Dr Mehran Gholamin

Associate Professor of Immunology

       

Updated at: July 2019

Address: Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad,, IranTel: +985138846710-20,112Fax: +985138846728

gholaminm@mums.ac.ir

und Educational Background 2003–2009 Ph.D., Immunology, Mashhad University of Medical Sciences (MUMS), Iran. Advisor: 1998-2000 M.Sc. Immunology, Mashhad University of Medical Sciences1995-1997 Bachelor in Medical Technology, Iran University of Medical Sciences1986-1989 Lab Technician, Iran University of Medical Sciences

Research InterestsCancer ImmunologyCancer ImmunotherapyCancer Stem CellsBrain tumor markerIsolation Beta cells

Publications

1. Analysis of Interleukin 4 and 13 Gene Polymorphisms in Allergic Rhinitis: A Case Control Study2. Green synthesis of 99 mTc -labeled- Fe3O4 nanoparticles using Quince seeds extract and

evaluation of their cytotoxicity and biodistribution in rats3. Correlation between expression of CatSper1,2 and sperm parameters in the gamma irradiated adult mouse testis4. Role of MAML1 in targeted therapy against the esophageal cancer stem cells5. Isolation and identification of chemotherapy-enriched sphere-forming cells from a patient with gastric cancer.6. Induction of T cell-mediated immune response by dendritic cells pulsed with mRNA of sphere-forming cells

isolated from patients with gastric cancer7. Ectopic Expression of Human DPPA2 Gene in ESCC Cell Line Using Retroviral System8. Effect of cadmium and nickel on expression of CatSper 1 and 2 genes in mice9. Association of Two CD44 Polymorphisms with Clinical Outcomes of Gastric Cancer Patients10. Cytokine networks and their association with Helicobacter pylori infection in gastric carcinoma11. Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury12. TWIST1 upregulates the MAGEA4 oncogene13. Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter

Pylori infection14. Role of Oxidative Stress in Modulating Unfolded Protein Response Activity in Chronic Myeloid Leukemia Cell

Line15. Bagheri V, Razavi MS, Momtazi AA, Sahebkar A, Abbaszadegan MR, Gholamin M. Isolation, Identification,

and Characterization of Cancer Stem Cells: A Review, J Cell Physiol. 2016 Dec 26. doi: 10.1002/jcp.25759. Epub 2017 Feb 28.

16. Bagheri V, Memar B, Momtazi AA, Sahebkar A, Abbaszadegan MR, Gholamin M., Cytokine Networks and Their Association with Helicobacter pylori Infection in Gastric Carcinoma, J Cell Physiol. 2017 Jan 25. doi: 10.1002/jcp.25822. [Epub ahead of print] Review.

17. Sheibani S, Mahmoudian RA, Abbaszadegan MR, Chamani J, Memar B, Gholamin M, Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter Pylori infection. Cancer Biomark. 2017 Jan 20. doi: 10.3233/CBM-160127. [Epub ahead of print]

18. Moghbeli M, Rad A, Farshchian M, Taghehchian N, Gholamin M, Abbaszadegan MR, Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma. J Gastrointest Cancer; 2016 May 4

19. Maryam Khaleghizadeh, Mohammad Reza Abbaszadegan, Mehran Gholamin, Mohammad Mahdi Forghanifard, Isolation and Cloning of Human Developmental Pluripotency Aassociated-2 Cancer Testis Gene, Genetics in the Third Millennium; 3760-3754(4)12,2015

20. Maryam Sedighi, Seyed Amir Aledavood, MR Abbaszadegan, Bahram Memar, Mehdi Montazer, Majid Rajabian , Mehran Gholamin, Matrix metalloproteinase - 13(MMP13); Potential biomarker for early detection and survival of patients with esophageal squamous cell carcinoma, Asian Pacific Journal of Cancer Prevention;2016 (In press)

21. Reihaneh alsadat Mahmoudian, Mohammad Reza Abbaszadegan, Atena Mansouri, Mehran Gholamin, Amplification of Tumor Transcripts from Limited Quantity of Esophageal Squamous Cell Carcinoma Tissue Samples, American Journal of Cancer Science; 21, 2015 .

22. Abbas Pishdadian, Abdolreza Varasteh, Mehran Gholamin, Leila Roozbeh Nasiraie,Mitra Hosseinpour, Malihe Moghadam, Mojtaba Sankian, Lung‐derived innate cytokines: new epigenetic targets of allergenspecific sublingual immunotherapy, Iran J Basic Med Sci 2016; 19:64‐71.23. Javad Hami , Razieh Karimi, Hossein Haghir, Mehran Gholamin, Ariane Sadr-Nabavi. Diabetes in Pregnancy

Adversely Affects the Expression of Glycogen Synthase Kinase-3β in the Hippocampus of Rat Neonates, J Mol Neurosci (2015) 57:273–281

24. Ali Bazi, Mohammad Reza Keramati1 and Mehran Gholamin, Role of Oxidative Stress in Modulating Unfolded Protein Response Activity in Chronic Myeloid Leukemia Cell Line, Iranian Biomedical Journal 20(1): 63-67 January 2016

25. Ali Bazi; Mehran Gholamin; Mohsen Sisakht; Mohammad Reza Keramati, Bee Venom Induces Unfolded Protein Response in A172 Glioblastoma Cell Line, Biotech Health Sci. 2015 May; 2(2): e27547

26. Roghayeh Barooei, Reihaneh Alsadat Mahmoudian, Mohammad Reza Abbaszadegan, Atena Mansouri , Mehran Gholamin, Evaluation of thymic stromal lymphopoietin (TSLP) and its correlation with lymphatic metastasis in human gastric cancer; Med Oncol (2015) 32:217

27. Mehran Gholamin, Ali Bazi, Mohammad Reza Abbaszadegan, Idiopathic lymphocytopenia, Curr Opin Hematol 2015, 22:46–52

28. Atena Mansouri, Ali Mohammad Foroughmand, Mohammad Reza Abbaszadegan, Bahram Memar, Reihaneh Alsadat Mahmoudian, Mehran Gholamin, Expression analysis of CD44 isoforms S and V3, in patients with esophageal squamous cell carcinoma, Iran J Basic Med Sci 2015; 18:380-384.

29. Ali Bazi, Mehran Gholamin, Mohamadreza Keramati, Mahdi Esmailzade, Unfolded protein response activity and cell cycle analysis in K562 cell line, Cancer Biology 2014;4(4)

30. Mansouri Atena, Abbaszadegan Mohammad Reza1, Gholamin Mehran, A Review on the Biology of Cancer Stem Cells, Stem Cell Discovery, 2014, 4; 83-89

31. Shirkani A, Abbaszadegan MR, Faridhosseini R, Jabbari Azad F, Mansouri A, Gholamin M, GATA3 Gene Polymorphisms Associated with Allergic Rhinitis in Iranian Population, Reports of Biochemistry and Molecular Biology, 2016 In press

32. Mohammad Mahdi Forghanifard , Mehran Gholamin , Omeed Moaven , Moein Farshchian , Martha Ghahraman •Amir Aledavood ,Mohammad Reza Abbaszadegan, Neoantigen in esophageal squamous cell carcinoma for dendriticcell-based cancer vaccine development, Med Oncol (2014) 31:191

33. Kolsoum Rezaie Kahkhaie , Omeed Moaven , Mohammad Reza Abbaszadegan , Mehdi Montazer , Mehran Gholamin, Specific MUC1 Splice Variants Are Correlated With Tumor Progression in Esophageal CancerWorld J Surg. 2014 Aug;38(8):2052-7

34. Karimi MR, Faridhosseini R, Abbaszadegan MR, Azad FJ, Shirkani A, Riyahi A, Montazar M, Gholamin M. Association of ADAM33 gene polymorphisms with allergic asthma. Iran J Basic Med Sci. 2014 Sep;17(9):716-21.

35. Mohammadi S, Jalali M, Nikravesh MR, Fazel A, Ebrahimzadeh A, Gholamin M, Sankian M, Effects of Vitamin-E treatment on CatSper genes expression and sperm quality in the testis of the aging mouse, Iran J Reprod Med. 2013 Dec;11(12):989-98.

36. Shabnam Mohammadi, Mehdi Jalali1, Mohammad RezaNikravesh1, Mojtaba Sankian, Mehran Gholamin, Alireza Fazel and Alireza Ebrahimzadeh, Combination of vitamin E with L-carnitine increase CatSper Genesexpression in the aging mouse testis; European Journal of Experimental Biology, 2013, 3(4):77-83

37. Shabnam Mohammadi, Mehdi Jalali1, Mohammad Reza Nikravesh, Mehran Gholamin, Alireza Fazel, Alireza Ebrahimzadeh and Mojtaba Sankian, Effects of L-carnitine treatment on expression of CatSper proteins in the aging mouse model, European Journal of Experimental Biology, 2013, 3(3):731-735

38. Simin Mohseni, Mohammad Reza Abbaszadegan, Bahram Memar, Akram Mansourian and Mehran Gholamin, Expression analysis of histidine decarboxylase in esophageal squamous cell carcinoma patientsAnnals of Biological Research, 2013, 4 (6):36-40

39. Mikaelsson E1, Österborg A, Jeddi-Tehrani M, Kokhaei P, Ostadkarampour M, Hadavi R, Gholamin M M, Akhondi M, Shokri F, Rabbani H, Mellstedt H, A proline/arginine-rich end leucine-rich repeat protein (PRELP) variant is uniquely expressed in chronic lymphocytic leukemia cells, PLoS One. 2013 Jun 24;8(6)

40. Mohammad Mahdi Forghanifard, Mehran Gholamin, Moein Farshchian, Omeed Moaven, Bahram Memar,4Mohammad Naser Forghani, Ezzat Dadkhah, Hossein Naseh, Meysam Moghbeli, Reza Raeisossadatiand Mohammad Reza Abbaszadegan, Cancer-testis gene expression profiling in esophageal squamous cell carcinoma, Cancer Biology & Therapy 12:3, 1-8; August 1, 2011

Presentationsفردی

سخنران

پوستر

1Medical Genetic

Congress

Abbaszadegan MR,

Saidi R, Moaven O,

A'rabi, Homaei-

Shandiz F,

Tehran, IranJun 20-2,

2011(Oral

presentation).

Sequential Familial

Esophageal Squamous

Cell Carcinoma and

Breast cancer in several

Pedigrees with BRCA2

Mutations.

√

Gholamin M,

Noferesti GH.

2

Human Genetics

Conference

Forghanifard MM,

Gholamin M,

Abbaszadegan MR.,

(Poster resentation).

Amsterdam

RAI, the

Netherlands

European

2011

May 28 - 31,

2011

In silico and ex vivo

analysis of two chimeric

polytope constructs for

applications in dendritic

cell-based cancer

immuno-genetherapy.

√

3

Post-Genome Methods

of Analysis in Biology

and Laboratory and

Clinical Medicine

Kazan, RussiaNovember

22-24, 2012

Expression of Muc1

Splice Variants as a

tumor marker in

Esophageal Cancer

√

4

5th Yazd International

Congress and student

award in Reproductive

medicine

Yazd19-21 April

2013

Dose α-tochopherol and

L-carnitine increase

CatSper exression in

aging mous

testies?

√

5

13 th Iranian congress

of Biochemistry and 5

th International

Congress of

Biochemistry and

molecular Biology

Yazd16-19 April

2013

Expression analysis of

Histidine decarboxylase

in Esophageal Squamous

cell Caecinoma

√

6

American Academy of

Allergy, Asthma &

Immunology

USA

2014 AAAAI

Annual

Meeting,

February 28-

March 4.

The Association between

Two SNPs GATA3

(rs1269486, rs2229360)

Gene and Allergic

Rhinitis

√

7

The 6th International

Congress of Clinical

Laboratory and Clinic

Iran,Tehran23- 25 Bahman

2014

Application of subtractive

hybridization method to

enrichment of specific

tumor antigens

√

8

The 6th International

Congress of Clinical

Laboratory and Clinic

Iran,Tehran23- 25 Bahman

2014

Expression analysis of

CD44 isoforms S/V3 in

esophageal squamous cell

Carcinoma patients

√

9

12th International

Congress of

Immunology and

Allergy of Iran

Iran,Tehran29 April- 2

May2014

Enrichment and

amplification of tumor-

specific antigens using

advanced molecular

technique

√

10

12th International

Congress of

Immunology and

Allergy of Iran

Iran,Tehran29 April- 2 May2014

Construction of

recombinant transgenic

retrovirus expressing

human DPPA2 gene

√

11

12th International

Congress of

Immunology and

Allergy of Iran

Iran,Tehran29 April- 2 May2014

Expression Analysis of

Isoforms (V3, V6) and

standard form of CD44

Gene in normal

and tumoral tissue in

Esophageal Squamous

Cell Carcinoma

√

12

12th International

Congress of

Immunology and

Allergy of Iran

Iran,Tehran29 April- 2 May2014

Probiotic treatment: a

good strategy for

attenuating of allergic

airway responses, an

experimental model

√

13

15th Annual Research

congressof Iran,s

Medical Sciences

Students

Shahroud,Iran2-5 Sept-

2014

Gene expression

evaluation of innate

cytokine in response to

probiotic treatment in

allergen- sensitized mice,

an experimental model

√

14

1st International

Nastaran Cancer

Symposium-2015

Iran –

Mashhad1 Oct- 2015

Association of two

polymorphism of CD44

gene with clinical

outcome of gastric cancer

patients

15

1st International

Nastaran Cancer

Symposium-2015

Iran -

Mashhad1 Oct- 2015

The correlation analysis

of H. pylori infection on

cellular stress pathway

expression in gastric

cancer

16

1st International

Nastaran Cancer

Symposium-2015

Iran -

Mashhad1 Oct- 2015

Construction of

recombinant transgenic

bacteria expressing

human collagenase3

(MMP13) Gene

17

14th Congress of

Iranian Society of

Medical Oncology and

Hematology

Iran -

Mashhad

14-16 Oct

2015

Matrix metalloproteinase

13 (MMP13); A potential

biomarker for early

detection and survival of

patients with esophageal

squamous cell carcinoma

(ESCC)

18

13th

internationalcongress of

immunology and

allergy of Iran

Iran-Tabriz26-29 April

2016

Isolation and expantion of

CD44+ cancer stem cells

of tumor tissue from

gastric adenocarcinoma

patients

19

13th

internationalcongress of

immunology and

allergy of Iran

Iran-Tabriz26-29 April

2016

Analysis of MMP13 gene

expression in esophageal

squamous cell carcinoma

patients

2013th Iran-Tabriz26-29 April Expression of matrix

internationalcongress of

immunology and

allergy of Iran

2016

metalloproteinase-

13(MMP-13) in human

gastric cancer at the

presence of Helicobacter

Pylori

21

2nd international & 14th

Iranian Genetics

Congress

Iran- Tehran21-23 May

2016

بررسی ارتباط بین بیان و سرطانMMP13ژن

معده در حضورهلیکوباکتر پیلوری

Honors & Awards1394کسب رتبه در جشنواره پژوهشی بعنوان برگزیده پژوهشی گروه ایمونولوژی سال

1394غنی سازی و تکثیر رونوشت های اختصاصی توموری به کمک تکنیک هیبریداسیون کاهشی Members hip Membership

عضو شورای تحصیالت تکمیلی دانشکده پزشکی دانشجویان کارشناسی ارشد و دکترای تخصصی رشته ایمونولوژی–نماینده آموزشی گروه ایمونولوژی

عضو ستاد سلول های بنیادی دانشگاه علوم پزشکی مشهدمدیر گروه علوم آزمایشگاهی- دانشکده علوم پیراپزشکی

Administrative Responsibilities

Other Skills Laboratory Experience:

DNA and RNA Extraction. RT-PCR, PCR-RFLP, PCR-SSCP, ARMS-PCR, Semiquantitative PCR. Cell Culture, Electrophoresis, Real-time PCR, ELISA,WESTERN BLOTT,SDS-PAGE, Clinical lab tests, Electroporation

Computer Skills: Communication and networking, Word processing (Microsoft Word), Adobe Photoshop, Power point, Familiar with genetic software such as Sequencher, Gene Runner, Oligo, KODAK ID Image Analysis Software. Familiar with SPSS statistical software. Flow cytometry analysis soft ware