WELCOME [] · Personalized Medicine - enabling hypothesis driven patient stratification and...
Transcript of WELCOME [] · Personalized Medicine - enabling hypothesis driven patient stratification and...
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WELCOME
Otmar D. Wiestler, M.D. President of the Helmholtz Association
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• Systems solutions for grand challenges based on: • Scientific excellence
• Interdisciplinarity and critical mass
• long term research programs
• Helmholtz provides a highly attractive environment for talents and brilliant brains
• Profound expertise in large scale research infrastructure
• Transfer of knowledge into economy and society
HELMHOLTZ RESEARCH MISSION & STRATEGY
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HELMHOLTZ CENTERS
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FACTS AND FIGURES
Staff
Budget 2016
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EARTH AND ENVIRONMENT
RESEARCH PORTFOLIO of the Helmholtz Association
ENERGY HEALTH
AERONAUTICS, SPACE AND TRANSPORT
MATTER
KEY TECHNOLOGIES
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HELMHOLTZ FUTURE CHALLENGES
• Energy research (storage, future energy systems)
• Exploring the system earth
• Future mobility concepts
• Personalized medicine (eHealth, PoC, prevention)
• Helmholtz Incubator Information & Data Science
SEITE 6
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Five Disease-related Programs
Cardiovascular and Metabolic Diseases
Infection Research
Cancer Research
DKFZ, MDC, HZDR, GSI MDC, DKFZ
HZI
Diseases of the Nervous System
DZNE, MDC
Genes and Environment in Common Diseases
HMGU, UFZ
Largescale Research Infrastructure
National
Cohort
DKFZ, HMGU, MDC, HZI
HEALTH RESEARCH CENTERS AND PROGRAMS
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HELMHOLTZ RESEARCH FIELD HEALTH
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• Basic research: disease mechanisms
• Unravel complex systems
• Translational research
• Focus on major diseases
• Strategic alliances
Grand challenges :
• Preventive medicine
• Personalized medicine
• E – Health
• Psychiatric disease
Helmholtz Cohort / MDC
Drug research, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) / HZI
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TRANSLATION CENTERS - Helmholtz & University Medicine
• Close interaction between Helmholtz Research Centers and clinical partners under one roof
• Preclinical research and development
• Early clinical evaluation of innovative tools for diagnosis, therapy and prevention
• Platform for novel PPP alliances Helmholtz Center
Branch of a Helmholtz Center
Helmholtz Head Office
List
Helgoland
Bremerhaven Geesthacht Hamburg
Greifswald
Braunschweig
Wolfenbüttel-Remlingen
Göttingen
Magdeburg
Potsdam
Berlin
Zeuthen
Teltow
Niemegk
Halle
Leipzig Bad
Lauchstädt
Köln
Jülich
Bonn
Darmstadt
Heidelberg
Lampoldshausen
Karlsruhe
Stuttgart
München
Garching Neuherberg
Oberpfaffenhofen
ECRC Berlin
TWINCORE Hannover
CPC Munich
NCT Heidelberg
DZNE Bonn
MARC, Diabetes Study Center Munich
Slide 9
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Helmholtz-Centre Pulmonary diseases
Neurodegenerative diseases
Diabetes
Cadio-vascular diseases
Cancer (DKTK)
Infections
GERMAN CENTRES FOR HEALTH RESEARCH
• Focus on translational research and personalized medicine
• Equal and long-term partnership between research institutions, universities, university clinics and clinics
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THE NATIONAL COHORT
• Large prospective cohort
• Unique platform: 200,000 adults (20-69 years), follow- up for up to 30 years
• 18 Centers in representative regions
• Close cooperation between Helmholtz Centers (DKFZ, HMGU, MDC, HZI), Universities and Leibniz Institutes
• Start of recruitment October 2014
• Central biorepository for about 20 million samples at HMGU
Slide 11 Biorepository
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PERSONALIZED MEDICINE
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Personalized Medicine - enabling hypothesis driven patient stratification and
individualized diagnostics, therapies and prevention.
• Joint initiative of Helmholtz Research Field Health in close cooperation with academic medicine
• Common platform for high-throughput and information technologies
• Know-how and Life Science Technologies for molecular characterization of individual patients and application in the clinical setting
• Novel tailored therapies with maximum efficacy and minimum adverse effects
• Potential for personalized early detection and prevention (link to National Cohort)
CROSS-PROGRAM INITIATIVE
Slide 13
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HELMHOLTZ INSTITUTE FOR
TRANSLATIONAL ONCOLOGY (HI-TRON)
• German Cancer Research Center, TRON, Mainz University Faculty of Medicine, Johannes Gutenberg University Mainz
• Development of personalized oncology based on cancer immunotherapy at the international forefront
• “The proposed HI-TRON is uniquely positioned to become a world leader in accelerating scientific, technical and clinical advances in this space.”
• “The overall concept and strategy is of outstanding scientific quality in the identification of biomarkers and the development of efficient new cancer therapies.”
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DIGITAL HEALTH & DATA SCIENCE
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• Incubator on „Information and Data Science “
• Strategic process for linking IT activities within the Helmholtz Association
• Contribution of all centers and research fields
• Program for data scientists
• Links between IT and Medicine
• Program „Decoding the human brain“
• Technologies and research on soft matter and biointerfaces
• Data There House for biomedical resaerch
• Cloud architectures (genome cloud)
INFORMATION AND DATA SCIENCE
Forschungszentrum Jülich
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INFORMATION PROCESSING & BIG DATA IN BIOMEDICAL RESEARCH
• Data warehouse structures
• Clinical & research data
• Big data analytics
• Mesh computing
• Simulation, modelling
• Machine learning
• Data exchange
• Data protection
• Alliances between biomedical resaerch, academic medicine and IT industries
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Display Data from Various Sources for a Comprehensive Overview of Information Relevant for Personalized Treatment
NCT GOES SAP HANA – NCT DATA THERE HOUSE
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FUTURE DEVELOPMENTS IN BIOMEDICAL RESEARCH
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POSSIBLE CORE ELEMENTS FOR ADVANCING HEALTH RESEARCH IN GERMANY
• Establishment of a Proof-of-Concept-platform
• Development and implementation of unified / interoperable HealthCare IT-concepts
• Joint initiatives for multi-site infrastructures in biomedical research
• Training programs for physician scientists
• Local centers of excellence for defined diseases entities
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THANK YOU
Otmar D. Wiestler, M.D. President of the Helmholtz Association