 as of June 30,
2016, 103 as of January 2017, to 134 as of June 30, 2017
Number of late phase (phase III) projects doubled to 6 as of June 30, 2017 from
3 at the time of our IPO, requiring more process development and large-scale
GMP manufacturing: significant contributions to backlog growth
Expansion plan of our two new facilities on schedule
30,000L commercial manufacturing capacity at Wuxi city: 2x1,000L
perfusion line operational, 1st batch completed Q2 2017; 14x2,000L fed-
batch line in validation, expect operational Q4 2017
7,000L clinical manufacturing capacity in shanghai: shell construction and
equipment order in progress, expect operational Q2 2018. Once completed,
will more than double the clinical manufacturing capacity
10
Recent Operational Highlights
Rapid expansion of talent base from 1,624 employees as of December 31, 2016
to 1,998 employees as of June 30, 2017, which enables sustainable revenue
growth. Expect Headcount to reach 2,600-2,800 by December 2017
Out-licensing of the Fully Human PD-1 Antibody (GLS-010) to Arcus Biosciences
Our China gateway and global capabilities allow us to increase our
potential revenues significantly for each molecule
US$18.5 million upfront payment expected 2nd half of 2017
Total US$816 million milestone payments and up to 10% royalty
Exclusive manufacturer for GLS-010
Three-year exclusive partner for developing Arcus’ biologics portfolio
First PLI Audit in China– Validation of Our “Follow-the-Molecule” Strategy
11
On August 3, 2017, the U.S. FDA completed the PLI for production of ibalizumab with no critical observations
The five-inspector, 13-day inspection covered both drug substance and drug product facilities in the city of Wuxi, China
We expect to complete all follow-up actions by October 2017
First commercial batch is expected to be delivered in 1Q 2018, if approved
First commercial manufacturing project for WuXi Biologics
This validated both our global quality standard and pioneer use of disposable bioreactors for commercial manufacturing
First Biologics
PLI in China
Inspected facilities will be the first cGMP biologics manufacturing facilities in China approved by the
U.S. FDA for a commercial biologics product
If ibalizumab is approved
`
II. Business Operational Review
Our Mission and Business Model
To transform and accelerate pharmaceutical discovery, development and manufacturing in the fast growing field of biologics to benefit patients worldwide
Our Mission
Our Strong Proprietary Technology Platform
Our customers’ demand for our services increases as their biologics advance through development and ultimately to commercialization, which allows our revenue from each project to grow geometrically as the project advances through the biologics
development cycle
Our “Follow the Molecule” Integrated Solution Model
Biologics Characterization &
Testing Platform
Proprietary Cell Line Development
Platform
Biologics Discovery Platform
State-of-the-art Cell Culture Platform
Biologics & ADC Manufacturing
Platform
Biologics Formulation Platform
13
Solid Business Progress
68
280
383
452
0
50
100
150
200
250
300
350
400
450
500
Jun 2016 Jan 2017 May 2017* Jun 2017
Backlog
USD mm
Analysis of Integrated Projects (1) By Phases
59
14
2
66
33
3 1
90
33
3 1
92
35
61
0
10
20
30
40
50
60
70
80
90
100
PreclinicalDevelopment
Early Phase Late Phase CommercialManufacturing
Jun 2016
Jan 2017
May 2017
Jun 2017
Drug Discovery Preclinical Development Early Phase (Phase I & II) Late Phase (Phase III) Commercial Manufacturing
PRE-IND POST-IND
US$1.5-2.5 mm US$4-6 mm US$4-6 mm US$20-50 mm US$50-100 mm(2)Typical Revenue
For Stage:
92 35 6 1
Total: 134On-Going Integrated
Project Numbers(1):
Notes: 1. Integrated projects are projects that require us to provide services across different stages of the biologics development process2. Estimated value when a biologic drug reaches peak sales. A biologic drug typically reaches peak sales after a ramp-up period
*May 2017 is the Latest Practicable Date for IPO prospectus
No. of Integrated Projects (1)
75
103
127134
0
20
40
60
80
100
120
140
160
Jun 2016 Jan 2017 May 2017* Jun 2017
14
`
III. Financial Overview
Phenomenal Financial Performance
Adjusted Net Profit (2)
331.9
557.0
989.0
410.1
654.0
0
300
600
900
1,200
2014 2015 2016 1H2016 1H2017
Revenue
RMB mm
98.7145.3
370.8
175.4
266.1
0
150
300
450
600
2014 2015 2016 1H2016 1H2017
Adjusted EBITDA (1)
RMB mm 29.7% 26.1% 42.8% 40.7%37.5%
42.0 44.5
141.183.9 92.24.8 26.9
47.6
22.830.7
0.1
13.8
31.9
8.5
16.1
46.864.9
219.1
112.5152.8
0
70
140
210
280
2014 2015 2016 1H2016 1H2017
RMB mm
12.6%
14.1%
8.0%
11.7%
14.3%
22.2%
20.5%
27.4%
14.1%
23.4%
Notes: 1. Adjusted EBITDA represents net profit before (i) interest income and expense, income tax expenses and (ii) certain non-cash expenses, consisting of share-based compensation, amortization, depreciation and impairment of
goodwill and (iii) FX gains and losses2. Adjusted net profit excludes share-based compensation, foreign exchange gain or losses, and listing expense; For the year of 2015, 2016 and period of 1H 2016, the company recorded foreign exchange gains
16
RMB mm
Listing ExpenseAdjusted Margin % SBC ImpactUnadjusted Margin % FX Impact
Gross Profit
123.3180.7
389.1
186.6
264.3
0
150
300
450
600
2014 2015 2016 1H2016 1H2017
37.1% 32.4% 39.3% 45.5% 40.4%
Robust Growth Across All Geographic Markets (1)
Rest of the world (3)
Notes: 1. Geographic breakdown by client headquarters2. Decline in revenue from PRC in 2015 due to a substantial number of on-going project-based service contracts and work orders with Chinese customers pending standard regulatory approvals in 20153. Rest of the world primarily includes Canada, Israel, Japan, India and South Korea
RMB mm
1H2016 Revenue
United States of America
52.3%
PRC39.1%
Europe 3.0%
Rest of the World5.6%
1H2017 Revenue
RMB654.0 mm
PRCRMB mm
United States of America
107.6
354.6
505.0
223.9
342.3
2014 2015 2016 1H2016 1H2017
RMB mm
Europe RMB mm
(2)
191.3 158.8
385.3
161.9
255.6
2014 2015 2016 1H2016 1H2017
2.6 5.1
21.1
1.1
19.4
2014 2015 2016 1H2016 1H2017
30.4 38.5
77.6
23.2
36.7
2014 2015 2016 1H2016 1H2017
United States of America
54.6%
PRC39.5%
Europe 0.3%
Rest of the World5.6%
RMB410.1 mm
17
Revenue Breakdown by Development Process Stages
Revenue by Development Process Stages
RMB mm
18
277.5334.7
681.3
298.2
448.3
54.4
222.3
307.7
111.9
205.7
331.9
557.0
989.0
410.1
654.0
0
250
500
750
1,000
2014 2015 2016 1H2016 1H2017
Pre-IND Services Post-IND Services
83.6%
16.4%
60.1%
39.9%
27.3%
72.7%
31.5%
68.5%
68.9%
31.1%
Capital Expenditure and Use of Proceeds
51.0
334.4428.9
~1,008
0
400
800
1,200
2014 2015 2016 2017E
RMB mm
Purchase of Plants and Equipment Use of Proceeds
19
As of July 31, 2017, the Group has subsequently repaid the syndicated loanborrowed from SPDB & Pingan in full (approximately RMB 1 billion).
% of Total Net Proceeds
Use of Proceeds
36%To repay all the Group’s outstandingbank facilities
56%To construct new facilities, as well asimprove and maintain existing facilities
8%For the Group’s working capital andother general corporate purposes
1H 2017 Financial Summary
(RMB million) 1H 2017 1H 2016 Change
Revenue 654.0 410.1 59.5%
Cost of services (389.8) (223.5)
Gross Profit 264.3 186.6 41.6%
Other income 16.1 5.1
Other gains and losses (15.9) (0.8)
Selling and marketing expenses (13.3) (6.6)
Administrative expenses (51.1) (39.8)
Research and development expenses (36.4) (30.1)
Other expenses (16.1) (8.5)
Financial Cost (31.3) (8.1)
Profit before Tax 116.2 97.8 18.8%
Income Tax Expenses (24.0) (13.9)
Profit and total comprehensive income for the period 92.2 83.9 9.9%
Earnings per share – Basic (RMB) 0.09 0.09
Earnings per share – Diluted (RMB) 0.09 0.09
20*Result may not foot due to rounding
Reconciliation for Adjusted net profit and Adjusted EBITDA
21
(RMB million) 1H 2017 1H 2016
Adjusted net profit Reconciliation
Net profit 92.2 83.9
Share-based Compensation 30.7 22.8
Listing Expenses 16.1 8.5
Foreign Exchange (Gain) or Loss 13.8 (2.7)
Adjusted net profit 152.8 112.5
Adjusted EBITDA Reconciliation
EBITDA 205.5 146.8
Share-based Compensation 30.7 22.8
Listing Expenses 16.1 8.5
Foreign Exchange (Gain) or Loss 13.8 (2.7)
Adjusted EBITDA 266.1 175.4
`
IV. Growth Strategies and Conclusion
Growth Strategies
23
• Expand Commercial and Research Manufacturing Capacities
• Invest in Cutting-edge Technologies through Both In-house Research and Development and Potential Acquisitions
• Building upon Strong Customer Relationships to Secure New Projects from Existing Customers
• Leveraging the Existing Market Position to Expand the Customer Base
• Continue to Attract, Train and Retain Quality Talent to Support Our Rapid Growth
• Capitalize on Our Strategic China Location to Provide Customers with a Unique Value Proposition
1 2
3 4
5 6
We delivered another strong performance for the first half of 2017, and weexpect this strong growth to continue in 2H 2017
FDA PLI completion is a key milestone for our commercial manufacturingcapabilities
Our capacity expansion is on schedule which enables us to continue to deliversustainable growth
Recent out-licensing of GLS-010 to Arcus Biosciences shows that our Chinagateway and global capabilities allow us to increase potential revenuessignificantly for each molecule. Expect significant milestone payments androyalties if the product is approved
Conclusion
24
`
V. Appendix
Share Count Information
Date Description No. of Shares
27-Feb-2017 Share Issued 964,000,000
13-Jun-2017 Shares of Global Offering 170,118,057
14-Jun-2017 Exercise of Over-allotment 28,947,000
Sub-total Share Issued and Outstanding 1,163,065,057
First Half of 2017 Share Options Exercised -
30-Jun-2017 Weighted Average Number of Ordinary Shares-Basic 983,636,597
30-Jun-2017 Share Options and Equivalents 45,919,209
30-Jun-2017 Weighted Average Number of Ordinary Shares-Diluted 1,029,555,806
26
`
Q&A Session
THANK YOU!