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Vitamin D3 for Health, Cancer Prevention and Recovery Georgia Tetlow, MD Slide 2 Slide 3 Fellow, University of Arizona Center for Integrative Medicine CEO, Founder of Philadelphia Integrative Medicine Clinical Assistant Professor of Rehabilitation Medicine Thomas Jefferson Medical College Slide 4 Georgia Tetlow, MD Yoga Teacher for 20 years Mindfulness teacher Slide 5 Mission Philadelphia Integrative Medicine offers a comprehensive approach to health and healing which recognizes the whole person, and champions self-care for health, illness recovery and prevention through education, inspiration and empowerment. Slide 6 Mission Philadelphia Integrative Medicine offers a comprehensive approach to health and healing which recognizes the whole person, and champions self-care for health, illness recovery and prevention through education, inspiration and empowerment. Slide 7 Agenda Whats an integrative approach? Diet and Cancer Cancer Vitamin D, Vitamin D and Cancer How much? Working with your doctor Q & A Slide 8 Agenda Whats an integrative approach? Diet, and Diet and Cancer Vitamin D Vitamin D and Cancer How much? Working with your doctor Q & A Slide 9 Integrative Medicine Best of conventional and evidence based alternative Slide 10 Integrative Medicine Treatments that are Safe Effective Compatible with conventional treatment Slide 11 Innate ability to heal Slide 12 Integrative medicine honors the innate ability of the body to heal, values the relationship between patient and physician, and integrates complementary and alternative medicine to support the organism and facilitate healing. --- Victoria Maizes, MD University of Arizona Center for Integrative Medicine Slide 13 Food as medicine Nutrigenomics Slide 14 There is now good evidence that nutrition has significant influences on the expression of genes, and, likewise, genetic variation can have a significant effect on food intake, metabolic response to food, individual nutrient requirements Ferguson LR., Nutrigenomics: integrating genomic approaches into nutrition research., Mol Diagn Ther. 2006;10(2):101-8) Slide 15 Diet and cancer A wealth of evidence points to diet as one of the most important modifiable determinants of the risk of developing cancer Ross, SA., Nutritional Genomic Approaches to Cancer Prevention Research., Exp Oncol. 2007 Dec;29(4):250-6. Slide 16 VITAMIN D3 Sunlight Diet Fatty fish, fish liver oils Fortified foods Milk, yogurt, cereals, orange juice Supplementsfrom fat of lambs wool Hormone Slide 17 VITAMIN D3 Metabolized by liver, kidneys, colon, prostate, breast, lung, pancreas Drug interactions? Steroids like prednisone Some weight loss/cholesterol lowering drugs Phenobarbital and Dilantin (phenytoin) Anti-tuberculosis drugs Statin medications and thiazide diuretics (mild increase) Slide 18 VITAMIN D3 Vitamin D3 as calcitriol indirectly represses and activates oncogenes and tumor suppression genes Vitamin D compounds inhibit cancer growth and even kill cancer cells in vitro and in vivo Slide 19 VITAMIN D3 Anti-proliferative--induce differentiation Slide 20 VITAMIN D3 Anti-proliferative--induce differentiation Slide 21 VITAMIN D3 Normal blood smear Slide 22 VITAMIN D3 Chronic myelogenous leukemia Slide 23 VITAMIN D3 Slide 24 Induction of molecule that restrains cell growth (cancer) vitamin D receptor competes with cancer transcription factor that causes proliferation Inhibits angiogenesis Encourages normal cell cycleincluding cell death Cancer J. 2010;16(1):1-9 Slide 25 VITAMIN D3 Considerable data for role of Vitamin D3 is cancer therapy and prevention No well designed trial of optimal vitamin D has ever been conducted Should be studied as a cancer drug Single agent or in combination Define optimal dose Cancer J. 2010;16(1):1-9 Slide 26 You and Vitamin D How much should I take? What form of vitamin D? Whats my optimal blood level? Slide 27 Dose Institute of Medicine (age 9 and up): minimum 600IU/day Upper limit of normal 4000IU/day Safe level: 2,000IU daily Need blood level to achieve target range Clinicians have different target ranges Slide 28 VITAMIN D3 Blood test: 25-OH vitamin D Slide 29 VITAMIN D3 Slide 30 What kind? Replete all fat soluble vitamins Get A/D3/K1/K2 Vitamin D Complex Slide 31 If there are profits from supplement sales, proceeds go to free educational programs like this one Slide 32 Where www.philly-im.com Proceeds for educational programs!! Code: GT190 10%off Slide 33 Agenda Whats an integrative approach? Diet and Cancer Cancer Vitamin D, Vitamin D and Cancer How much? Working with your doctor Slide 34 Monthly webinarsspread the word! September: Stress Reduction with Dr. Georgia: A Holistic Path for a Modern Lifestyle Friday, 9/28, 12-1pm October: An Integrative Approach to Weight Loss Recording Slide 35 Handouts Best Amount of D3 for a Breast Cancer Survivor Vitamin D Prevents Colorectal Cancer Vitamin D Q&A