What is Transdermal Pain Therapy? Study Involving TC …meddevicedepot.com/PDFs/TPBrochure.pdf ·...
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Fx: RESULTS The data indicate that PCCA’s Lipoderm® delivered ketamine HCl, gabapentin, clonidine HCl and baclofen, simultaneously (and intact), into and through human cadaver skin, in vitro. The absorption profiles indicate a rapid penetration to a peak flux for gabapentin and baclofen occurring approximately one (1) hour after dose application, and approximately four (4) hours for ketamine HCl. Clonidine HCl exhibited a rapid penetration to an initial peak flux occurring one (1) hour after dose application, but also a secondary peak at approximately 40 hours, possibly due to a depot of some of the applied dose in the epidermis. (See Figures 1 through 5.) This one-of-a-kind study validates the ability of Lipoderm® to deliver four drugs simultaneously through human skin. This information is of great value for pharmacists and physicians utilizing topical preparations for various pain syndromes. What can Transdermal Pain Therapy be used for? Achilles Tendonapathy Acute Pain Burning Foot Syndrome Bursitis Chemotherapy Induced Peripheral Neuropathy (CIPN) Complex Regional Pain Syndrome (CRPS) Diabetic Peripheral Neuropathy (DPN) Epicondylitis Failed Back Syndrome Fibromyalgia Frozen Shoulder Gout Lateral & Medial Epicondylitis Low Back Pain Medial-tibial Stress Syndrome Myofascial Pain Syndrome Osteoarthritis Peripheral Neuropathy Phantom Limb Pain Plantar Fasciitis Post Herpetic Neuralgia (PHN) Post-op Pain Radiculopathy Rheumatoid Arthritis Sciatica Shingles Sports Injuries Tendonitis Tendonosis Temporomandibular Joint Disorder (TMJ) Trigemial Neuralgia Lipoderm ® Proven to Deliver Four Drugs Simultaneously Through Human Skin In Vitro – FIRST STUDY OF ITS KIND! What is Transdermal Pain Therapy? Study Involving TC Neuromax’s Transdermal Cream (Lipoderm ® ) A Possible Solution for You and Your Patients: Transdermal pain therapy targets neuropathic, musculoskeletal and inflammatory pain by combining drugs with multiple mechanisms of action into an innovative delivery system. • Provides localized enhanced drug delivery directly to the site of pain • Drugs for pain are incorporated into a proprietary transdermal cream that has proven results to deliver multiple drugs through the skin (see study on following page) • Unique options for patients and confidence for prescribers Nearly two in five (36%) Americans would refuse prescribed or physician- recommended pain medication for fear of getting addicted. One in three (34%) Americans believe pain medications that come with side effects are worse than the pain itself. One in three (31%) Americans would not even speak to a medical professional about their pain for fear they could not afford treatment. Concentration of therapeutic levels of many drugs is higher in tissues while lower in serum Comparison and evaluation of topical NSAIDs are difficult due to the diversity of presentations of the marketed drugs and variety of methods used in the trials. Overall, when NSAIDs are applied topically, a high concentration is observed in the dermis and muscles (equivalent to that obtained with oral route), with less gastrointestinal effects. Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048583/ American Osteopathic Association Survey , October 2010 Common Challenges with Oral Medications: 1. Lack of Efficacy 2. Patient develops tolerance 3. GI side effects 4. Nausea 5. Constipation 6. Gastric bleeding 7. CNS side effects 8. Confusion 9. Change in mood/misuse 10. Abuse/Overdose * * More than 16,500 people die of overdoses from prescription painkillers annually, more than all illegal drugs combined (including Heroin and Cocaine) Source : Centers for Disease Control & Prevention Benefits of Transdermal Pain Therapy: 1. Ease of administration/application for patients; do not need to swallow multiple medications 2. Ability to combine multiple drugs into one dose 3. Provides a goal for pain relief with reducing the dose or need for oral narcotics 4. Option for prescriptions with non-controlled drugs 5. Less potential systemic drug absorption with the goal of fewer side effects
Transcript of What is Transdermal Pain Therapy? Study Involving TC …meddevicedepot.com/PDFs/TPBrochure.pdf ·...
Fx:
RESULTS The data indicate that PCCA’s Lipoderm® delivered ketamine HCl, gabapentin, clonidine HCl and baclofen, simultaneously (and intact), into and through human cadaver skin, in vitro. The absorption profiles indicate a rapid penetration to a peak flux for gabapentin and baclofen occurring approximately one (1) hour after dose application, and approximately four (4) hours for ketamine HCl. Clonidine HCl exhibited a rapid penetration to an initial peak flux occurring one (1) hour after dose application, but also a secondary peak at approximately 40 hours, possibly due to a depot of some of the applied dose in the epidermis. (See Figures 1 through 5.) This one-of-a-kind study validates the ability of Lipoderm® to deliver four drugs simultaneously through human skin. This information is of great value for pharmacists and physicians utilizing topical preparations for various pain syndromes.
What can Transdermal Pain Therapy be used for?
Achilles TendonapathyAcute PainBurning Foot Syndrome BursitisChemotherapy Induced Peripheral Neuropathy (CIPN)Complex Regional Pain Syndrome (CRPS)Diabetic Peripheral Neuropathy (DPN)EpicondylitisFailed Back SyndromeFibromyalgiaFrozen ShoulderGoutLateral & Medial EpicondylitisLow Back PainMedial-tibial Stress SyndromeMyofascial Pain Syndrome
OsteoarthritisPeripheral NeuropathyPhantom Limb PainPlantar FasciitisPost Herpetic Neuralgia (PHN)Post-op PainRadiculopathyRheumatoid ArthritisSciaticaShinglesSports InjuriesTendonitisTendonosisTemporomandibular Joint Disorder (TMJ)Trigemial Neuralgia
Lipoderm® Proven to Deliver Four Drugs SimultaneouslyThrough Human Skin In Vitro – FIRST STUDY OF ITS KIND!
What is Transdermal Pain Therapy? Study Involving TC Neuromax’s Transdermal Cream (Lipoderm®)
A Possible Solution for You and Your Patients:Transdermal pain therapy targets neuropathic, musculoskeletal and inflammatory pain by combining drugs with multiple mechanisms of action into an innovative delivery system.• Provides localized enhanced drug delivery directly to the site of pain• Drugs for pain are incorporated into a proprietary transdermal cream that has proven
results to deliver multiple drugs through the skin (see study on following page)• Unique options for patients and confidence for prescribers
Ph: 888.290.2244 Fx: 866.587.8915www.tcneuromax.com Ph: 888.290.2244 Fx: 866.587.8915www.tcneuromax.com
Nearly two in five (36%) Americans would refuse prescribed or physician-recommended pain medication for fear of getting addicted.
One in three (34%) Americans believe pain medications that come with side effects are worse than the pain itself.
One in three (31%) Americans would not even speak to a medical professional about their pain for fear they could not afford treatment.
Concentration of therapeutic levels of many drugs is higher in tissues while lower in serumComparison and evaluation of topical NSAIDs are difficult due to the diversity of presentations of the marketed drugs and variety of methods used in the trials. Overall, when NSAIDs are applied topically, a high concentration is observed in the dermis and muscles (equivalent to that obtained with oral route), with less gastrointestinal effects. Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048583/
American Osteopathic Association Survey , October 2010
Common Challenges with Oral Medications:1. Lack of Efficacy2. Patient develops tolerance3. GI side effects4. Nausea5. Constipation
6. Gastric bleeding7. CNS side effects8. Confusion9. Change in mood/misuse10. Abuse/Overdose *
* More than 16,500 people die of overdoses from prescription painkillers annually, more than all illegal drugs combined (including Heroin and Cocaine) Source : Centers for Disease Control & Prevention
Benefits of Transdermal Pain Therapy:1. Ease of administration/application for patients; do not need to swallow multiple medications2. Ability to combine multiple drugs into one dose3. Provides a goal for pain relief with reducing the dose or need for oral narcotics4. Option for prescriptions with non-controlled drugs5. Less potential systemic drug absorption with the goal of fewer side effects
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MEDICATION DEFINITION | USES
Amitriptyline Neuropathic pain
Baclofen Muscle relaxer, anti-spasmatic
Bromelain Proteolytic enzyme
Bupivacaine Local anesthetic
Clonidine Neuropathic pain
Colchicine Gout
Cyclobenzaprine Muscle relaxant
Flurbiprofen NSAID; inflammatory pain
Gabapentin Neuropathic pain
Ketamine Neuropathic pain
Nifedipine It is often used transdermally to increase circulation
Pentoxifylline Part of TC Neuromax transdermal base. Proposed mechanism in the pain cascade on IL-6 and tumor necrosis factor (TNF)
Tranilast Part of TC Neuromax transdermal base. Proposed mechanism in the pain cascade on IL-6 and TNF
www.tcneuromax.com
Transdermal Pain Therapy
106 Prospect Street Ridgewood, NJ 07450Ph: 888.290.2244 Fx: 866.587.8915
Leading the way withCompassionate Care Expertise
in Transdermal Pain Therapy
TC Neuromax Transdermal Pain Creams
For specific medication questions please email [email protected]
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